Discover Food,
Journal Year:
2024,
Volume and Issue:
4(1)
Published: Feb. 22, 2024
Abstract
Numerous
under-researched
edible
plants
are
present
in
the
desert
regions
of
world.
These
could
be
potential
candidates
to
ensure
food
security
and
provide
valuable
bioactive
compounds
through
diet.
In
general,
bioactives
manifest
synergistic,
additive,
or
antagonistic
interactions.
The
current
study
investigates
such
interactions
between
combinations
traditionally
consumed
(semi)
arid
regions.
Five
(representing
three
categories)
were
selected:
Prosopis
cineraria
Acacia
senegal
(legume),
Capparis
decidua
Cordia
dichotoma
(non-legume),
Mangifera
indica
(fruit),
which
first
four
largely
underutilized.
antioxidant
capacities
individual
plant
extracts
their
binary
mixtures
analyzed
by
DPPH
free
radical
scavenging
FRAP
assays.
total
phenolic
content
(TPC)
flavonoid
(TFC)
also
determined.
highest
activity
was
obtained
for
extract
(EC
50
—1.24
±
0.02
mg/ml,
value—380.58
11.17
μM/g),
while
exhibited
lowest
—2.54
0.05
value—48.91
4.34
μM/g).
Binary
mixture
(legume)
(fruit)
manifested
maximum
synergy
(experimental
EC
—0.89
0.01
theoretical
—3.79
mg/ml).
Correlation
studies
[Pearson’s
correlation
coefficient
(r)
Principal
component
analysis
(PCA)]
showed
a
high
TFC
with
TPC
values.
LC–MS
methanolic
detected
43
(including
acids,
flavonoids,
isoflavonoids),
possibly
responsible
observed
synergy.
For
zones,
this
is
first-of-its-kind
provides
scientific
validation
traditional
wisdom
consuming
these
foods
together.
Such
indigenous
derived
from
flora
offer
insights
into
development
sustainable
functional
nutraceuticals.
Graphical
Evidence-based Complementary and Alternative Medicine,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 16
Published: June 21, 2022
Diabetes
mellitus
(DM)
is
a
fatal
metabolic
disorder,
and
its
prevalence
has
escalated
in
recent
decades
to
greater
extent.
Since
the
incidence
severity
of
disease
are
constantly
increasing,
plenty
therapeutic
approaches
being
considered
as
promising
solution.
Many
dietary
polyphenols
have
been
reported
be
effective
against
diabetes
along
with
accompanying
vascular
consequences
by
targeting
multiple
targets.
Additionally,
biocompatibility
these
raises
questions
about
their
use
pharmacological
mediators.
Nevertheless,
pharmacokinetic
biopharmaceutical
properties
limit
clinical
benefit
therapeutics.
Pharmaceutical
industries
attempted
improve
compliance
effects.
However,
nanotechnological
overcome
barriers
associated
antidiabetic
medications
shown
efficacy.
Therefore,
this
review
highlighted
comprehensive
up-to-date
assessment
polyphenol
nanoformulations
treatment
consequences.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(19), P. 4573 - 4573
Published: Sept. 21, 2022
Despite
the
significant
advances
and
mechanistic
understanding
of
tumor
processes,
therapeutic
agents
against
different
types
cancer
still
have
a
high
rate
recurrence
associated
with
development
resistance
by
cells.
This
chemoresistance
involves
several
mechanisms,
including
programming
glucose
metabolism,
mitochondrial
damage,
lysosome
dysfunction.
However,
combining
anticancer
can
decrease
increase
efficacy.
Furthermore,
this
treatment
improve
effectiveness
chemotherapy.
work
focuses
on
recent
in
using
natural
bioactive
molecules
derived
from
phenolic
compounds
isolated
medicinal
plants
to
sensitize
cells
towards
chemotherapeutic
their
application
combination
conventional
drugs.
Dietary
such
as
resveratrol,
gallic
acid,
caffeic
rosmarinic
sinapic
curcumin
exhibit
remarkable
activities
through
sub-cellular,
cellular,
molecular
mechanisms.
These
recently
revealed
capacity
sensitivity
human
cancers
used
Moreover,
they
index
some
agents.
The
involved
mechanisms
are
complex
stochastic,
involve
signaling
pathways
checkpoints,
reactive
oxygen
species
mitochondria,
autophagy-related
pathways,
proteasome
oncogene
degradation,
epigenetic
perturbations.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4454 - 4454
Published: Feb. 23, 2023
Inflammatory
bowel
disease
(IBD)
is
a
group
of
disorders
that
cause
chronic
non-specific
inflammation
in
the
gastrointestinal
(GI)
tract,
primarily
affecting
ileum
and
colon.
The
incidence
IBD
has
risen
sharply
recent
years.
Despite
continuous
research
efforts
over
past
decades,
aetiology
still
not
fully
understood
only
limited
number
drugs
are
available
for
its
treatment.
Flavonoids,
ubiquitous
class
natural
chemicals
found
plants,
have
been
widely
used
prevention
treatment
IBD.
However,
their
therapeutic
efficacy
unsatisfactory
due
to
poor
solubility,
instability,
rapid
metabolism,
systemic
elimination.
With
development
nanomedicine,
nanocarriers
can
efficiently
encapsulate
various
flavonoids
subsequently
form
nanoparticles
(NPs),
which
greatly
improves
stability
bioavailability
flavonoids.
Recently,
progress
also
made
methodology
biodegradable
polymers
be
fabricate
NPs.
As
result,
NPs
significantly
enhance
preventive
or
effects
on
In
this
review,
we
aim
evaluate
effect
flavonoid
Furthermore,
discuss
possible
challenges
future
perspectives.
Journal of Physiology and Biochemistry,
Journal Year:
2024,
Volume and Issue:
80(3), P. 603 - 625
Published: Aug. 1, 2024
A
diet
rich
in
polyphenols
and
other
types
of
phytonutrients
can
reduce
the
occurrence
chronic
diseases.
However,
a
well-established
cause-and-effect
association
has
not
been
clearly
demonstrated
several
issues
will
need
to
be
fully
understood
before
general
recommendations
carried
out
In
present
review,
some
future
challenges
that
research
on
phenolic
compounds
have
face
next
years
are
discussed:
toxicological
aspects
safety
risk
assessment;
synergistic
effects
between
different
polyphenols;
metabotype-based
nutritional
advice
based
differential
gut
microbial
metabolism
(precision
nutrition);
combination
with
bioactive
compounds;
innovative
formulations
improve
bioavailability
sports
nutrition
recovery.Other
related
polyphenol
boost
are:
microbiota
crosstalk,
including
prebiotic
biotransformation
into
metabolites
by
microorganisms;
molecular
docking,
dynamics
simulation,
quantum
mechanics
studies
protein-polyphenol
complexes;
polyphenol-based
coating
films,
nanoparticles,
hydrogels
facilitate
delivery
drugs,
nucleic
acids
proteins.In
summary,
this
article
provides
constructive
inspirations
for
advancing
applications,
assessment
metabolic
dietary
humans.
Discover Food,
Journal Year:
2024,
Volume and Issue:
4(1)
Published: Feb. 22, 2024
Abstract
Numerous
under-researched
edible
plants
are
present
in
the
desert
regions
of
world.
These
could
be
potential
candidates
to
ensure
food
security
and
provide
valuable
bioactive
compounds
through
diet.
In
general,
bioactives
manifest
synergistic,
additive,
or
antagonistic
interactions.
The
current
study
investigates
such
interactions
between
combinations
traditionally
consumed
(semi)
arid
regions.
Five
(representing
three
categories)
were
selected:
Prosopis
cineraria
Acacia
senegal
(legume),
Capparis
decidua
Cordia
dichotoma
(non-legume),
Mangifera
indica
(fruit),
which
first
four
largely
underutilized.
antioxidant
capacities
individual
plant
extracts
their
binary
mixtures
analyzed
by
DPPH
free
radical
scavenging
FRAP
assays.
total
phenolic
content
(TPC)
flavonoid
(TFC)
also
determined.
highest
activity
was
obtained
for
extract
(EC
50
—1.24
±
0.02
mg/ml,
value—380.58
11.17
μM/g),
while
exhibited
lowest
—2.54
0.05
value—48.91
4.34
μM/g).
Binary
mixture
(legume)
(fruit)
manifested
maximum
synergy
(experimental
EC
—0.89
0.01
theoretical
—3.79
mg/ml).
Correlation
studies
[Pearson’s
correlation
coefficient
(r)
Principal
component
analysis
(PCA)]
showed
a
high
TFC
with
TPC
values.
LC–MS
methanolic
detected
43
(including
acids,
flavonoids,
isoflavonoids),
possibly
responsible
observed
synergy.
For
zones,
this
is
first-of-its-kind
provides
scientific
validation
traditional
wisdom
consuming
these
foods
together.
Such
indigenous
derived
from
flora
offer
insights
into
development
sustainable
functional
nutraceuticals.
Graphical
