Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 13, 2025
Ferroptosis,
a
recently
discovered
iron-dependent
cell
death,
is
linked
to
various
diseases
but
its
role
in
endometriosis
still
not
fully
understood.
In
this
study,
we
integrated
microarray
data
of
from
the
GEO
database
and
ferroptosis-related
genes
(FRGs)
FerrDb
further
investigate
regulation
ferroptosis
impact
on
immune
microenvironment.
WGCNA
identified
modules,
annotated
by
GO
&
KEGG.
MNC
algorithm
pinpointed
hub
FRGs.
Cytoscape
construct
ceRNA
network,
ROC
curves
evaluated
diagnostic
efficacy
Consensus
cluster
analysis
subclusters,
CIBERSORT
assessed
infiltration
these
subclusters.
Finally,
RT-qPCR
validated
FRG
expression
clinical
tissues.
We
two
modules
endometriosis,
enrichment
analysis,
they
are
closely
with
autophagy,
mTOR,
oxidative
stress,
FOXO
pathways.
Furthermore,
10
FRGs,
curve
showed
better
predictive
ability
for
diagnosing.
confirmed
that
tissue
FRGs
was
mostly
consistent
results.
Subsequently,
developed
network
based
4
(BECN1,
OSBPL9,
TGFBR1,
GSK3B).
Next,
subclusters
stage.
Importantly,
illustrated
levels
cells
checkpoint
were
significantly
different
Specifically,
subcluster
stage
III-IV
more
inclined
immunosuppressive
Our
study
may
jointly
promote
progression
remodeling
microenvironment,
offering
new
insights
into
pathogenesis
therapeutics.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 6, 2023
Regulation
of
cell
mortality
for
disease
treatment
has
been
the
focus
research.
Ferroptosis
is
an
iron-dependent
regulated
death
whose
mechanism
extensively
studied
since
its
discovery.
A
large
number
studies
have
shown
that
regulation
ferroptosis
brings
new
strategies
various
benign
and
malignant
diseases.
Iron
excess
lipid
peroxidation
are
primary
metabolic
features.
Therefore,
genes
involved
in
iron
metabolism
can
regulate
overload
through
direct
or
indirect
pathways,
thereby
regulating
ferroptosis.
In
addition,
glutathione
(GSH)
body’s
non-enzymatic
antioxidants
plays
a
pivotal
role
struggle
against
peroxidation.
GSH
functions
as
auxiliary
substance
peroxidase
4
(GPX4)
to
convert
toxic
peroxides
their
corresponding
alcohols.
Here,
we
reviewed
researches
on
recent
years,
comprehensively
analyzed
regulatory
process
from
metabolism,
then
described
detail
GPX4
main
antioxidant
vivo
.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(5), P. 820 - 820
Published: May 11, 2023
Cell
death
includes
programmed
and
nonprogrammed
cell
death.
The
former
mainly
ferroptosis,
necroptosis,
pyroptosis,
autophagy,
apoptosis,
while
the
latter
refers
to
necrosis.
Accumulating
evidence
shows
that
pyroptosis
play
essential
regulatory
roles
in
development
of
intestinal
diseases.
In
recent
years,
incidence
inflammatory
bowel
disease
(IBD),
colorectal
cancer
(CRC),
injury
induced
by
ischemia-reperfusion
(I/R),
sepsis,
radiation
have
gradually
increased,
posing
a
significant
threat
human
health.
advancement
targeted
therapies
for
diseases
based
on
provides
new
strategies
treating
Herein,
we
review
with
respect
regulation
highlight
underlying
molecular
mechanisms
potential
therapeutic
applications.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 4, 2022
Malignant
tumor
is
a
major
killer
that
seriously
endangers
human
health.
At
present,
the
methods
of
treating
tumors
include
surgical
resection,
chemotherapy,
radiotherapy
and
immunotherapy.
However,
survival
rate
patients
still
very
low
due
to
complicated
mechanism
occurrence
development
high
recurrence
rate.
Individualized
treatment
will
be
main
direction
in
future.
Because
only
by
understanding
molecular
differentially
expressed
genes
can
we
carry
out
accurate
improve
therapeutic
effect.
MicroRNA
(miRNA)
kind
small
non
coding
RNA,
which
regulates
gene
expression
at
mRNA
level
plays
key
role
regulation.
Ferroptosis
programmed
death
caused
iron
dependent
lipid
peroxidation,
different
from
apoptosis,
necrosis
other
cell
modes.
Now
it
has
been
found
ferroptosis
an
important
drug
resistance.
More
more
studies
have
miRNAs
regulate
resistance
through
ferroptosis.
Therefore,
this
review,
briefly
outlined,
relationship
between
reviewed.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 29, 2023
Abstract
Programmed
cell
death
(PCD)
plays
an
important
role
in
many
aspects
of
individual
development,
maintenance
body
homeostasis
and
pathological
processes.
Ferroptosis
is
a
novel
form
PCD
characterized
by
the
accumulation
iron-dependent
lipid
peroxides
resulting
lethal
damage.
It
contributes
to
tumor
progression
apoptosis-independent
manner.
In
recent
years,
increasing
number
non-coding
RNAs
(ncRNAs)
have
been
demonstrated
mediate
biological
process
ferroptosis,
hence
impacting
carcinogenesis,
progression,
drug
resistance,
prognosis.
However,
clear
regulatory
mechanism
for
this
phenomenon
remains
poorly
understood.
Moreover,
ferroptosis
does
not
usually
exist
independently.
Its
interaction
with
PCD,
like
apoptosis,
necroptosis,
autophagy,
pyroptosis,
cuproptosis,
destroy
cells
appears
exist.
Furthermore,
ncRNA
seems
be
involved.
Here,
we
review
mechanisms
which
occurs,
dissect
its
relationship
other
forms
death,
summarize
key
roles
played
ncRNAs,
raise
relevant
questions
predict
possible
barriers
application
clinic,
offering
new
ideas
targeted
tumour
therapy.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(17), P. 13336 - 13336
Published: Aug. 28, 2023
As
a
novel
form
of
regulated
cell
death,
ferroptosis
is
characterized
by
intracellular
iron
and
lipid
peroxide
accumulation,
which
different
from
other
death
forms
morphologically,
biochemically,
immunologically.
Ferroptosis
metabolism,
antioxidant
defense
systems
as
well
various
transcription
factors
related
signal
pathways.
Emerging
evidence
has
highlighted
that
associated
with
many
physiological
pathological
processes,
including
cancer,
neurodegeneration
diseases,
cardiovascular
ischemia/reperfusion
injury.
Noncoding
RNAs
are
group
functional
RNA
molecules
not
translated
into
proteins,
can
regulate
gene
expression
in
manners.
An
increasing
number
studies
have
shown
noncoding
RNAs,
especially
miRNAs,
lncRNAs,
circRNAs,
interfere
the
progression
modulating
ferroptosis-related
genes
or
proteins
directly
indirectly.
In
this
review,
we
summarize
basic
mechanisms
regulations
focus
on
recent
mechanism
for
types
ncRNAs
to
conditions,
will
deepen
our
understanding
regulation
provide
new
insights
employing
ferroptosis-associated
therapeutic
strategies.
Epigenetics & Chromatin,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 15, 2025
Colorectal
cancer
(CRC)
remains
one
of
the
most
common
causes
cancer-related
mortality
worldwide.
Its
progression
is
influenced
by
complex
interactions
involving
genetic,
epigenetic,
and
environmental
factors.
Non-coding
RNAs
(ncRNAs),
including
microRNAs
(miRNAs),
long
non-coding
(lncRNAs),
circular
(circRNAs),
have
been
identified
as
key
regulators
gene
expression,
affecting
diverse
biological
processes,
notably
programmed
cell
death
(PCD).
This
review
aims
to
explore
relationship
between
ncRNAs
PCD
in
CRC,
focusing
on
how
influence
survival,
proliferation,
treatment
resistance.
A
comprehensive
literature
analysis
was
conducted
examine
recent
findings
role
modulating
various
mechanisms,
apoptosis,
autophagy,
necroptosis,
pyroptosis,
their
impact
CRC
development
therapeutic
response.
were
found
significantly
regulate
pathways,
impacting
tumor
growth,
metastasis,
sensitivity
CRC.
Their
these
pathways
highlights
potential
biomarkers
for
early
detection
targets
innovative
interventions.
Understanding
involvement
regulation
offers
new
insights
into
biology.
The
targeted
modulation
ncRNA-PCD
presents
promising
avenues
personalized
treatment,
which
may
improve
patient
outcomes
enhancing
effectiveness
reducing
