HIF Transcription Factors, Inflammation, and Immunity

Immunity, Journal Year: 2014, Volume and Issue: 41(4), P. 518 - 528

Published: Oct. 1, 2014

Language: Английский

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The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

Cell Metabolism, Journal Year: 2014, Volume and Issue: 20(1), P. 61 - 72

Published: June 12, 2014

Language: Английский

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T cell metabolism drives immunity

The Journal of Experimental Medicine, Journal Year: 2015, Volume and Issue: 212(9), P. 1345 - 1360

Published: Aug. 10, 2015

Lymphocytes must adapt to a wide array of environmental stressors as part their normal development, during which they undergo dramatic metabolic remodeling process. Research in this area has yielded surprising findings on the roles diverse pathways and metabolites, have been found regulate lymphocyte signaling influence differentiation, function fate. In review, we integrate latest field provide an up-to-date resource metabolism.

Language: Английский

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Metabolic Instruction of Immunity

Cell, Journal Year: 2017, Volume and Issue: 169(4), P. 570 - 586

Published: May 1, 2017

Language: Английский

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Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

Frontiers in Immunology, Journal Year: 2015, Volume and Issue: 6

Published: Jan. 22, 2015

The adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex coordinated signals drive the activation, proliferation differentiation appropriate T cell subsets. now established that changes in cellular activation are coupled profound metabolism. In addition, emerging evidence suggest specific metabolic alterations associated with distinct subsets may be ancillary their influential functions. "Warburg effect" originally used describe phenomenon which most cancer cells relied on aerobic glycolysis for growth key process sustain differentiation. Here we review how different aspects metabolism influence functions, focusing role regulators glucose such as HIF-1α. A thorough understanding function could provide insights into mechanisms involved inflammatory-mediated conditions, potential developing novel therapeutic approaches treat these diseases.

Language: Английский

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Regulation and function of mTOR signalling in T cell fate decisions

Nature reviews. Immunology, Journal Year: 2012, Volume and Issue: 12(5), P. 325 - 338

Published: April 20, 2012

Language: Английский

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Commensal bacteria at the interface of host metabolism and the immune system

Nature Immunology, Journal Year: 2013, Volume and Issue: 14(7), P. 676 - 684

Published: June 18, 2013

Language: Английский

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Butyrate: A Double-Edged Sword for Health?

Advances in Nutrition, Journal Year: 2018, Volume and Issue: 9(1), P. 21 - 29

Published: Jan. 1, 2018

Language: Английский

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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

Journal of Clinical Investigation, Journal Year: 2013, Volume and Issue: 123(10), P. 4479 - 4488

Published: Sept. 15, 2013

Naive CD8+ T cells rely upon oxidation of fatty acids as a primary source energy. After antigen encounter, shift to glycolytic metabolism sustain effector function. It is unclear, however, whether changes in glucose ultimately influence the ability activated become long-lived memory cells. We used fluorescent analog, 2-NBDG, quantify uptake found that exhibiting limited incorporation had molecular profile characteristic precursor and an increased capacity enter pool compared with taking up high amounts glucose. Accordingly, enforcing by overexpressing enzyme phosphoglycerate mutase-1 severely impaired form long-term memory. Conversely, activation presence inhibitor glycolysis, 2-deoxyglucose, enhanced generation antitumor functionality. Our data indicate augmenting flux drives toward terminally differentiated state, while its inhibition preserves formation These results have important implications for improving efficacy cell-based therapies against chronic infectious diseases cancer.

Language: Английский

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Mitochondria in the Regulation of Innate and Adaptive Immunity

Immunity, Journal Year: 2015, Volume and Issue: 42(3), P. 406 - 417

Published: March 1, 2015

Language: Английский

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