Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 188, P. 112380 - 112380

Published: Feb. 22, 2024

Intervertebral disc degeneration (IVDD) constitutes a crucial pathological foundation for spinal degenerative diseases (SDD) and stands as primary contributor to both low back pain (LBP) disability. The progression of IVDD is linked structural functional alterations in tissues, where an imbalance the inflammatory microenvironment can induce extracellular matrix (ECM) degradation, senescence, apoptosis. This key pathomechanism disease's development, gaining considerable attention recent years. study aims conduct bibliometric analysis publications pertaining mechanisms quantitatively assess current research hotspots directions.

Language: Английский

The Role of Microvascular Variations in the Process of Intervertebral Disk Degeneration and Its Regulatory Mechanisms: A Literature Review

Orthopaedic Surgery, Journal Year: 2024, Volume and Issue: 16(11), P. 2587 - 2597

Published: Aug. 28, 2024

Microvascular changes are considered key factors in the process of intervertebral disk degeneration (IDD). invasion and growth into nucleus pulposus (NP) cartilaginous endplates unfavorable that trigger IDD. In contrast, rich distribution microvessels bony outer layers annulus fibrosus is an important safeguard for nutrient supply metabolism (IVD). particular, adequate main source nutritional entire IVD. Microvessels can affect progression IDD through a variety pathways. Many studies have explored effects microvessel alterations NP, fibrosus, endplates, on local microenvironment inflammation, apoptosis, senescence. Studies also elucidated roles IDD, as well conducted in‐depth explorations cytokines biologics inhibit or promote ingrowth microvessels. Therefore, present manuscript reviews published literature microvascular IVD to summarize elaborate mechanisms action de novo formation

Language: Английский