A Novel Tri-Coordination Zinc Complex Functionalized Silicotungstate with ROS Catalytic Ability and Anti-Tumor Cells Activity DOI Open Access
Xiang Ma, Jiai Hua, Man Wang

et al.

Catalysts, Journal Year: 2022, Volume and Issue: 12(7), P. 695 - 695

Published: June 24, 2022

Reactive oxygen species (ROS) can be used as an effective method to treat tumors. Artificial oxidase has received increasing attention a catalyst for ROS generation in fields ranging from bioinorganic chemistry pharmaceutical chemistry. In this study, artificial based on binuclear zinc complex and Keggin-type silicotungstate [Zn2(4,4′-bpy)(Phen)2][SiW12O40] (ZSW) (4,4′-bpy = 4,4′-bipyridine; Phen 1,10-phenanthroline) was synthesized structurally featured terms of its X-ray photoelectron spectrum (XPS), bond valence sum (Σs) calculation, IR spectra, single-crystal diffraction (SXRD). ZSW is ionic compound which the cation [Zn2(4,4′-bpy)(Phen)2]4+ anion α-Keggin-type [SiW12O40]4– cluster. Notably, Zn ions [Zn2(4,4′-bpy)(Phen)2] exist tri-coordination, first obtained polyoxometalate (POM) It also demonstrated that capable efficiently catalyzing production ROS, which, according computational calculations, may due synergistic action complexes POM building blocks. Furthermore, exhibited inhibition ability toward ROS-sensitive tumor cells, such PC12 cells.

Language: Английский

A Nanoenzyme Constructed from Manganese and Strandberg-Type Phosphomolybdate with Versatility in Antioxidant and Modulating Conformation of Aβ Protein Misfolding Aggregates In Vitro DOI Open Access
Jiai Hua, Feng Wang,

Xueman Wei

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4317 - 4317

Published: Feb. 21, 2023

Amyloid β-peptide (Aβ) misfolding aggregates with β-sheet structures and surplus reactive oxygen species (ROS) are both considered to be the culprit of neuronal toxicity in Alzheimer's disease (AD). Therefore, modulating mode Aβ inhibiting ROS simultaneous has become an important method for anti-AD. Herein, a nanoscale manganese-substituted polyphosphomolybdate (H2en)3[Mn(H2O)4][Mn(H2O)3]2[P2Mo5O23]2·14.5H2O (abbreviated as MnPM) (en = ethanediamine) was designed synthesized by single crystal transformation method. MnPM can modulate rich conformation aggregates, thus reduce formation toxic species. Moreover, also possesses ability eliminate free radicals produced Cu2+-Aβ aggregates. It inhibit cytotoxicity β-sheet-rich protect synapses PC12 cells. combines anti-oxidation ability, which makes promising multi-funcational molecular composite mechanism new conceptual designing treatment such protein-misfolding diseases.

Language: Английский

Citations

6
A Cyclen-Functionalized Cobalt-Substituted Sandwich-Type Tungstoarsenate with Versatility in Removal of Methylene Blue and Anti-ROS-Sensitive Tumor Cells DOI Creative Commons
Jiai Hua,

Xueman Wei,

Yifeng Li

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(19), P. 6451 - 6451

Published: Sept. 30, 2022

Oxidative degradation by using reactive oxygen species (ROS) is an effective method to treat pollutants. The synthesis of artificial oxidase for the dyes a hot spot in molecular science. In this study, nanoscale sandwich-type polyoxometalate (POM) on basis tetra-nuclear cobalt cluster and trivacant B-α-Keggin-type tungstoarsenate {[Co(C8H20N4)]4}{Co4(H2O)2[HAsW9O34]2}∙4H2O (abbreviated as CAW, C8H20N4 = cyclen) has been synthesized structurally examined infrared (IR) spectrum, ultraviolet-visible (UV-Vis) X-ray photoelectron spectrum (XPS), single-crystal diffraction (SXRD), bond valence sum (Σs) calculation. According structural analysis, principal element CAW derived from modifying polyanion {Co4(H2O)2 [HAsW9O34]2}8- with four [Co(Cyclen)]2+, which 1,4,7,10-tetraazacyclododecane (cyclen) firstly applied modify POM. It also demonstrated that capable efficiently catalyzing production ROS synergistic effects POM fragments Co-cyclen complexes. Moreover, can interfere morphology proliferation sensitive cells producing exhibits ability specifically eliminating methylene blue (MB) solution system both adsorption catalytic oxidation.

Language: Английский

Citations

7
A Heterogeneous Catalyzed Oxidase Consists of Zinc-Substituted Arsenomolybdate with Reactive Oxygen Species Catalytic Ability DOI
Xiang Ma, Jiai Hua,

Chengzhi Xu

et al.

Journal of Cluster Science, Journal Year: 2021, Volume and Issue: 33(6), P. 2625 - 2633

Published: Oct. 5, 2021

Language: Английский

Citations

7
A Novel Tri-Coordination Zinc Complex Functionalized Silicotungstate with ROS Catalytic Ability and Anti-Tumor Cells Activity DOI Open Access
Xiang Ma, Jiai Hua, Man Wang

et al.

Catalysts, Journal Year: 2022, Volume and Issue: 12(7), P. 695 - 695

Published: June 24, 2022

Reactive oxygen species (ROS) can be used as an effective method to treat tumors. Artificial oxidase has received increasing attention a catalyst for ROS generation in fields ranging from bioinorganic chemistry pharmaceutical chemistry. In this study, artificial based on binuclear zinc complex and Keggin-type silicotungstate [Zn2(4,4′-bpy)(Phen)2][SiW12O40] (ZSW) (4,4′-bpy = 4,4′-bipyridine; Phen 1,10-phenanthroline) was synthesized structurally featured terms of its X-ray photoelectron spectrum (XPS), bond valence sum (Σs) calculation, IR spectra, single-crystal diffraction (SXRD). ZSW is ionic compound which the cation [Zn2(4,4′-bpy)(Phen)2]4+ anion α-Keggin-type [SiW12O40]4– cluster. Notably, Zn ions [Zn2(4,4′-bpy)(Phen)2] exist tri-coordination, first obtained polyoxometalate (POM) It also demonstrated that capable efficiently catalyzing production ROS, which, according computational calculations, may due synergistic action complexes POM building blocks. Furthermore, exhibited inhibition ability toward ROS-sensitive tumor cells, such PC12 cells.

Language: Английский

Citations

5