Hemolymph exosomes inhibit Spiroplasma eriocheiris infection by promoting Tetraspanin‐mediated hemocyte phagocytosis in crab
Yubo Ma,
No information about this author
Yao Yu,
No information about this author
Xiang Meng
No information about this author
et al.
The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(2)
Published: Jan. 16, 2024
Abstract
Exosomes
released
from
infected
cells
are
thought
to
play
an
important
role
in
the
dissemination
of
pathogens,
as
well
host‐derived
immune
molecules
during
infection.
As
intracellular
pathogen,
Spiroplasma
eriocheiris
is
harmful
multiple
crustaceans.
However,
mechanism
exosomes
infection
has
not
been
investigated.
Here,
we
found
derived
S.
‐infected
crabs
could
facilitate
phagocytosis
and
apoptosis
hemocytes,
resulting
increased
crab
survival
suppression
replication.
Proteomic
analysis
revealed
altered
abundance
Es
Tetraspanin
may
confer
resistance
,
possibly
by
mediating
hemocyte
Eriocheir
sinensis
.
Specifically,
knockdown
E.
susceptibility
displayed
compromised
phagocytic
ability,
whereas
overexpression
Drosophila
S2
inhibited
Further,
it
was
confirmed
that
intramuscular
injection
recombinant
LEL
domain
reduced
mortality
crabs.
Blockade
with
anti‐
serum
exacerbate
invasion
hemocytes
impair
activity.
Taken
together,
our
findings
prove
for
first
time
modulate
resist
pathogenic
invertebrates,
which
proposed
be
mediated
exosomal
Tetraspanin,
supporting
development
preventative
strategies
against
Language: Английский
Infection of Norway lobster ( Nephrops norvegicus ) by the parasite Hematodinium sp.: insights from 30 years of field observations
Royal Society Open Science,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Jan. 1, 2024
The
Norway
lobster,
Nephrops
norvegicus
,
is
an
important
representative
of
the
benthos
and
also
supports
valuable
fisheries
across
Europe.
are
susceptible
to
infection
by
Hematodinium
sp.,
endoparasitic
dinoflagellate
that
causes
morbidity
mortality.
From
epizootiological
perspective,
Clyde
Sea
Area
(CSA;
west
Scotland)
best-studied
–
pathosystem,
with
historical
data
available
between
1988
2008.
We
have
revisited
this
pathosystem
curating
updating
prevalence
values,
differentiating
host
traits
associated
disease
exposure
progression,
comparing
sp.
dynamics
in
CSA
other
locations
decapod
hosts
(
Cancer
pagurus
Carcinus
maenas
).
Prevalence
from
a
2018/2019
survey
(involving
1739
lobsters)
revealed
still
mounts
synchronized
patent
CSA;
hence
pathogen
can
be
considered
as
enzootic
location.
highlight
for
first
time
size
high
severity
infection,
while
females
more
exposed
More
generally,
regardless
(Norway
brown
shore
crabs)
or
geographical
area
(Ireland,
Wales,
Scotland),
infections
peak
spring/summer
reach
their
nadir
during
autumn.
contend
must
one
most
pathogens
crustaceans
temperate
waters.
Language: Английский
Parasitic dinoflagellate Hematodinium in marine decapod crustaceans: a review on current knowledge and future perspectives
Ade Wahyul Fajri Alimin,
No information about this author
Nor Asma Husna Yusoff,
No information about this author
Ince Ayu Khairana Kadriah
No information about this author
et al.
Parasitology Research,
Journal Year:
2023,
Volume and Issue:
123(1)
Published: Dec. 14, 2023
Language: Английский
Haematological deterioration of Hematodinium-infected decapod crustaceans
Developmental & Comparative Immunology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 105307 - 105307
Published: Dec. 1, 2024
Language: Английский
The Immune System and Immune Defence in Crustaceans
Elsevier eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Language: Английский
Extracellular vesicle and citrullination signatures are novel biomarkers in sturgeon (Acipenser gueldenstaedtii) during chronic stress due to seasonal temperature challenge
Fish & Shellfish Immunology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 109974 - 109974
Published: Oct. 1, 2024
Language: Английский