Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 6803 - 6803

Published: June 24, 2021

Adequate amounts of a wide range micronutrients are needed by body tissues to maintain health. Dietary intake must be sufficient meet these micronutrient requirements. Mineral deficiency does not seem the result physically active life or athletic training but is more likely arise from disturbances in quality and quantity ingested food. The lack some minerals appears symbolic modern era reflecting either excessive empty calories negative energy balance drastic weight-loss diets. Several animal studies provide convincing evidence for an association between dietary availability microbial composition gut. However, influence human gut microbiota on bioaccessibility bioavailability trace elements food has rarely been studied. Bacteria play role effecting mineral bioaccessibility, which further increased through fermentation cereals soaking germination crops. Moreover, probiotics have positive effect iron, calcium, selenium, zinc relation microbiome metabolism. current literature reveals beneficial effects bacteria supporting both overall This review focuses interactions several sport nutrition, as related lifestyle.

Language: Английский

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The impact of the COVID-19 pandemic on lifestyle behaviors in children and adolescents: an international overview

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2022, Volume and Issue: 48(1)

Published: Feb. 4, 2022

The adverse effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) are not limited to the related infectious disease. In children and adolescents, serious risks due coronavirus disease 2019 (COVID-19) pandemic also its indirect effects. These include an unbalanced diet with increased risk weight excess or nutritional deficiencies, sedentary lifestyle, lack schooling, social isolation, impaired mental health.Pediatricians should be aware side COVID-19 on children's diet, physical health advise families according their needs financial resources. Moreover, a targeted therapy able offer protection against deleterious SARS-CoV-2 infection require greater effort by scientific societies find more effective prevention strategy. this context, much interest given support, contrast malnutrition stimulate immune system.

Language: Английский

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Attenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications

Journal of Inflammation Research, Journal Year: 2021, Volume and Issue: Volume 14, P. 1487 - 1510

Published: April 1, 2021

Abstract: The COVID-19 pandemic constitutes an arduous global health challenge, and the increasing number of fatalities calls for speedy pursuit a remedy. This review emphasizes changing aspects disease, featuring cytokine storm's pathological processes. Furthermore, we briefly reviewed potential therapeutic agents that may modulate alleviate storms. literature exploration was made using PubMed, Embase, MEDLINE, Google scholar, China National Knowledge Infrastructure databases to retrieve most recent on etiology, diagnostic markers, possible prophylactic options management storm in patients hospitalized with disease. causative agent, severe acute respiratory coronavirus-2 (SARS-CoV-2), continually threatens efficiency immune system infected individuals. As first responder, innate provides primary protection against COVID-19, affecting disease's progression, clinical outcome, prognosis. Evidence suggests associated are primarily due hyper-inflammation aberrant function. Accordingly, magnitude release pro-inflammatory cytokines such as interleukin (IL)-1, (IL-6), tumor necrosis alpha (TNF-α) significantly differentiate between mild cases COVID-19. early prediction is by several serum chemistry hematological markers. prompt use these markers diagnosis aggressive prevention syndrome critical determining level morbidity fatality prophylaxis rapid treatment clinicians will enhance fight dreaded Keywords: SARS-CoV-2, storm, hyper-inflammation,

Language: Английский

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Global Dietary and Herbal Supplement Use during COVID-19—A Scoping Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 771 - 771

Published: Feb. 2, 2023

During the first year of COVID-19 pandemic, lack cure and intensity global spread raised a common awareness health. The aim this scoping review is to summarize dietary supplement use globally during two years pandemic. A systematic search was conducted in December 2021 following PRISMA guidelines. PubMed, ERIC, Scopus databases were searched, 956 results screened for eligibility. Fourteen cross-sectional studies from 11 countries 3 continents examined. All large population surveys investigating healthy eating COVID-19. Vitamin C, vitamin D, zinc multivitamins most widely reported, as well natural/herbal products such ginger honey. reason cited supplements strengthen immune system prevent infection These reported that populations are relying on healthcare providers, family, friends, social media learn about use. Future treatment should include more evidence

Language: Английский

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Evaluation of the relationship between serum levels of zinc, vitamin B12, vitamin D, and clinical outcomes in patients with COVID‐19

Journal of Medical Virology, Journal Year: 2021, Volume and Issue: 94(1), P. 141 - 146

Published: Aug. 18, 2021

Due to the known anti-inflammatory and antiviral effects of zinc, 25(OH)D, vitamin B12, in this study, we explored association between serum levels these micronutrients coronavirus disease 2019 (COVID-19) patients at time admission clinical outcomes. This study was carried out on 293 with COVID-19, who were hospitalized Imam Hassan hospital (Bojnourd, Iran). We collected demographic data, characteristics, values biochemical parameters first week admission, outcomes from electronic medical records. also measured B12 within 3 days admission. Of hospitalized, median age 53 years, 147 (50.17%) female. Thirty-seven (12.62%) admitted intensive care unit (ICU), forty-two (14.32%) died. found that 25(OH)D lower died than those ICU or non-ICU survived; however, differences not statistically significant for (p > 0.05). The concentrations did affect length stay COVID-19. In general, it seems especially zinc can COVID-19 patients.

Language: Английский

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Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 457, P. 214402 - 214402

Published: Jan. 25, 2022

Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle current pandemic caused by SARS-CoV-2 is one of main targets among scientific community. In this regard, experts from different fields have gathered confront catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving difficult situation, state art Zn-based nanostructures are discussed detail. For virus detection, learning experience other respiratory such as influenza, potential use Zn nanomaterials suitable sensing platforms recognize S1 spike protein shown. Furthermore, discussion about antiviral mechanisms reported for ZnO included, which can help develop surface disinfectants protective coatings. At same time, properties materials supplements reducing viral activity recovery infected patients illustrated. Within scope noble adjuvants improve immune response, NPs immunomodulators explained, prototypes nanoengineered particles with metallic cations (like

Language: Английский

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Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19

Clinics in Geriatric Medicine, Journal Year: 2022, Volume and Issue: 38(3), P. 565 - 591

Published: June 20, 2022

Language: Английский

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Analysis of Neurological Adverse Events Reported in VigiBase From COVID-19 Vaccines

Cureus, Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 18, 2022

Fifteen COVID-19 vaccines have been granted emergency approval before the completion of conventional phases clinical trials. The present study aimed to analyze neurological adverse events (AEs) post-COVID-19 vaccination and focuses on determining association AEs with vaccine.

Language: Английский

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Course and Survival of COVID-19 Patients with Comorbidities in Relation to the Trace Element Status at Hospital Admission

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3304 - 3304

Published: Sept. 22, 2021

Selenium (Se) and zinc (Zn) are essential trace elements needed for appropriate immune system responses, cell signalling anti-viral defence. A cross-sectional observational study was conducted at two hospitals in Ghent, Belgium, to investigate whether Se and/or Zn deficiency upon hospital admission correlates disease severity mortality risk COVID-19 patients with or without co-morbidities. Trace element concentrations along additional biomarkers were determined serum plasma associated outcome. An insufficient status a higher rate more severe course the entire group, especially senior population. In comparison healthy European adults, displayed strongly depressed total (mean ± SD: 59.2 20.6 vs. 84.4 23.4 µg L−1) SELENOP 2.2 1.9 4.3 1.0 mg admission. Particularly strong associations observed death of cancer, diabetes chronic cardiac low status, obese deficiency. composite biomarker based on Se, proved be reliable tool predict death, mild course. We conclude that assessment may contribute better stratification other similar infectious diseases, support clinical care, therapeutic interventions adjuvant supplementation needs, prove particular relevance relevant comorbidities.

Language: Английский

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Effectiveness of Ivermectin-Based Multidrug Therapy in Severely Hypoxic, Ambulatory COVID-19 Patients

Future Microbiology, Journal Year: 2022, Volume and Issue: 17(5), P. 339 - 350

Published: Feb. 9, 2022

Aims: Ivermectin is a safe, inexpensive and effective early COVID-19 treatment validated in 20+ random, controlled trials. Having developed combination therapies for Helicobacter pylori, the authors present highly therapeutic combination, stemming from clinical observations. Patients & methods: In 24 subjects refusing hospitalization with high-risk features, hypoxia untreated moderate to severe symptoms averaging 9 days, administered this novel of ivermectin, doxycycline, zinc vitamins D C. Results conclusions: All resolved (in 11 days on average), oxygen saturation improved h (87.4% 93.1%; p = 0.001). There were no hospitalizations or deaths, less than (p < 0.002 0.05, respectively) background-matched CDC database controls. Triple therapy safe even when used outpatients symptoms. Clinical Trial Registration: NCT04482686 (ClinicalTrial.gov).

Language: Английский

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