Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: May 8, 2024
Targeted therapy has become crucial to modern translational science, offering a remedy conventional drug delivery challenges. Conventional systems encountered challenges related solubility, prolonged release, and inadequate penetration at the target region, such as tumor. Several formulations, liposomes, polymers, dendrimers, have been successful in advancing clinical trials with goal of improving drug’s pharmacokinetics biodistribution. Various stealth coatings, including hydrophilic polymers PEG, chitosan, polyacrylamides, can form protective layer over nanoparticles, preventing aggregation, opsonization, immune system detection. As result, they are classified under Generally Recognized Safe (GRAS) category. Serum, biological sample, complex composition. Non-specific adsorption chemicals onto an electrode lead fouling, impacting sensitivity accuracy focused diagnostics therapies. anti-fouling materials procedures developed minimize impact fouling on specific diagnoses therapies, leading significant advancements recent decades. This study provides detailed analysis current methodologies using surface modifications that leverage antifouling properties peptides, proteins, cell membranes for advanced targeted cancer treatment. In conclusion, we examine obstacles by present technologies possible avenues future development.
Language: Английский