Metabolism Open,
Journal Year:
2023,
Volume and Issue:
18, P. 100243 - 100243
Published: April 11, 2023
Diabetic
Nephropathy
(DN),
the
most
common
complication
in
diabetes
mellitus,
has
been
affecting
lives
of
people
diabetic
for
a
long
time.
Numerous
studies
have
demonstrated
unbreakable
connection
between
ferroptosis
and
kidney
cell
damage.
Ferroptosis
is
type
iron-dependent,
non-apoptotic,
regulated
death,
characterized
by
buildup
intracellular
lipid
peroxides
to
lethal
levels.
Although
role
programmed
deaths
like
apoptosis,
autophagy,
necroptosis
pathogenesis
DN
demonstrated,
implication
was
least
interrogated.
Hence,
main
aim
this
review
discuss
current
understanding
focusing
on
its
potential
mechanisms,
involvement
DN,
emerging
therapeutic
opportunities.
The American Journal of Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
51(04), P. 997 - 1018
Published: Jan. 1, 2023
Diabetic
nephropathy
(DN)
is
thought
to
be
the
major
cause
of
end-stage
renal
disease.
Due
its
complicated
pathogenesis
and
low
efficacy
DN
treatment,
a
deep
understanding
new
etiological
factors
may
useful.
Ferroptosis,
nonapoptotic
form
cell
death,
characterized
by
accumulation
iron-dependent
lipid
peroxides
lethal
levels.
Ferroptosis-triggered
tubular
injury
reported
participate
in
development
DN,
blocking
ferroptosis
might
an
effective
strategy
prevent
DN.
Quercetin
(QCT),
natural
flavonoid
that
present
variety
fruits
vegetables,
has
been
ameliorate
However,
underlying
nephroprotective
mechanism
unclear.
Herein,
we
explored
antiferroptosic
effect
QCT
verified
using
mice
high
glucose
(HG)-incubated
epithelial
models.
We
found
HG-induced
abnormal
activation
cells,
treatment
inhibited
downregulating
expression
transferrin
receptor
1
(TFR-1)
upregulating
glutathione
peroxidase
4
(GPX4),
ferritin
heavy
chain
(FTH-1),
cystine/glutamate
reverse
antiporter
solute
carrier
family
7
member
(SLC7A11)
HG-incubated
HK-2
cells.
Subsequently,
both
vitro
vivo
results
confirmed
activated
NFE2-related
factor
2
(Nrf2)/Heme
oxygenase-1(HO-1)
signaling
pathway
increasing
levels
Nrf2
HO-1.
Therefore,
this
study
supports
inhibits
cells
regulating
Nrf2/HO-1
pathway,
providing
novel
insight
into
protective
treatment.
Cellular and Molecular Neurobiology,
Journal Year:
2023,
Volume and Issue:
43(7), P. 3329 - 3341
Published: July 17, 2023
Abstract
Ferroptosis
is
a
new
form
of
programmed
cell
death,
which
characterized
by
the
iron-dependent
accumulation
lipid
peroxidation
and
increase
ROS,
resulting
in
oxidative
stress
death.
Iron,
lipid,
multiple
signaling
pathways
precisely
control
occurrence
implementation
ferroptosis.
The
mainly
include
Nrf2/HO-1
pathway,
p62/Keap1/Nrf2
pathway.
Activating
pathway
inhibits
promotes
Furthermore,
some
factors
also
participate
ferroptosis
under
hypoxia,
such
as
HIF-1,
NCOA4,
DMT1.
Meanwhile,
related
with
hypoxia-related
diseases,
MIRI,
cancers,
AKI.
Accordingly,
appears
to
be
therapeutic
target
for
diseases.
International Journal of Biological Sciences,
Journal Year:
2023,
Volume and Issue:
19(9), P. 2678 - 2694
Published: Jan. 1, 2023
Diabetic
kidney
disease
(DKD)
is
one
of
the
most
common
and
severe
microvascular
complications
diabetes
mellitus
(DM),
has
become
leading
cause
end-stage
renal
(ESRD)
worldwide.Although
exact
pathogenic
mechanism
DKD
still
unclear,
programmed
cell
death
been
demonstrated
to
participate
in
occurrence
development
diabetic
injury,
including
ferroptosis.Ferroptosis,
an
iron-dependent
form
driven
by
lipid
peroxidation,
identified
play
a
vital
role
therapeutic
responses
variety
diseases,
such
as
acute
injury
(AKI),
carcinoma
DKD.In
past
two
years,
ferroptosis
well
investigated
patients
animal
models,
but
specific
mechanisms
effects
have
not
fully
revealed.Herein,
we
reviewed
regulatory
ferroptosis,
summarized
recent
findings
associated
with
involvement
DKD,
discussed
potential
promising
target
for
treatment,
thereby
providing
valuable
reference
basic
study
clinical
therapy
DKD.
International Journal of Biological Sciences,
Journal Year:
2023,
Volume and Issue:
19(12), P. 3726 - 3743
Published: Jan. 1, 2023
Ferroptosis
is
an
iron-dependent
programmed
cell
death
pattern
that
characterized
by
iron
overload,
reactive
oxygen
species
(ROS)
accumulation
and
lipid
peroxidation.
Growing
viewpoints
support
the
imbalance
of
homeostasis
disturbance
metabolism
contribute
to
tissue
or
organ
injury
in
various
kidney
diseases
triggering
ferroptosis.
At
present,
key
regulators
complicated
network
mechanisms
associated
with
ferroptosis
have
been
deeply
studied;
however,
its
role
initiation
progression
has
not
fully
revealed.
Herein,
we
aim
discuss
features,
ferroptosis,
explore
emerging
roles
organelles
gather
pharmacological
progress,
systematically
summarize
most
recent
discoveries
about
crosstalk
between
diseases,
including
renal
carcinoma
(RCC),
acute
(AKI),
diabetic
disease
(DKD),
autosomal
dominant
polycystic
(ADPKD),
fibrosis,
lupus
nephritis
(LN)
IgA
nephropathy.
We
further
conclude
potential
therapeutic
strategies
targeting
for
prevention
treatment
hope
this
work
will
provide
insight
study
pathogenesis
kidney-related
diseases.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(25)
Published: June 30, 2023
Abstract
Ferroptosis
plays
an
essential
role
in
the
development
of
diabetes
and
its
complications,
suggesting
potential
therapeutic
strategies
targeting
ferroptosis.
Secretory
autophagosomes
(SAPs)
carrying
cytoplasmic
cargoes
have
been
recognized
as
novel
nano‐warrior
to
defeat
diseases.
Here,
it
is
hypothesized
that
SAPs
derived
from
human
umbilical
vein
endothelial
cells
(HUVECs)
can
restore
function
skin
repair
by
inhibiting
ferroptosis
promote
diabetic
wound
healing.
High
glucose
(HG)‐caused
dermal
fibroblasts
(HDFs)
observed
vitro,
which
results
impaired
cellular
function.
successfully
inhibit
HG‐HDFs,
thereby
improving
their
proliferation
migration.
Further
research
show
inhibitory
effect
on
resulted
a
decrease
endoplasmic
reticulum
(ER)
stress‐regulated
generation
free
ferrous
ions
(Fe
2+
)
HG‐HDFs
increase
exosome
release
discharge
Fe
HG‐HDFs.
Additionally,
proliferation,
migration,
tube
formation
HG‐HUVECs.
Then
are
loaded
into
gelatin‐methacryloyl
(GelMA)
hydrogels
fabricate
functional
dressings.
The
demonstrate
Gel‐SAPs
wounds
restoring
normal
behavior
cells.
These
findings
suggest
promising
SAP‐based
strategy
for
treatment
ferroptosis‐associated
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 4, 2023
Diabetic
nephropathy
(DN)
is
a
chronic
inflammatory
disease
that
affects
millions
of
diabetic
patients
worldwide.
The
key
to
treating
DN
early
diagnosis
and
prevention.
Once
the
patient
enters
clinical
proteinuria
stage,
renal
damage
difficult
reverse.
Therefore,
developing
treatment
methods
critical.
pathogenesis
results
from
various
factors,
among
which
immune
response
inflammation
play
major
roles.
Ferroptosis
newly
discovered
type
programmed
cell
death
characterized
by
iron-dependent
lipid
peroxidation
excessive
ROS
production.
Recent
studies
have
demonstrated
activation
closely
related
occurrence
development
ferroptosis.
Moreover,
hyperglycemia
induces
iron
overload,
peroxidation,
oxidative
stress,
inflammation,
fibrosis,
all
are
pathogenesis,
indicating
ferroptosis
plays
role
in
DN.
this
review
focuses
on
regulatory
mechanisms
ferroptosis,
mutual
processes
involved
inflammation.
By
discussing
analyzing
relationship
between
DN,
we
can
deepen
our
understanding
develop
new
therapeutics
targeting
or
inflammation-related
for
with
Renal Failure,
Journal Year:
2024,
Volume and Issue:
46(1)
Published: March 11, 2024
Diabetic
kidney
disease
(DKD)
is
a
leading
factor
in
end-stage
renal
disease.
The
complexity
of
its
pathogenesis,
combined
with
the
limited
treatment
efficacy,
necessitates
deeper
insights
into
potential
causes.
Studies
suggest
that
ferroptosis-driven
tubular
damage
contributes
to
DKD's
progression,
making
counteraction
therapeutic
strategy.
Quercetin,
flavonoid
found
numerous
fruits
and
vegetables,
has
demonstrated
DKD
mitigation
mouse
models,
though
protective
mechanism
remains
ambiguous.
In
this
study,
we
delved
quercetin's
anti-ferroptotic
properties,
employing
rat
model
high
glucose
(HG)-treated
epithelial
cell
models.
Our
findings
revealed
HG
prompted
unusual
ferroptosis
activation
cells.
However,
quercetin
counteracted
by
inhibiting
activating
NFE2-related
2
(Nrf2)
expression
both
rats
HG-treated
HK-2
cells,
indicating
role.
Further
experiments,
vivo
vitro,
validated
stimulates
Nrf2.
Thus,
our
research
underscores
modulating
process
via
Nrf2
distinct
model,
offering
fresh
perspective
on
mechanisms.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 12, 2024
Abstract
Chronic
kidney
disease
(CKD)
has
historically
been
a
significant
global
health
concern,
profoundly
impacting
both
life
and
well-being.
In
the
process
of
CKD,
with
gradual
loss
renal
function,
incidence
various
life-threatening
complications,
such
as
cardiovascular
diseases,
cerebrovascular
accident,
infection
stroke,
is
also
increasing
rapidly.
Unfortunately,
existing
treatments
exhibit
limited
ability
to
halt
progression
injury
in
emphasizing
urgent
need
delve
into
precise
molecular
mechanisms
governing
occurrence
development
CKD
while
identifying
novel
therapeutic
targets.
Renal
fibrosis,
typical
pathological
feature
plays
pivotal
role
disrupting
normal
structures
function.
Ferroptosis
recently
discovered
iron-dependent
form
cell
death
characterized
by
lipid
peroxide
accumulation.
emerged
potential
key
player
diseases
initiation
organ
fibrosis.
Substantial
evidence
suggests
that
ferroptosis
may
significantly
contribute
intricate
interplay
between
its
progression.
This
review
comprehensively
outlines
relationship
terms
iron
metabolism
peroxidation,
discusses
current
landscape
pharmacological
research
on
ferroptosis,
shedding
light
promising
avenues
for
intervention.
It
further
illustrates
recent
breakthroughs
ferroptosis-related
regulatory
implicated
thereby
providing
new
insights
treatment.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 3, 2024
Ferroptosis
is
a
form
of
non-apoptotic
regulated
cell
death
(RCD)
that
depends
on
iron
and
characterized
by
the
accumulation
lipid
peroxides
to
lethal
levels.
involves
multiple
pathways
including
redox
balance,
regulation,
mitochondrial
function,
amino
acid,
lipid,
glycometabolism.
Furthermore,
various
disease-related
signaling
also
play
role
in
regulating
process
oxidation.
In
recent
years,
with
emergence
concept
ferroptosis
in-depth
study
its
mechanisms,
closely
associated
biological
conditions
related
kidney
diseases,
organ
development,
aging,
immunity,
cancer.
This
article
reviews
development
ferroptosis,
mechanisms
(including
GSH-GPX4,
FSP1-CoQ1,
DHODH-CoQ10,
GCH1-BH4,
MBOAT1/2
pathways),
latest
research
progress
involvement
diseases.
It
summarizes
diseases
within
frameworks
metabolism,
reactive
oxygen
biology,
biology.
The
introduces
key
regulatory
factors
as
well
important
concepts
major
open
questions
natural
compounds.
hoped
future
research,
further
breakthroughs
can
be
made
understanding
regulation
mechanism
utilizing
promote
treatments
for
such
acute
injury(AKI),
chronic
disease
(CKD),
diabetic
nephropathy(DN),
renal
carcinoma.
paves
way
new
approach
prevent,
treat
clinical
