Impact of Metal Ions on Cellular Functions: A Focus on Mesenchymal Stem/Stromal Cell Differentiation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10127 - 10127

Published: Sept. 20, 2024

Metals play a crucial role in the human body, especially as ions metalloproteins. Essential metals, such calcium, iron, and zinc are for various physiological functions, but their interactions within biological networks complex not fully understood. Mesenchymal stem/stromal cells (MSCs) essential tissue regeneration due to ability differentiate into cell types. This review article addresses effects of unphysiological, directly toxic, metal ion concentrations, particularly concerning MSCs. Overloading or unbalancing concentrations can significantly impair function differentiation capacity In addition, excessive unbalanced lead oxidative stress, which affect viability inflammation. Data on MSC limited often contradictory. Future research should, therefore, aim clarify mechanisms by differentiation, focusing aspects interactions, exposure duration, other environmental conditions. Understanding these could ultimately improve design biomaterials implants promote MSC-mediated regeneration. It also development innovative therapeutic strategies regenerative medicine.

Language: Английский

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Potentials of microbe-plant assisted bioremediation in reclaiming heavy metal polluted soil environments for sustainable agriculture

Environmental and Sustainability Indicators, Journal Year: 2024, Volume and Issue: 22, P. 100396 - 100396

Published: April 23, 2024

Crop intensification has increased as human population growth drives the demand for food. However, urbanization, industrialization, and contamination of soil by heavy metal (HM) have become significant challenges to agricultural production. Urbanization activities jeopardize harm health, which is critical environment, ecosystems, sustainable agriculture, global economy. Smelting, mining, other industrial that release toxic HMs into environment significantly reduce with serious consequences both plants humans. Furthermore, achievement agriculture severely inhibited presence HM in soil. Hence, combat subsequent reduction crop output brought on contamination, it necessary engage suitable microbes remove these pollutants. This will result a more productive safety foods, realization food security. Therefore, this study explored efficacy, advantages, limitations current conventional methods remediation well potential like Pseudomonas aeruginosa, Vibrio parahaemolyticus, Alyxia rubricaulis, Maytenus bureaviana reclamation polluted agriculture. Employing natural non-hazardous contaminants, highlighted review, would help improve health quality, increase production, promote outlined United Nations' Sustainable Development Goals.

Language: Английский

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Intensification of Cr(VI) adsorption using activated carbon adsorbent modified with ammonium persulfate

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 23, 2024

Abstract Granular activated carbon has been modified by ammonium persulfate as a new adsorbent for Cr(VI) adsorption from aqueous solutions. The was characterized nitrogen adsorption–desorption isotherm data and infrared spectroscopy. impact of different factors, such the initial pH level solution, time, temperature, ionic strength, concentration ion, on efficiencies studied batch experiments. Kinetic studies thermodynamics with persulfate-modified were carefully studied. results showed that follows pseudo-second-order kinetic model reaction is endothermic spontaneous. scrutinized, fitting Langmuir could well represent process. maximum capacity onto 108.69 mg g −1 . research using can greatly remove

Language: Английский

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Bystander effect of metal byproducts released from electroporated cells after electroporation in vitro

Bioelectrochemistry, Journal Year: 2025, Volume and Issue: 164, P. 108940 - 108940

Published: Feb. 13, 2025

Electrodes dissolution during electroporation releases metal ions into the medium, altering microenvironment of electroporated cells and allowing to penetrate cell membrane. During membrane repair, homeostasis restoration or activation death pathways, eliminate excess metals from cytoplasm This study assessed effects post-electroporation byproducts on untreated (non-electroporated) in vitro. CHO HCT116 were with three pulse protocols (unipolar: 100 μs, 5 ms; bipolar: 2 μs) using either aluminum stainless-steel electrodes. After electroporation, transferred fresh growth medium incubated for 4 h. Incubation period allowed recovery leading accumulation incubation medium. Stainless-steel electrodes ms protocol caused a considerable increase iron, chromium nickel compared other protocols. Metal toxicity non-electroporated cells, disrupting cycle function inducing death. The observed results combined cellular functions mechanisms use protect themselves overload.

Language: Английский

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Pharmacotherapeutic role of astringin against chromium induced nephrotoxicity via modulating TLR4/MyD88, HMGB1/RAGE and NF-κB pathway: A biochemical and pharmacokinetic approach

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: unknown, P. 127666 - 127666

Published: May 1, 2025

Language: Английский

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Dose-response effect of polyphenon-60 from green tea (P60-GT) on hexavalent chromium-induced genotoxic damage and apoptosis in mice

Journal of Toxicology and Environmental Health, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Jan. 24, 2025

This study aimed to examine the dose-response effects of polyphenon-60 derived from green tea (P60-GT) on hexavalent chromium [Cr(VI)]-induced genotoxic damage and apoptosis. Male Hsd:ICR mice were divided into 4 groups: (1) Control (vehicle only), (2) P60-GT (15, 30, or 45 mg/kg gavage), (3) Cr(VI) (20 CrO3 intraperitoneally), (4) P60-GT+CrO3 (P60-GT administered hr before CrO3). Peripheral blood samples collected at 24, 48, 72 assess number micronuclei (MN), apoptosis, cell viability, while plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels measured 0 48 hr. significantly increased MN frequency, suppressed 8-OHdG repair, reduced viability. Pre-treatment with frequency by up 74%, 30 dose demonstrating highest efficacy. restored enhanced suggesting activation DNA repair apoptotic pathways as potential antigenotoxic mechanisms. The 15 exhibited anti-apoptotic effects, doses promoted However, resulted in 100% lethality hr, likely due synergistic toxicity Cr(VI). These findings demonstrate dose-dependent protective emphasize need for dosage optimization maximize therapeutic benefits minimizing toxicity.

Language: Английский

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Cr(VI) induced hepatocyte apoptosis through the CTH/H2S/Drp1 signaling pathway

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 950, P. 175332 - 175332

Published: Aug. 6, 2024

Language: Английский

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Biosorption of Hexavalent Chromium by Shewanella putrefaciens MTCC 8104: Response Surface Methodology Optimization and Mechanistic Insights

Indian Journal of Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Language: Английский

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The SAM-Krom biomonitoring study shows occupational exposure to hexavalent chromium and increased genotoxicity in Denmark

International Journal of Hygiene and Environmental Health, Journal Year: 2024, Volume and Issue: unknown, P. 114444 - 114444

Published: Sept. 1, 2024

Language: Английский

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Green clay materials applied in packed bed columns for adsorption of hexavalent chromium from aqueous solutions

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 28, 2024

The removal of hazardous metal ions from polluted water is a crucial process aimed at enhancing quality. In this study, we conducted dynamic adsorption investigation utilizing natural green clay for the hexavalent chromium aqueous solutions. material underwent characterization through various techniques, including fluorescence spectrometry (XRF), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and nitrogen-physisorption (BET). Column tests sand mixtures were performed to evaluate sorption in systems. Adsorption conditions examined by varying initial Cr⁶⁺ concentration, flow rate column height. maximum purification was achieved concentration 50 mg/L, 3mL/min bed height 12 cm. mathematical models Bohart-Adams, Thomas, Yoon-Nelson employed analyze experimental data predict breakthrough curves continuous adsorption. Through comparison R² values, it determined that Thomas diffusion effectively capture accurately describe data. results obtained indicate potential expansion fixed-bed heavy metals treatment industrial-scale wastewater. Additionally, exhibited remarkable reusability showed promising characteristics environmental industrial applications.

Language: Английский

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