Development of functional spermatozoa in mammalian spermiogenesis
Development,
Journal Year:
2024,
Volume and Issue:
151(14)
Published: July 15, 2024
ABSTRACT
Infertility
is
a
global
health
problem
affecting
one
in
six
couples,
with
50%
of
cases
attributed
to
male
infertility.
Spermatozoa
are
gametes,
specialized
cells
that
can
be
divided
into
two
parts:
the
head
and
flagellum.
The
contains
vesicle
called
acrosome
undergoes
exocytosis
flagellum
motility
apparatus
propels
spermatozoa
forward
components,
axonemes
accessory
structures.
For
fertilize
oocytes,
must
formed
correctly.
In
this
Review,
we
describe
comprehensively
how
functional
develop
mammals
during
spermiogenesis,
including
formation
acrosomes,
structures
by
focusing
on
analyses
mouse
models.
Language: Английский
The annulus: composition, role and importance in sperm flagellum biogenesis and male fertility
Basic and Clinical Andrology,
Journal Year:
2024,
Volume and Issue:
34(1)
Published: Dec. 15, 2024
Abstract
The
annulus
is
an
electron-dense
ring
structure
that
surrounds
the
axoneme
and
compartmentalizes
sperm
flagellum
into
two
parts:
midpiece
principal
piece.
function
of
as
a
diffusion
barrier
in
mature
spermatozoon
now
well
described
but
its
during
spermiogenesis
remains
unclear.
intriguing
spatio-temporal
dynamics
position
at
interface
main
flagellar
compartments
have
been
highlighted
for
more
than
50
years,
suggest
major
role
this
process.
During
last
decade,
numerous
studies
contributed
establishing
repertoire
proteins
known
to
be
located
annulus.
Mutant
mouse
models
invalidation
these
provided
essential
information
clues
novel
hypotheses
regarding
functions
regulation
structure.
Importantly,
recent
identification
humans
homozygous
mutations
genes
coding
leading
sterility
reinforced
importance
physiology
male
fertility.
This
review
provides
comprehensive
description
all
knowledge
obtained
several
years
composition
functions,
both
mice
humans.
Language: Английский
Centriolar appendages evolve into the inner sheath of mammalian flagella
The Journal of Cell Biology,
Journal Year:
2024,
Volume and Issue:
223(3)
Published: Feb. 21, 2024
The
annulus,
a
septin-based
structure
in
vertebrate
sperm
connecting
the
MP
and
PP,
has
unclear
migration
mechanics.
In
this
issue,
Hoque
et
al.
(https://doi.org/10.1083/jcb.202307147)
report
that
CBY3/CIBAR1
complex
ensures
its
precise
positioning
by
regulating
membrane
properties.
Language: Английский
ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance
Life Science Alliance,
Journal Year:
2024,
Volume and Issue:
8(2), P. e202402916 - e202402916
Published: Dec. 2, 2024
Bin/Amphiphysin/Rvs
(BAR)
domains
are
highly
conserved
found
in
all
eukaryotes.
BAR
domain
proteins
form
crescent-shaped
dimers
that
sense
and
sculpt
curved
lipid
membranes
play
key
roles
various
cellular
processes.
However,
their
functions
mammalian
development
poorly
understood.
We
previously
demonstrated
Chibby1-interacting
domain–containing
1
(ciBAR1,
formerly
known
as
FAM92A)
localizes
to
the
ciliary
base
plays
a
critical
role
ciliogenesis.
Here,
we
report
ciliopathy
phenotypes
of
ciBAR1
-KO
mice.
∼28%
mice
show
embryonic
lethality
because
randomized
left–right
asymmetry;
rest
survive
into
adulthood
with
no
gross
morphological
abnormalities.
Histological
assessments
ciliated
tissues
revealed
exocrine
pancreatic
lesions.
Although
overall
endocrine
islet
morphology
appeared
be
normal,
showed
impaired
glucose
tolerance.
Examination
ductal
cilia
number
length
were
significantly
reduced
pancreata.
MEFs
also
exhibited
defects.
Our
findings
indicate
ciliogenesis
depending
on
tissue
cell
type
Language: Английский