The IL-17 family in diseases: from bench to bedside

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Oct. 11, 2023

Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members this various biological functions, including driving an inflammatory cascade during infections autoimmune diseases, as well boosting protective immunity against pathogens. is a highly versatile proinflammatory cytokine necessary for vital processes host immune defenses, tissue repair, disease pathogenesis, cancer progression. However, how performs these functions remains controversial. multifunctional properties attracted research interest, emerging data gradually improved our understanding the signaling pathway. comprehensive review required to understand role in both defense pathogenesis body. This can aid researchers better mechanisms underlying IL-17’s roles vivo provide theoretical basis future studies aiming regulate expression function. discusses recent progress pathway physiological roles. In addition, we present mechanism pathologies, particularly, IL-17-induced systemic lupus erythematosus IL-17-related tumor cell transformation metastasis. briefly discussed promising developments diagnosis treatment diseases tumors.

Language: Английский

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Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 22, 2023

Psoriasis is a common chronic inflammatory skin disease, associated with substantial comorbidity. TH17 lymphocytes, differentiating under the influence of dendritic cell-derived IL-23, and mediating their effects via IL-17A, are believed to be central effector cells in psoriasis. This concept underlined by unprecedented efficacy therapeutics targeting this pathogenetic axis. In recent years, numerous observations made it necessary revisit refine simple “linear” model. It became evident that IL-23 independent exist produce IL-17 homologues may exhibit synergistic biological effects, blockade IL-17A alone clinically less effective compared inhibition several homologues. review, we will summarize current knowledge around its five currently known homologues, namely IL-17B, IL-17C, IL-17D, IL-17E (also as IL-25) IL-17F, relation inflammation general psoriasis particular. We also re-visit above-mentioned integrate them into more comprehensive help appreciate well developing anti-psoriatic therapies prioritize selection future drugs’ mode(s) action.

Language: Английский

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Gingerenone A Attenuates Ulcerative Colitis via Targeting IL‐17RA to Inhibit Inflammation and Restore Intestinal Barrier Function

Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)

Published: April 19, 2024

Abstract Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available drugs for UC treatment are scarce, therefore, novel therapeutic the urgently to be developed. Gingerenone A (GA) phenolic compound known its anti‐inflammatory effect, but effect on remains unknown. Here, it shown that GA protects mice against UC, which closely associated with inhibiting mucosal inflammation enhancing barrier integrity in vivo vitro. Of note, RNA sequencing analysis demonstrates an evident correlation IL‐17 signaling pathway after treatment, this further corroborated by Western blot. Mechanistically, directly interacts IL‐17RA protein through pull‐down, surface plasmon resonance molecular dynamics simulation. Importantly, lentivirus‐mediated IL‐17RA/Act1 knock‐down or co‐treatment brodalumab/ixekizumab significantly impairs protective effects of DSS‐induced dysfunction, suggesting critical role GA‐mediated protection UC. Overall, these results indicate effective agent mainly direct binding inhibit inflammatory activation.

Language: Английский

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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 14, 2025

Language: Английский

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Interleukin-17 as a key player in neuroimmunometabolism

Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(7), P. 1088 - 1100

Published: July 20, 2023

Language: Английский

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Advances in the study of IL-17 in neurological diseases and mental disorders

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 16, 2023

Interleukin-17 (IL-17), a cytokine characteristically secreted by T helper 17 (Th17) cells, has attracted increasing attention in recent years because of its importance the pathogenesis many autoimmune or chronic inflammatory diseases. Recent studies have shown that neurological diseases and mental disorders are closely related to immune function, varying degrees dysregulation may disrupt normal expression molecules at critical stages neural development. Starting from relevant mechanisms affecting regulation, this article reviews research progress IL-17 selected group (autism spectrum disorder, Alzheimer’s disease, epilepsy, depression) perspective neuroinflammation microbiota–gut–brain axis, summarizes commonalities, provides prospective outlook target application disease treatment.

Language: Английский

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Network Pharmacology and Molecular Docking: Exploring the Mechanism of Peppermint in Mastitis Prevention and Treatment in Dairy Cows

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(2), P. 129 - 129

Published: Feb. 5, 2025

In order to elucidate the active ingredients, potential targets, and mechanisms of action peppermint in treating bovine mastitis, this study utilized network pharmacology analysis molecular docking conduct an exploratory, prospective investigation. Using Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, all compounds targets were retrieved. After removing duplicates, a total 133 272 obtained. Targets then standardized gene names using UniProt database construct drug–component-target network. A 183 disease related mastitis retrieved from GeneCards database. We obtained 28 cross constructed protein–protein interaction (PPI) STRING visual was built Cytoscape 3.10.0 software, seven core analyzed GO KEGG pathway enrichment performed Metascape Molecular conducted AutoDockTools–1.5.6 software on some small–molecule evaluate stability binding between targets. Apigenin, luteolin, ursolic acid are three main components peppermint. Core (TNF, IL–6, STAT–3, IL–1β, FGF–2, IFNG, ESR–1) selected based PPI The suggested that major signaling pathways may include AGEs–RAGE, IL–17, NF–κB, TLRs, HIF–1, TGF–β, PI3K–Akt, MAPK. results showed one mint, acid, exhibited good activity with mastitis. Other constituents also produced favorable This elucidates mint providing data support development new therapies for its constituents.

Language: Английский

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Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(10), P. 1767 - 1781.e6

Published: Oct. 1, 2023

Pseudomonas aeruginosa is a common cause of pulmonary infection. As Gram-negative pathogen, it can initiate brisk and highly destructive inflammatory response; however, most hosts become tolerant to the bacterial burden, developing chronic Using murine model pneumonia, we demonstrate that this shift from inflammation disease tolerance promoted by ketogenesis. In response infection, ketone bodies are generated in liver circulate lungs where they impose selection for P. strains unable display surface lipopolysaccharide (LPS). Such keto-adapted LPS fail activate glycolysis tissue-damaging cytokines and, instead, facilitate mitochondrial catabolism fats oxidative phosphorylation (OXPHOS), which maintains airway homeostasis. Within lung, exploits host immunometabolite itaconate further stimulate This environment enables host-P. coexistence, supporting both pathoadaptive changes bacteria maintenance respiratory integrity via OXPHOS.

Language: Английский

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Molecular mechanism of Jianpiyifei II granules in the treatment of chronic obstructive pulmonary disease: Network pharmacology analysis, molecular docking, and experimental assessment

Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155273 - 155273

Published: Jan. 6, 2024

Language: Английский

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IL-17 Control of Cutaneous Immune Homeostasis

Journal of Investigative Dermatology, Journal Year: 2024, Volume and Issue: 144(6), P. 1208 - 1216

Published: April 26, 2024

Language: Английский

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