Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2056 - 2056

Published: Nov. 29, 2023

Cancer is one of the most serious public health issues worldwide, demanding ongoing efforts to find novel therapeutic agents and approaches. Amid growing interest in oncological applications phytochemicals, particularly polyphenols, resveratrol-a naturally occurring polyphenolic stilbene derivative-has emerged as a candidate interest. This review analyzes pleiotropic anti-cancer effects resveratrol, including its modulation apoptotic pathways, cell cycle regulation, inflammation, angiogenesis, metastasis, interaction with cancer stem cells tumor microenvironment. The resveratrol on mitochondrial functions, which are crucial development, also discussed. Future research directions identified, elucidation specific molecular targets, facilitate clinical translation prevention therapy.

Language: Английский

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Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies—An Update Overview

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3746 - 3746

Published: April 26, 2023

This review article describes studies published over the past five years on combination of polyphenols, which are most studied in field anticancer effects (curcumin, quercetin, resveratrol, epigallocatechin gallate, and apigenin) chemotherapeutics such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, etc. According to WHO data, research has been limited cancers with highest morbidity rate (lung, colorectal, liver, gastric, breast cancer). A systematic articles (from January 2018 2023) was carried out help all Web Science databases available base clinical studies. Based preclinical presented this review, polyphenols can enhance drug efficacy reduce chemoresistance through different molecular mechanisms. Considering large number studies, curcumin could be a molecule future chemotherapy cocktails. One main problems is related bioavailability polyphenols. The design new co-delivery system for drugs essential research. Some work synergy chemotherapeutic drugs, but some act antagonistically, so caution always required.

Language: Английский

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Resveratrol as sensitizer in colorectal cancer plasticity

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 43(1), P. 55 - 85

Published: July 29, 2023

Abstract Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that be linked several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition the sentinel gene p53, apoptosis. As consequence, tumor cells escape effectiveness chemotherapeutic agents. This underscores need for cross-target therapeutic approaches are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize overcome standard drugs. In recent years, scientists have been searching natural compounds used chemosensitizers addition conventional medications synergistic CRC. Resveratrol, polyphenolic phytoalexin found various fruits vegetables such peanuts, berries, red grapes, is one most effective chemopreventive Abundant vitro vivo studies shown resveratrol, interaction with drugs, chemosensitizer CRC agents thus prevents drug by modulating pathways, transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, The ability resveratrol modify subcellular may suppress plasticity reversal critical parameters understanding its anti-cancer effects. this review, we focus on chemosensitizing properties and, thus, potential importance additive ongoing treatments. Graphical abstract

Language: Английский

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Antimicrobial, antioxidant, α-amylase and α-glucosidase inhibitory activities of a chemically characterized essential oil from Lavandula angustifolia Mill.,: in vitro and in silico investigations

Biochemical Systematics and Ecology, Journal Year: 2023, Volume and Issue: 111, P. 104731 - 104731

Published: Sept. 22, 2023

Language: Английский

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A review on the composition, extraction and applications of phenolic compounds

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Grass lignin: biosynthesis, biological roles, and industrial applications

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 23, 2024

Lignin is a phenolic heteropolymer found in most terrestrial plants that contributes an essential role plant growth, abiotic stress tolerance, and biotic resistance. Recent research grass lignin biosynthesis has differences compared to dicots such as Arabidopsis thaliana . For example, the prolific incorporation of hydroxycinnamic acids into secondary cell walls improve structural integrity vascular elements via covalent crosslinking. Conversely, fundamental monolignol chemistry conserves mechanisms translocation polymerization across phylum. Emerging evidence suggests compositions contribute periods often alter cereal hinder pathogenesis. This same recalcitrance also inhibits industrial valorization biomass, making alterations reductions field research. review presents update biosynthesis, translocation, polymerization, highlights how lignified development responses, briefly addresses genetic engineering strategies may benefit applications.

Language: Английский

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Tetraclinis articulata (Vahl) Mast. essential oil as a promising source of bioactive compounds with antimicrobial, antioxidant, anti-inflammatory and dermatoprotective properties: In vitro and in silico evidence

Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23084 - e23084

Published: Dec. 3, 2023

Tetraclinis articulata is a known traditional medicinal plant used to manage various ailments, such as diabetes, rheumatism and infectious diseases. This study aims determine the chemical constituents of T. essential oil (EO) evaluate its in vitro antibacterial, anti-candidal, antioxidant, anti-inflammatory dermatoprotective properties. In addition, computational docking approach was predict potential antifungal, anti-inflammatory, cytotoxic properties identified compounds. The volatile obtained by hydrodistillation characterized using gas chromatography-mass spectrometry (GC-MS). antioxidant activity EO investigated three complementary assays: DPPH, ABTS FRAP. Lipoxygenase (5-LOX) tyrosinase enzymes were assess effects this oil. Moreover, disc-diffusion technique, minimum inhibitory concentration (MIC) bactericidal (MBC) assays employed for antimicrobial screening. GC-MS analysis revealed that bornyl acetate (41.80 %), α-pinene (17.97 %) camphor (15.97 are major components studied EO. has exhibited promising effect on FRAP, experiments. It also significantly inhibited 5-LOX (IC50 = 67.82 ± 0.03 μg/mL) 211.93 0.02 μg/mL). results MIC MBC indicated able inhibit growth all tested bacteria (Gram + Gram -) Candida species. ratio tolerance level against species, whereas it bacteriostatic behavior Gram− bacteria. light these findings, may be suggested pharmaceutical agent prevent inflammation skin problems serve natural alternative sustainable application food products.

Language: Английский

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Phytochemical and biological characterization of aqueous extract of Vassobia breviflora on proliferation and viability of melanoma cells: involvement of purinergic pathway

Journal of Toxicology and Environmental Health, Journal Year: 2023, Volume and Issue: 86(17), P. 632 - 652

Published: July 11, 2023

Vassobia breviflora belongs to the Solanaceae family, possessing biological activity against tumor cells and is a promising alternative for therapy. The aim of this investigation was determine phytochemical properties V. using ESI-ToF-MS. cytotoxic effects extract were examined in B16-F10 melanoma relationship if any purinergic signaling involved. antioxidant total phenols, (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) analyzed, as well production reactive oxygen species (ROS) nitric oxide (NO) determined. Genotoxicity assessed by DNA damage assay. Subsequently, structural bioactive compounds docked purinoceptors P2X7 P2Y1 receptors. found N-methyl-(2S,4 R)-trans-4-hydroxy-L-proline, calystegine B, 12-O-benzoyl- tenacigenin A bungoside B. In vitro cytotoxicity demonstrated at concentration ranges 0.1–10 mg/ml, plasmid breaks only 10 mg/ml. extracts affected hydrolysis ectoenzymes, such ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) ectoadenosine deaminase (E-ADA) which control levels degradation formation nucleosides nucleotides. presence substrates ATP, ADP, AMP adenosine, activities E-NTPDase, 5´-NT or E-ADA significantly modulated breviflora. R)-trans-4-hydroxy-L-proline presented higher binding affinity (according receptor-ligand complex estimated evidenced ∆G values) bind both P2Y1purinergic receptors.Our results suggest putative interaction with growth inhibitory potential that may be considered cancer treatment

Language: Английский

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Studies on the mechanism of ototoxic action of cisplatin and the antagonistic effect of polyphenolic compounds

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Cisplatin is a highly effective broad-spectrum anticancer drug, but its severe ototoxicity limits clinical application. mainly manifested as irreversible hearing loss, and mechanism involves various pathways such DNA damage, oxidative stress, inflammatory response, mitochondrial dysfunction, ferroptosis. In recent years, natural polyphenols have shown great potential in combating cisplatin due to their powerful antioxidant, anti-inflammatory anti-apoptotic properties.A variety of polyphenolic compounds, resveratrol, curcumin, quercetin, etc., can effectively attenuate the damage on Corti organs, spiral ganglion neurons vascular striatum by scavenging free radicals, inhibiting release factors, regulating expression apoptosis-related proteins. addition, some enhance anti-tumour effect while antagonizing ototoxicity.Although show good application prospects prevention treatment ototoxicity, there are still problems that need be solved, low bioavailability polyphenols, action has not yet been fully elucidated, optimal dosing regimen determined, whether any superimposed combining types oral exert an otoprotective through regulation intestinal flora intestinal-auricular axis.This study provides new insights into drug candidates for CIO summarising cytotoxic mechanisms targeting these order retard progression CIO. It ideas approaches next step focusing development low-toxic control ototoxicity.

Language: Английский

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Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1117 - 1117

Published: Aug. 8, 2023

Africa is home to diverse medicinal plants that have been used for generations the treatment of several different cancers and, presently, they are gaining interest from researchers as promising approaches cancer treatment. This review aims provide a comprehensive dietary and African fruits including their traditional uses, botanical description, ethnobotanical bioactive phytochemical compositions, anticancer properties investigated date in vitro, vivo, clinical studies. Data on recent updates concerning uses these were collected myriad available publications electronic databases, such Web Science, PubMed, ScienceDirect, Scopus, SpringerLink, Google Scholar. The results suggest approximately 12 native or commercially grown belonging plant species, Tribulus terrestris, Xanthium strumarium, Withania somnifera, Xylopia aethiopica, Abelmoschus esculentus, Carissa macrocarpa, Carpobrotus edulis, Syzygium cumini, Kigelia Africana, Annona muricata, Persea americana, Punica granatum, reported potential options management cancer. We further found eight species Africa, namely, Sclerocarya birrea, Dovyalis caffra, Parinari curatellifolia, Mimusops Vangueria infausta, Harpephyllum caffrum, widely ailments but somehow failed gain use research. In this review, we show various agents, granatum; unfortunately, not enough research data published thorough mechanistic insights applications. Additionally, discuss possibility utilization phytochemicals like americana granatum research, well future directions.

Language: Английский

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