Influenza and COVID-19 co-infection and vaccine effectiveness against severe cases: a mathematical modeling study

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: March 4, 2024

Background Influenza A virus have a distinctive ability to exacerbate SARS-CoV-2 infection proven by in vitro studies. Furthermore, clinical evidence suggests that co-infection with COVID-19 and influenza not only increases mortality but also prolongs the hospitalization of patients. is small-scale recurrent epidemic, increasing likelihood co-epidemic seasonal influenza. The impact on population remains unstudied. Method Here, we developed an age-specific compartmental model simulate co-circulation estimate number co-infected patients under different scenarios prevalent type vaccine coverage. To decrease risk developing severity, investigated minimum coverage required for conjunction vaccine, particularly during seasons. Result Compared single transmission exhibits lower trend delayed peak when Number cases higher than B virus. as becomes more transmissible. As proportion individuals vaccinated vaccines increases, severe illnesses illness decreases time delayed, especially those >60 years old. Conclusion minimize arising from COVID-19, vaccinations are important, priority elderly.

Language: Английский

---

A patient-reported questionnaire for evaluating utilization of the National Essential Public Health Service Program in China among older adults with hypertension and diabetes

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 11, 2025

Objectives This study aimed to develop a patient-reported questionnaire assess service utilization and patient satisfaction among older adults with hypertension diabetes in primary health-care centers operating under China’s National Essential Public Health Service Program (NEPHSP). Methods The questionnaire’s item pool was constructed on the basis of logic model. A cross-sectional survey conducted three provinces mainland China between November December 2019. evaluated using Cronbach’s alpha coefficients confirmatory factor analysis (CFA) refine items internal consistency, construct validity, convergent discriminant validity. Results final adopted second-order model comprising domains: essential services for all adults, follow-up or diabetes, assessment. Through two-step refinement process, nine factors encompassing 29 were selected, including elements such as “health records health education,” “blood pressure/glucose monitoring,” education follow-up.” indicated excellent reliability, values 0.899 0.906. 29-item instrument had robust fit both cohorts. indices included Bollen–Stine bootstrap chi-square degrees freedom ratio (χ 2 /df) 1.78, root mean square error approximation (RMSEA) 0.03, goodness-of-fit index (GFI) 0.97. Similarly, model, χ /df 1.38, RMSEA 0.02, GFI CFA revealed loadings ranging from 0.516 0.940 0.504 0.943 All first-order significantly correlated each other ( p < 0.01), their correlation lower than average variance extracted. models demonstrated strong structural Conclusion valid reliable evaluating center developed China. will serve practical tool assessments within NEPHSP framework at centers.

Language: Английский

---

Heterologous Booster with BNT162b2 Induced High Specific Antibody Levels in CoronaVac Vaccinees

Vaccines, Journal Year: 2023, Volume and Issue: 11(7), P. 1183 - 1183

Published: June 30, 2023

Immune responses after COVID-19 vaccination should be evaluated in different populations around the world. This study compared antibody induced by ChAdOx1 nCoV-19, CoronaVac, and BNT162b2 vaccines. Blood samples from vaccinees were collected pre- post-vaccinations with second third doses. The enrolled 78 vaccinees, of whom 62.8% women, following median ages: 26 years-ChAdOx1 nCoV-19; 40 years-CoronaVac; 30 years-BNT162b2. Serum quantified for anti-RBD IgG IgA anti-spike ELISA. After two vaccine doses, produced higher levels IgG, to nCoV-19 CoronaVac vaccinees. dose booster Individuals who reported a SARS-CoV-2 infection before or during had production. In conclusion, doses studied vaccines detectable heterologous increased Furthermore,

Language: Английский

---

Impact of epidemic prevention policies on public vaccination willingness: empirical research in China

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: July 3, 2024

Background The sudden emergence of the COVID-19 pandemic in early 2020 posed an enormous threat to public health. Vaccination is currently recognized as most cost-effective preventive and control measure against worldwide key constructing a line defense virus, while epidemic prevention policies adopted by governments have important impact on protective behavior public. purpose this study analyze mechanism which stringency affects vaccination willingness explore mediating effect risk perception. Methods A cross-sectional survey was conducted among 387 adults from December 2022 June 2023 China. multiple linear regression model used policy willingness, hierarchical test Results Our results showed that increased approximately 45.5% for every one-unit increase policies, shows has significant positive influence willingness. In addition, perception 38.9% during period stringent government prevention. For perception, 40.9%, relationship between partially mediated Conclusion stricter stronger willingness; plays This finding particularly exploring analyzing factors influencing improving

Language: Английский

---

Differences in COVID-19 Vaccination and Experiences among Patients with Hypertension in Colombia and Jamaica during the COVID-19 Pandemic

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(10), P. 1356 - 1356

Published: Oct. 15, 2024

During the COVID-19 pandemic, hypertensive patients had increased infection and healthcare disruption in many low- middle-income countries (LMICs) with limited vaccine access. The objective of this report is to describe experiences vaccination uptake among Colombia Jamaica. A cross-sectional study hypertension was conducted primary care clinics both between 2021 2022. Trained interviewers used a telephone-administered questionnaire assess (infection, vaccination, access). total 576 (68.5% female, mean age: 67.5 years) participated. Health service affecting access low (<10%). Compared Jamaica, more participants from reported testing positive for COVID-19, having family members or friends positive, losing due being vaccinated. In logistic regression models, adjusted age, sex, education, rural/urban clinic status, fear (OR 2.7, 95% CI: 1.2-6.1) residence 5.9, 2.4-14.6) were associated higher uptake. Disparities diagnosis may have influenced these country differences including Other factors need be better understood prepare future pandemic responses.

Language: Английский

---

COVID-19 Vaccination Services in the Region Kubu Raya District Border

International Journal of Multidisciplinary Approach Research and Science, Journal Year: 2023, Volume and Issue: 1(03), P. 549 - 565

Published: Sept. 30, 2023

The high spread of COVID-19 in Indonesia has impacted various aspects life, both social, cultural, and economic. To tackle the COVID-19, government created a vaccination program to increase immunity against diseases due COVID-19. survey results by Ministry Health Republic show that even though it is free, people who volunteer be vaccinated still need meet expectations. Nationally, only 65%, while West Kalimantan 63%. In Kubu Raya Regency, up August 2021, positive cases reached 3,336 points; 71.82% had received vaccine I got II 47.67%. Service quality one factors can determine success program. This research aims define community expectations regarding services Community Centers border areas Regency. method quantitative, data analysis uses average Cartesian diagrams. service Regency pick-up drop-off model, meaning needs carried out at Center. Still, officers go with elementary requirements. Village Hall. Officer entirely line public expects excellent quality; good category.

Language: Английский

---

Mapping COVID-19 vaccine acceptance and uptake amongst Chinese residents: A systematic review and meta-analysis

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 17, 2023

Abstract Objective Controlling the COVID-19 pandemic depends on widespread acceptance of vaccination. Vaccine hesitancy is a growing area concern in China. The aim study to map overall and uptake rates vaccines across different groups. Methods Five peer-reviewed databases bases were searched (PubMed, EMBASE, Web Science, EBSCO, Scopus). Studies that conducted cross-sectional surveys China understand acceptance/willingness receive included. Results Among 2420 identified studies, 47 studies with 327,046 participants eligible for data extraction. Males had higher (OR=1.17; 95% CI:1.08 - 1.27) along Chinese residents ≥ 5000 RMB monthly income (OR=1.08; CI:1.02 1.14). Conclusion vaccination need be improved. To inform public health decisions, continuous monitoring required.

Language: Английский

---