All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity DOI Creative Commons
Ariel Ramírez-Labrada, Cecilia Pesini, Llipsy Santiago

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 16, 2022

NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and transformed cells, being one the main executors cell death in system. recognize target through an array inhibitory activating receptors for endogenous or exogenous pathogen-derived ligands, which together with adhesion molecules form a structure known as immunological synapse that regulates effector functions. The best characterized mechanisms involved granule exocytosis pathway (perforin/granzymes) expression ligands. These pathways recognized activators different programmes on leading to their destruction. However, most studies analyzing these have used pure recombinant native proteins instead intact and, thus, extrapolation results might be difficult. Specially, since activation and/or ligands during elimination influenced by stimulus received from other microenvironment components, affect activated cells. Here we will review discuss available experimental evidence how kill special focus modalities been found cytotoxicity; including apoptosis more inflammatory like necroptosis pyroptosis. In light this new evidence, develop concept induced regulatory mechanism linking innate response tumour adaptive T responses, initiating trigger cancer-immunity cycle. use modulation molecular machinery regulating them not only but, addition, generation responses against would contribute efficient generate cancer memory preventing potential recurrences.

Language: Английский

Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment DOI
Xiaoli Wu, Han Yang,

Xingmeng Chen

et al.

Biomaterials, Journal Year: 2021, Volume and Issue: 269, P. 120654 - 120654

Published: Jan. 7, 2021

Language: Английский

Citations

84
Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer DOI Creative Commons
Ina Bähr, Julia Spielmann, Dagmar Quandt

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: March 13, 2020

Obesity is accompanied by a systemic chronic low-grade inflammation as well dysfunctions of several innate and adaptive immune cells. Recent findings emphasize an impaired functionality phenotype natural killer (NK) cells under obese conditions. This review provides detailed overview on research related to overweight obesity with particular focus NK We discuss obesity-associated alterations in subsets, distribution, cytotoxicity, cytokine secretion signaling cascades investigated vitro animal human studies. In addition, we provide recent insights into effects physical activity, nutritional factors the reduction body weight fat mass cell functions individuals. Finally, highlight impact physiology diseases focusing elevated susceptibility for viral infections increased risk cancer development treatment response.

Language: Английский

Citations

82
The Dual Roles of Human γδ T Cells: Anti-Tumor or Tumor-Promoting DOI Creative Commons
Yang Li, Gen Li, Jian Zhang

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 11

Published: Feb. 16, 2021

γδ T cells are the unique cell subgroup with their receptors composed of γ chain and δ chain. Unlike αβ cells, non-MHC-restricted in recognizing tumor antigens, therefore defined as innate immune cells. Activated can promote anti-tumor function adaptive They considered a bridge between immunity immunity. However, several other studies have shown that also progression by inhibiting response. Therefore, may both tumor-promoting effects. In order to clarify this contradiction, review, we summarized functions main subsets human how they exhibit respective or pro-tumor effects cancer. Then, reviewed recent cell-based immunotherapy. Finally, existing problems prospect

Language: Английский

Citations

69
The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic DOI Creative Commons
Nandeeta Samad, Temitayo Eniola Sodunke, Abdullahi Rabiu Abubakar

et al.

Journal of Inflammation Research, Journal Year: 2021, Volume and Issue: Volume 14, P. 527 - 550

Published: Feb. 1, 2021

The global pandemic from COVID-19 infection has generated significant public health concerns, both health-wise and economically. There is no specific pharmacological antiviral therapeutic option to date available for management. Also, there an urgent need discover effective medicines, prevention, control methods because of the harsh death toll this novel coronavirus infection. Acute respiratory tract infections, significantly lower pneumonia are primary cause millions deaths worldwide. role micronutrients, including trace elements, boosted human immune system was well established. Several vitamins such as vitamin A, B6, B12, C, D, E, folate; microelement zinc, iron, selenium, magnesium, copper; omega-3 fatty acids eicosapentaenoic acid docosahexaenoic plays essential physiological roles in promoting system. Furthermore, zinc indispensable a thorough enzymatic process. It also helps regulate gene-transcription DNA replication, RNA transcription, cell division, activation biological Subsequently, together with natural scavenger cells neutrophils, involved developing responsible regulating nonspecific immunity. modern food habit often promotes deficiency; such, quite few patients presented hospitals were frequently diagnosed deficient. Earlier studies documented that deficiency predisposes viral herpes simplex, common cold, hepatitis severe acute syndrome (SARS-CoV-1), immunodeficiency virus (HIV) reducing This manuscript aimed discuss various played by management

Language: Английский

Citations

63
All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity DOI Creative Commons
Ariel Ramírez-Labrada, Cecilia Pesini, Llipsy Santiago

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 16, 2022

NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and transformed cells, being one the main executors cell death in system. recognize target through an array inhibitory activating receptors for endogenous or exogenous pathogen-derived ligands, which together with adhesion molecules form a structure known as immunological synapse that regulates effector functions. The best characterized mechanisms involved granule exocytosis pathway (perforin/granzymes) expression ligands. These pathways recognized activators different programmes on leading to their destruction. However, most studies analyzing these have used pure recombinant native proteins instead intact and, thus, extrapolation results might be difficult. Specially, since activation and/or ligands during elimination influenced by stimulus received from other microenvironment components, affect activated cells. Here we will review discuss available experimental evidence how kill special focus modalities been found cytotoxicity; including apoptosis more inflammatory like necroptosis pyroptosis. In light this new evidence, develop concept induced regulatory mechanism linking innate response tumour adaptive T responses, initiating trigger cancer-immunity cycle. use modulation molecular machinery regulating them not only but, addition, generation responses against would contribute efficient generate cancer memory preventing potential recurrences.

Language: Английский

Citations

63