Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: April 24, 2025
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 31, 2025
The orderly regulation of immune inflammation and promotion the regeneration skin vessels fibers are key to treatment diabetic injury (DSI). Although various traditional polypeptide biological dressings continue be developed, their efficacy is not satisfactory. In recent years, plant-to-mammal has provided an effective approach for chronic wound management, but development plant-based treatments remains challenging. exosomes from Chinese herbs promising healing. this study, plant derived lemons (Citrus limon) were extracted, was verified. Lemon regulated polarization reprogramming macrophages, promoted proliferation migration vascular endothelial cells fibroblasts, thus healing wounds. To solve problems continuous drug delivery penetration depth, Exosomes loaded into a hydrogel constructed Gelatin Methacryloyl (GelMA) Dialdehyde Starch (DAS) that closely fits skin, absorbs water, swells, moist breathable, effectively promoting sustained slow release resulting in excellent performance Our GelMA-DAS-Lemon (GelMA/DAS/Exo hydrogel) patch represents potentially valuable option repairing wounds clinical applications.
Language: Английский
Citations
2
Viruses, Journal Year: 2025, Volume and Issue: 17(1), P. 74 - 74
Published: Jan. 8, 2025
Flaviviruses are a diverse group of viruses primarily transmitted through hematophagous insects like mosquitoes and ticks. Significant expansion in the geographic range, prevalence, vectors flavivirus over last 50 years has led to dramatic increase infections that can manifest as hemorrhagic fever or encephalitis, leading prolonged morbidity mortality. Millions every year pose serious threat worldwide public health, encouraging scientists develop better understanding pathophysiology immune evasion mechanisms these for vaccine development antiviral therapy. Extensive research been conducted developing effective antivirals flavivirus. Various approaches have extensively utilized clinical trials development, targeting virus entry, replication, polyprotein synthesis processing, egress pathways exploiting well host proteins. However, date, no licensed drug exists treat diseases caused by viruses. Understanding host-pathogen interaction, immunity, viral evasion, disease pathogenesis is highly warranted foster antivirals. This review provides an detailed summary most recent advances drugs combat diseases.
Language: Английский
Citations
1
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 13, 2025
The primary node molecules in the cell signaling network cancer tissues are maladjusted and mutated comparison to normal tissues, which promotes occurrence progression of cancer. Pancreatic (PC) is a highly fatal with increasing incidence low five-year survival rates. Currently, there several therapies that target networks PC. However, PC "cold tumor" unique immunosuppressive tumor microenvironment (poor effector T infiltration, antigen specificity), targeting single gene or pathway basically ineffective clinical practice. Targeted matrix therapy, targeted metabolic mutant vaccines, other emerging have shown great therapeutic potential, but results been disappointing. Therefore, we summarize identified potential drug-resistant aimed at overcoming barriers existing therapies.
Language: Английский
Citations
1
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 31, 2024
The malignant form of melanoma is one the deadliest human cancers that accounts for almost all skin tumor-related fatalities in its later stages. Achieving an exhaustive understanding reliable cancer-specific markers and molecular pathways can provide numerous practical techniques direct way toward development rational curative medicines to increase lifespan patients. Immunotherapy has significantly enhanced treatment metastatic late-stage melanoma, resulting incredible positive responses therapy. Despite increasing occurrence median survival rate patients with advanced, inoperable terminal disease increased from around six months years. current knowledge tumor microenvironment (TME) interaction immune system resulted swift growth innovative immunotherapy treatments. Exosomes are small extracellular vesicles (EVs), ranging 30 150 nm size, majority cells released them. possess natural advantages such as high compatibility living organisms low potential causing reactions, making them delivering therapeutic agents like chemotherapy drugs, nucleic acids, proteins. This review highlights recent advancements using exosomes approach providing medications melanoma.
Language: Английский
Citations
5
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 15, 2025
Cancer vaccines are promising as an effective means of stimulating the immune system to clear tumors well establish surveillance. In this paper, we discuss main platforms and current status cancer propose a new vaccine platform, cytosolic vesicle vaccine. This has unique structure that can integrate antigen adjuvant carriers improve delivery efficiency activation ability, which brings ideas for design. Tumor exosomes carry antigens MHC-peptide complexes, provide tumor antigen-processing cells increase chances recognition by cells. DEVs play role in amplifying response acting dissemination antigenic substances dendritic OMVs, with their natural properties, one advantages preparation antitumor vaccines. paper presents these three bacteria/extracellular vesicles discusses potential applications functionally modified extracellular after cellular engineering or genetic engineering, clinical trials summary, direction research.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2253 - 2253
Published: March 3, 2025
Metabolic dysfunction-associated fatty liver disease (MAFLD) affects approximately one-quarter of the world's adult population, and no effective therapeutic drugs are available. Poria cocos is a fungus used as herb food nutrient for centuries well MAFLD treatment. Exosome-like nanovesicles have many pharmacological activities; however, studies on effects cocos-derived exosome-like (PCELNs) lacking. Therefore, our study aimed at identifying mechanism action PCELNs MAFLD. were isolated by ultracentrifugation their morphology was characterized, such particle size, zeta potential, protein distributions, lipid miRNA compositions. Then, absorption distribution observed in vivo vitro. Finally, L02 cell steatosis model induced fat emulsion mouse high-fat diet (HFD) to evaluate effect membrane structured vesicles, with size 161.4 ± 1.7 nm, potential -3.20 0.37 mV, contained range proteins, lipids, miRNAs. absorbed cells targeted spleen after intraperitoneal injection. inhibited body weight gain improved index heart, liver, spleen, various fats, decreased accumulation level. They also protected mitochondrial ultrastructure regulated oxidative stress energy metabolism disorder. Furthermore, increased PTEN kinase 1 (PINK1), E3 ubiquitin ligase (Parkin) microtubule associated light chain-3 (LC3) expression reduced oxidized DNA (Ox-mtDNA) content mitochondria cytoplasm nucleotide binding oligomerization domain-like receptor 3 (NLRP3), pro-cysteinyl aspartate specific proteinase-1 (caspase-1), cleared-caspase-1, mature-interleukin-1β (IL-1β) levels tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β, interleukin-18 (IL-18) serum liver. In conclusion, we demonstrated that may alleviate HFD-induced promoting autophagy inhibiting NLRP3 inflammasome activation.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 940 - 940
Published: March 10, 2025
Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156694 - 156694
Published: March 1, 2025
Language: Английский
Citations
0
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: April 19, 2025
Language: Английский
Citations
0
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: April 24, 2025
Language: Английский
Citations
0