IL-2, IL-17A and TNF‐α hold potential as biomarkers for predicting acute mountain sickness prior to ascent DOI

Haoran Guo,

Qi Wang, Tao Li

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 181, P. 156694 - 156694

Published: July 18, 2024

Language: Английский

FOSL1 promotes keratinocyte migration and wound repair by modulating the IL17 signaling pathway DOI Creative Commons

Haoran Mao,

Xiao Jiang,

Jiaji Liang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 12, 2025

Language: Английский

Citations

0
Screening of enzymes for bi-functional whey protein hydrolysates: Based on virtual enzymolysis, fragmentomics, and molecular docking in silico DOI

Ruoyun Gao,

Fanhua Kong,

Guangqing Mu

et al.

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116629 - 116629

Published: May 1, 2025

Language: Английский

Citations

0
IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated Metabolic Reprogramming in Psoriasis DOI
Bhavuk Dhamija, Soumitra Marathe, Vinanti Sawant

et al.

The Journal of Immunology, Journal Year: 2023, Volume and Issue: 212(2), P. 302 - 316

Published: Nov. 29, 2023

Abstract Immune cell–derived IL-17A is one of the key pathogenic cytokines in psoriasis, an immunometabolic disorder. Although established regulator cutaneous immune cell biology, its functional and metabolic effects on nonimmune cells skin, particularly keratinocytes, have not been comprehensively explored. Using multiomics profiling systems biology–based approaches, we systematically uncover significant roles for reprogramming human primary keratinocytes (HPKs). High-throughput liquid chromatography–tandem mass spectrometry nuclear magnetic resonance spectroscopy revealed IL-17A–dependent regulation multiple HPK proteins metabolites carbohydrate lipid metabolism. Systems-level MitoCore modeling using flux-balance analysis identified IL-17A–mediated increases glycolysis, glutaminolysis, uptake, which were validated biochemical cell-based assays stable isotope-resolved metabolomics. treatment triggered downstream mitochondrial reactive oxygen species HIF1α expression resultant proliferation, consistent with observed elevation these effectors epidermis patients psoriasis. Pharmacological inhibition or reversed hyperproliferation. These results identify as important target reveal involvement pathways skin.

Language: Английский

Citations

9
A Comprehensive Pilot Study to Elucidate the Distinct Gut Microbial Composition and Its Functional Significance in Cardio-Metabolic Disease DOI

Ashwini Kumar Ray,

Avaneesh Shukla,

Alka Yadav

et al.

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Language: Английский

Citations

3
IL-2, IL-17A and TNF‐α hold potential as biomarkers for predicting acute mountain sickness prior to ascent DOI

Haoran Guo,

Qi Wang, Tao Li

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 181, P. 156694 - 156694

Published: July 18, 2024

Language: Английский

Citations

3