KIAA1429
is
a
major
m6A
methyltransferase,
which
plays
important
biological
and
pharmacological
roles
in
both
human
cancer
or
non-cancer
diseases.KIAA1429
produce
tumorigenic
role
various
cancers
through
regulating
DAPK3,
ID2,
GATA3,
SMC1A,
CDK1,
SIRT1
other
targets,
promoting
cell
proliferation,
migration,
invasion,
metastasis
tumor
growth
.At
the
same
time,
also
effective
non-tumor
diseases,
such
as
reproductive
system
cardiovascular
diseases.The
potential
regulatory
mechanism
of
dependent
on
modification
related
to
mRNA,
lncRNA,
circRNA
miRNAs.In
this
review,
we
summarized
current
evidence
diseases
its
prognostic
target.
PeerJ,
Journal Year:
2022,
Volume and Issue:
10, P. e14334 - e14334
Published: Nov. 10, 2022
KIAA1429
is
a
major
m6A
methyltransferase,
which
plays
important
biological
and
pharmacological
roles
in
both
human
cancer
or
non-cancer
diseases.
produce
tumorigenic
role
various
cancers
through
regulating
DAPK3,
ID2,
GATA3,
SMC1A,
CDK1,
SIRT1
other
targets,
promoting
cell
proliferation,
migration,
invasion,
metastasis
tumor
growth
.
At
the
same
time,
also
effective
non-tumor
diseases,
such
as
reproductive
system
cardiovascular
The
potential
regulatory
mechanism
of
dependent
on
modification
related
to
mRNA,
lncRNA,
circRNA
miRNAs.
In
this
review,
we
summarized
current
evidence
diseases
its
prognostic
target.
Cancer Cell International,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: June 26, 2023
Abstract
N
6
-methyladenosine
(m
A),
one
of
the
most
common
RNA
methylation
modifications,
has
emerged
in
recent
years
as
a
new
layer
regulatory
mechanism
controlling
gene
expression
eukaryotes.
As
reversible
epigenetic
modification,
m
A
not
only
occurs
on
mRNAs
but
also
Long
non-coding
RNAs
(LncRNAs).
we
all
known,
despite
LncRNAs
cannot
encode
proteins,
they
affect
proteins
by
interacting
with
or
miRNAs,
thus
playing
important
roles
occurrence
and
development
variety
tumors.
Up
to
now,
it
been
widely
accepted
that
modification
affects
fate
corresponding
LncRNAs.
Interestingly,
levels
functions
modifications
are
mediated
through
affecting
methyltransferases
(METTL3,
METTL14,
WTAP,
METTL16,
etc.),
demethylases
(FTO,
ALKBH5)
methyl-binding
(YTHDFs,
YTHDCs,
IGF2BPs,
HNRNPs,
which
collectively
referred
“m
regulators”.
In
this
review,
summarized
mutual
regulation
mechanisms
between
cancer
progression,
metastasis,
invasion
drug
resistance.
detail,
focus
specific
is
demethylases,
involves
LncRNA
first
part.
And
section
two
intensively
displays
mediation
via
changing
proteins.
At
last
part,
described
interaction
effects
during
various
tumor
development.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: Aug. 1, 2024
Breast
cancer
is
the
most
common
in
women
and
leading
cause
of
female
deaths
by
world
worldwide.
Hence,
understanding
molecular
mechanisms
associated
with
breast
development
progression,
including
drug
resistance
metastasis,
essential
for
achieving
best
management
patients.
Cancer-related
long
noncoding
RNAs
have
been
shown
to
be
involved
regulation
each
stage
progression.
Additionally,
exosomes
are
extracellular
microvesicles
that
central
intercellular
communication
play
an
important
role
tumorigenesis.
Exosomes
can
released
from
primary
tumor
cells
into
bloodstream
transmit
cellular
signals
distant
body
sites.
In
this
work,
we
review
findings
regarding
regulated
exosomal
lncRNAs
essentials
chemoresistance
metastasis
cancer.
Likewise,
evaluate
outcomes
potential
clinical
use
as
biomarkers
achieve
personalized
This
finding
highlights
importance
transcriptomic
analysis
understand
tumorigenesis
well
improve
tests
available
disease.
International Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
154(11), P. 1877 - 1889
Published: March 1, 2024
Abstract
In
recent
years,
breast
cancer
(BC)
has
surpassed
lung
as
the
most
common
malignant
tumor
worldwide
and
remains
leading
cause
of
death
in
women.
The
etiology
BC
usually
involves
dysregulation
epigenetic
mechanisms
aberrant
expression
certain
non‐coding
RNAs
(ncRNAs).
N6‐methyladenosine
(m6A),
prevalent
RNA
modification
eukaryotes,
widely
exists
ncRNAs
to
affect
its
biosynthesis
function,
is
an
important
regulator
tumor‐related
signaling
pathways.
Interestingly,
can
also
regulate
or
target
m6A
modification,
playing
a
key
role
progression.
However,
m6A‐ncRNAs
regulatory
network
not
been
fully
elucidated,
especially
regulation
by
ncRNAs.
Therefore,
this
review,
we
comprehensively
summarize
interaction
biological
significance
modifications
BC.
Meanwhile,
focused
on
clinical
application
value
diagnosis
prognosis,
intending
explore
new
biomarkers
potential
therapeutic
targets.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(3)
Published: April 1, 2024
Abstract
Breast
cancer
(BC)
poses
a
persistent
global
health
challenge,
particularly
in
countries
with
elevated
human
development
indices
linked
to
factors
such
as
increased
life
expectancy,
education,
and
wealth.
Despite
therapeutic
progress,
challenges
persist,
the
role
of
epitranscriptomic
RNA
modifications
BC
remains
inadequately
understood.
The
epitranscriptome,
comprising
diverse
posttranscriptional
on
molecules,
holds
potential
intricately
modulate
function
regulation,
implicating
dysregulation
various
diseases,
including
BC.
Noncoding
RNAs
(ncRNAs),
acting
regulators,
influence
physiological
pathological
processes,
cancer.
long
noncoding
(lncRNAs)
microRNAs
(miRNAs)
add
an
extra
layer
gene
expression
control.
This
review
delves
into
recent
insights
modifications,
N‐6‐methyladenosine
(m6A),
adenine‐to‐inosine
(A‐to‐I)
editing,
5‐methylcytosine
(m5C),
specifically
context
lncRNA
miRNAs
BC,
highlighting
their
implications
progression.
Understanding
this
intricate
regulatory
landscape
is
vital
for
deciphering
molecular
mechanisms
underlying
identifying
targets.
International Journal of General Medicine,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1047 - 1073
Published: Feb. 1, 2025
Atherosclerosis,
a
progressive
inflammatory
disease
of
the
arteries,
remains
leading
cause
cardiovascular
morbidity
and
mortality
worldwide.
Recent
years
have
witnessed
pivotal
role
N6-methyladenosine
(m6A)
RNA
methylation
in
regulating
various
biological
processes,
including
those
implicated
atherosclerosis.
Current
evidence
suggested
that
m6A
regulators
(writers,
erasers,
readers)
participated
modification
multiple
non-coding
RNAs
(ncRNAs),
microRNAs
(miRNAs),
long
(lncRNAs),
circular
(circRNAs),
thereby
affecting
their
metabolism
functions.
Meanwhile,
ncRNAs
also
emerged
as
key
modulator
expression
turn.
Therefore,
understanding
mutual
regulation
between
modifications
is
great
significance
to
identify
novel
therapeutic
targets
for
atherosclerosis
has
clinical
application
prospects.
This
review
aims
summarize
recent
advances
reciprocal
provide
insights
into
interaction
context
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: Oct. 12, 2023
Up
till
the
present
moment,
breast
cancer
is
still
leading
cause
of
cancer-related
death
in
women
worldwide.
Although
treatment
methods
and
protocols
for
are
constantly
improving,
long-term
prognosis
patients
not
optimistic
due
to
complex
heterogeneity
disease,
multi-organ
metastasis,
chemotherapy
radiotherapy
resistance.
As
a
newly
discovered
class
non-coding
RNAs,
ncRNAs
play
an
important
role
various
cancers.
Especially
cancer,
lncRNAs
have
received
extensive
attention
been
confirmed
regulate
progression
through
variety
pathways.
Meanwhile,
study
epigenetic
modification,
including
DNA
methylation,
RNA
methylation
histone
has
developed
rapidly
recent
years,
which
greatly
promoted
RNAs
cancer.
In
this
review,
we
carefully
comprehensively
describe
interactions
between
several
major
classes
modifications
ncRNAs,
as
well
their
different
subsequent
biological
effects,
discuss
potential
practical
clinical
applications.
Breast Cancer Research,
Journal Year:
2024,
Volume and Issue:
26(1)
Published: July 3, 2024
Abstract
Breast
cancer
(BC)
is
a
highly
prevalent
malignancy
worldwide,
with
complex
pathogenesis
and
treatment
challenges.
Research
reveals
that
methyltransferase-like
3
(METTL3)
widely
involved
in
the
of
several
tumors
through
methylation
its
target
RNAs,
role
mechanisms
BC
are
also
extensively
studied.
In
this
review,
we
aim
to
provide
comprehensive
interpretation
available
studies
elucidate
relationship
between
METTL3
BC.
This
review
suggests
high
levels
associated
pathogenesis,
poor
prognosis,
drug
resistance
BC,
suggesting
as
potential
diagnostic
or
prognostic
biomarker
therapeutic
target.
Collectively,
provides
understanding
how
functions
RNA
methylation,
which
valuable
reference
for
future
fundamental
clinical
applications.
