Case report: Carnivore–ketogenic diet for the treatment of inflammatory bowel disease: a case series of 10 patients

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 2, 2024

Very-low-carbohydrate diets, including ketogenic and carnivore are gaining popularity for the experimental treatment of a wide range disorders, inflammatory bowel disease (IBD).

Language: Английский

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Electron Reservoir MoO_3–x‐Driven Cu⁺ Doped Nanozyme with Enhanced Antibacterial Activity via Disrupting Redox Homeostasis

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(18), P. 2187 - 2196

Published: May 14, 2024

Comprehensive Summary Redox nanozymes offer an appealing reactive oxygen species (ROS)‐based antibacterial strategy via disrupting intracellular homeostasis, however, they still face many obstacles such as low enzymic activity and irreversible loss of catalytic active center. Meanwhile, the antioxidant glutathione (GSH) overexpressed in infected sites would limit therapy efficiency. Herein, we develop a multifunctional nanozyme based on copper(I) (Cu + ) ion doped MoO 3– x ‐MoO by simple yet efficient vacancy‐reduced without any pretreatment or additional agents. The resultant Cu hybrid possesses enhanced peroxidase‐like (POD‐like) activity, rapid GSH‐depleting function biodegradable ability. It can achieve highly elimination Pseudomonas aeruginosa ( P. cellular redox balance. More intriguingly, reaction between GSH could translate Mo 6+ into 5+ , thereby leading to partial recovery POD‐like for continuous ∙ OH generation. In vitro vivo experiments demonstrated that had stronger property compared consumption plentiful generation providing extra H 2 O well neglective toxicity healthy organs. view its remarkable good biosafety, developed be used promising antimicrobial infection.

Language: Английский

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Ketogenesis favors oxidative phosphorylation to promote disease tolerance

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(3), P. 177 - 179

Published: Jan. 31, 2024

Language: Английский

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Disruption of glucose homeostasis by bacterial infection orchestrates host innate immunity through NAD+/NADH balance

Cell Reports, Journal Year: 2024, Volume and Issue: 43(9), P. 114648 - 114648

Published: Aug. 20, 2024

Metabolic reprogramming is crucial for activating innate immunity in macrophages, and the accumulation of immunometabolites essential effective defense against infection. The NAD

Language: Английский

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Ketogenesis nutritionally supports brain during bacterial infection in Drosophila

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: 125, P. 280 - 291

Published: Jan. 15, 2025

Language: Английский

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Influence of cell bioenergetics on host-pathogen interaction in the lung

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Pulmonary diseases, arising from infections caused by bacteria, fungi, and viruses, or stemming underlying genetic factors are one of the leading causes mortality in humans, accounting for millions deaths every year. At onset pulmonary crucial roles played phagocytic immune cells, particularly tissue-resident macrophages, regulating response at mucosal barrier. Recent strides have illuminated pivotal role host bioenergetics modulated metabolites derived both pathogens hosts influencing pathophysiology major organs. Their influence extends to processes such as infiltration activation polarization phenomenon. Furthermore, host-derived metabolites, itaconate, contribute promotion anti-inflammatory responses, thereby preventing immunopathology facilitating preservation niches thrive long-term. This review explores recent advancements field immunometabolism, with a particular emphasis on intricacies disease progression bacteria P. aeruginosa, M. tuberculosis S. aureus fungi like C. albicans.

Language: Английский

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Pathogen adaptation to lung metabolites

Current Opinion in Microbiology, Journal Year: 2025, Volume and Issue: 85, P. 102608 - 102608

Published: April 4, 2025

Language: Английский

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Host–microbe interactions in the lung and the role of immunometabolism

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 7 - 26

Published: Jan. 1, 2025

Language: Английский

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A host-pathogen metabolic synchrony that facilitates disease tolerance

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 19, 2025

Disease tolerance mitigates organ damage from non-resolving inflammation during persistent infections, yet its underlying mechanisms remain unclear. Here we show, in a Pseudomonas aeruginosa pneumonia mouse model, that disease depends on the mitochondrial metabolite itaconate, which mediates cooperative host-pathogen interactions. In P. aeruginosa, itaconate modifies key cysteine residues TCA cycle enzymes critical for succinate metabolism, inducing bioenergetic stress and promoting formation biofilms are less immunostimulatory allow bacteria to integrate into local microbiome. Itaconate incorporates central metabolism of biofilm, driving exopolysaccharide production-particularly alginate-which amplifies airway signaling. This itaconate-alginate interplay limits host immunopathology by enabling pulmonary glutamine assimilation, activating glutaminolysis, thereby restrain detrimental caused inflammasome. Clinical sample analysis reveals adapts this metabolic environment through compensatory mutations anti-sigma-factor mucA, restore succinate-driven bioenergetics disrupt synchrony essential sustaining tolerance.

Language: Английский

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Fasting-induced ketogenesis sensitizes bacteria to antibiotic treatment

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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