IL-2, IL-17A and TNF‐α hold potential as biomarkers for predicting acute mountain sickness prior to ascent DOI

Haoran Guo,

Qi Wang, Tao Li

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 181, P. 156694 - 156694

Published: July 18, 2024

Language: Английский

Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation DOI Creative Commons
Giulia Bonavina, Ramanaiah Mamillapalli, Graciela Krikun

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 1, 2024

Human bone marrow-derived stem cells (hBMDSCs) are well characterized mediators of tissue repair and regeneration. An increasing body evidence indicates that these exert their therapeutic effects largely through paracrine actions rather than clonal expansion differentiation. Here we studied the role microRNAs (miRNAs) present in extracellular vesicles (EVs) from hBMDSCs regeneration cell differentiation targeting endometrial stromal fibroblasts (eSF).

Language: Английский

Citations

5
Role of the type 3 cytokines IL-17 and IL-22 in modulating metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Mohamed N. Abdelnabi, Ghada S. Hassan, Naglaa H. Shoukry

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of diseases that span simple steatosis, metabolic steatohepatitis (MASH) and fibrosis may progress to cirrhosis cancer. The pathogenesis MASLD is multifactorial driven by environmental, genetic, immune factors. This review will focus on the role type 3 cytokines IL-17 IL-22 in progression. are produced similar adaptive innate cells such as Th17 lymphoid cells, respectively. IL-17-related signaling upregulated during resulting increased chemokines proinflammatory microenvironment, enhanced recruitment myeloid T leading exacerbation inflammation also act directly activating hepatic stellate fibrosis. In contrast, pleiotropic cytokine with dominantly protective signature currently being tested therapeutic strategy. exhibits beneficial effects abrogates MASH-related development via inducing production anti-oxidants anti-apoptotic A sex-dependent effect has been attributed both cytokines, most importantly or related conditions. Altogether, key effectors We these two produce them MASLD, their interaction host factors driving including sexual dimorphism, potential benefits.

Language: Английский

Citations

5
Regulation of systemic metabolism by tissue-resident immune cell circuits DOI Creative Commons
Joey H. Li, Matthew R. Hepworth, Timothy E. O’Sullivan

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(6), P. 1168 - 1186

Published: June 1, 2023

Recent studies have demonstrated that tissue homeostasis and metabolic function are dependent on distinct tissue-resident immune cells form functional cell circuits with structural cells. Within these circuits, integrate cues from dietary contents commensal microbes in addition to endocrine neuronal signals present the microenvironment regulate metabolism. These can become dysregulated during inflammation overnutrition, contributing diseases. Here, we review evidence describing key cellular networks within between liver, gastrointestinal tract, adipose control systemic metabolism how certain We also identify open questions field potential enhance our understanding of health disease.

Language: Английский

Citations

13
Post-transcriptional checkpoints in autoimmunity DOI
Rami Bechara, Stéphan Vagner, Xavier Mariette

et al.

Nature Reviews Rheumatology, Journal Year: 2023, Volume and Issue: 19(8), P. 486 - 502

Published: June 13, 2023

Language: Английский

Citations

11
Network pharmacology, molecular docking, and experimental verification reveal the mechanism of Yi-Shen-Hua-Shi granules treating acute kidney injury DOI
Sheng Zhang,

Jiankui Du,

Minmin Lu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119320 - 119320

Published: Jan. 1, 2025

Language: Английский

Citations

0
Interleukin-17 and fat: Timing is everything DOI
Matthew C. Sinton,

Olivia Shorthouse,

Alice Costain

et al.

Immunity, Journal Year: 2025, Volume and Issue: 58(1), P. 15 - 17

Published: Jan. 1, 2025

Language: Английский

Citations

0
Understanding the Mechanistic and Therapeutic Perspectives on Cytokines and Chemokines in Acute High-Altitude Illness Syndromes DOI Creative Commons
Amin Ullah, Rajeev K. Singla,

Yingbo Zhang

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101249 - 101249

Published: Feb. 1, 2025

Language: Английский

Citations

0
The repurposing of Nitazoxanide for psoriasis treatment exerts therapeutic effects through skin metabolic reprogramming DOI
Jong Yeong Lee,

Ha Eun Kim,

Seung Taek Lee

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Vitamin D: What role in obesity-related cancer? DOI
Pierrick Martinez, William B. Grant

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Isolation of phytochemicals and exploration the mechanism of Dolichandrone spathacea in the treatment of chronic bronchitis by integrating network pharmacology, molecular docking, and experimental validation DOI
Dang-Khoa Nguyen, Ta-Wei Liu,

Man-Hsiu Chu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract Background Dolichandrone spathacea (D. spathacea) is a common traditional Chinese medicine extensively used to treat chronic bronchitis (CB). However, phytochemicals and potential mechanisms of this species against CB have not been fully illuminated. Therefore, study aimed isolate elucidate the D. spathacea, clarify its molecular key therapeutic targets in treating through network pharmacology validate these findings using docking, experimental approaches. Results Three compounds, beta-sitosterol, 6-O-trans-p-coumaroyl ajugol, 6-O-[(E)-4-methoxycinnamoyl] catalpol were isolated from EtOAc fraction, with beta-sitosterol being reported for first time species. After combining species identified those literature references, 59 compounds obtained, 30 bioactive screened. Among these, luteolin was predicted interact highest number CB-related proteins. Using GeneCards DrugBank databases, 66 intersecting target genes identified between spathacea CB. The protein-protein interaction analysis core targets, including TNF, AKT1, SRC, EGFR, IL2, MMP-9, HSP90AA1, PTGS2. KEGG enrichment analyses suggested that exerts effects on by modulating various biological processes pathways. Notably, top three – PTGS2, MMP-9 enriched TNF IL-17 signaling pathways. computational docking could bind all spathacea. validation revealed ethanol extract inhibited nitric oxide production induced LPS, an IC50 value 25.34 μg/mL. At concentration 100 μg/mL, effectively TNF-α, IL-1β cytokine, inhibition rates 71.67%, 90.22%, respectively. Conclusion This systematically investigated phytoconstituents, genes, treatment bronchitis. It highlights role pathways therapy. suggest exhibits significant anti-inflammatory CB, providing robust scientific evidence novel insights further research

Language: Английский

Citations

0