Individual variation in natural or manipulated corticosterone does not covary with circulating glucose in a wild bird

Journal of Experimental Biology, Journal Year: 2022, Volume and Issue: 225(4)

Published: Jan. 24, 2022

Animals respond to sudden challenges with a coordinated set of physiological and behavioral responses that enhance the ability cope stressors. While general characteristics vertebrate stress response are well described, it is not as clear how individual components covary between or within individuals. A rapid increase in glucocorticoids coordinates one primary downstream results an glucose availability via reduced utilization. Here, we asked whether between- within-individual variation corticosterone directly predict glucose. We collected 2673 paired measures from 776 tree swallows (Tachycineta bicolor) four populations spanning species range. In adults, both increased during standardized restraint protocol all populations. Moreover, population experimentally increasing precursor stimulates release resulted further measures. contrast, nestlings did show robust handling manipulation. Despite this group-level variation, there was very little evidence any between-individual predicted regulation. Glucose moderately repeatable individuals, but were unrelated. Our highlight fact strong aspect acute (corticosterone) does necessarily indicate specific components, such glucose, will similarly responses. These have implications for understanding evolution integrated systems.

Language: Английский

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Environmental unpredictability shapes glucocorticoid regulation across populations of tree swallows

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Aug. 13, 2020

Abstract The ability to respond appropriately challenges is an important contributor fitness. Variation in the regulation of glucocorticoid hormones, which mediate phenotypic response challenges, can therefore influence persist a given environment. We compared stress responsiveness four populations tree swallows ( Tachycineta bicolor ) breeding under different environmental conditions evaluate support for selective pressures driving evolution regulation. In accordance with unpredictability hypothesis, stronger responses were seen more unpredictable environments. Contrary reproductive value was not lower engaging valuable attempts. Populations also had negative feedback, supports “mitigating” rather than “magnifying” effect feedback on responses. These results suggest that combining robust strong may be persisting or rapidly changing

Language: Английский

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Do hormone manipulations reduce fitness? A meta-analytic test of the Optimal Endocrine Phenotype Hypothesis

Molecular and Cellular Endocrinology, Journal Year: 2019, Volume and Issue: 500, P. 110640 - 110640

Published: Nov. 9, 2019

Language: Английский

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Information theory in vertebrate stress physiology

Trends in Endocrinology and Metabolism, Journal Year: 2021, Volume and Issue: 33(1), P. 8 - 17

Published: Nov. 5, 2021

Language: Английский

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An evolutionary perspective on stress responses, damage and repair

Hormones and Behavior, Journal Year: 2022, Volume and Issue: 142, P. 105180 - 105180

Published: May 12, 2022

Variation in stress responses has been investigated relation to environmental factors, species ecology, life history and fitness. Moreover, mechanistic studies have unravelled molecular mechanisms of how acute chronic cause physiological impacts ('damage'), this damage can be repaired. However, it is not yet understood the fitness effects repair influence response evolution. Here we study evolution hormone levels as a function stressor occurrence, efficiency repair. We hypothesise that depends on consequences ability damage. To obtain some general insights, model simplified scenario which an organism repeatedly encounters with certain frequency predictability (temporal autocorrelation). The defend itself by mounting (elevated level), but causes takes time identify optimal strategies then investigate those respond exposures stressor. find for higher rates, baseline peak are higher. This typically means experiences damage, afford because repaired more quickly, very high rates does build up. With increasing stressor, sustained longer, animal expects persist, thus builds result (and potentially fatal) when organisms exposed stressors they evolutionarily adapted. Overall, our results highlight at least three factors need considered jointly advance understanding physiology evolved: (i) temporal dynamics occurrence; (ii) relative mortality risk imposed versus caused response; (iii) mechanisms.

Language: Английский

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Coping With Urban Habitats Via Glucocorticoid Regulation: Physiology, Behavior, and Life History in Stream Fishes

Integrative and Comparative Biology, Journal Year: 2022, Volume and Issue: 62(1), P. 90 - 103

Published: Jan. 11, 2022

Abstract As environments become urbanized, tolerant species more prevalent. The physiological, behavioral and life-history mechanisms associated with the success of such in urbanized habitats are not well understood, especially freshwater ecosystems. Here, we examined glucocorticoid (GC) profiles, traits, behavior two fish across a gradient urbanization to understand coping capacity trade-offs. We studied live-bearing Western Mosquitofish (Gambusia affinis) for years slightly less tolerant, egg-laying, Blacktail Shiner (Cyprinella venusta) one year. used water-borne hormone method examine baseline, stress-induced, recovery cortisol release rates six streams differing degrees urbanization. also measured traits related reproduction, G. affinis, shoaling individual activity novel arena. Both showed trend reduced stress responsiveness streams, accompanied by higher reproductive output. Although all populations fit this trend, these results suggest that GC suppression may be adaptive urban habitats. In increased urbanization, individuals lowest response highest had greatest allotment, suggesting rapid return baseline levels is an important mechanism. altered trade-offs whereas did vary systematically Thus, cope anthropogenically modified altering their profiles These contribute understanding driving species-specific adaptations thereby community structure systems land-use converted areas.

Language: Английский

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Best practices for building and curating databases for comparative analyses

Journal of Experimental Biology, Journal Year: 2022, Volume and Issue: 225(Suppl_1)

Published: March 8, 2022

Comparative analyses have a long history of macro-ecological and -evolutionary approaches to understand structure, function, mechanism constraint. As the pace science accelerates, there is ever-increasing access diverse types data open databases that are enabling inspiring new research. Whether conducting species-level trait-based analysis or formal meta-analysis study effect sizes, comparative share common reliance on reliable, carefully curated databases. Unlike many scientific endeavors, building database process researchers undertake infrequently in which we not formally trained. This Commentary provides an introduction for highlights challenges solutions authors this faced their own experiences. We focus four major tips: (1) strategizing literature search; (2) structuring multiple use; (3) establishing version control within (and beyond) your study; (4) importance making accessible. highlight how one's approach these tasks often depends goal nature data. Finally, assert curation single-question has several disadvantages: it limits possibility using purposes decreases efficiency due independent repeatedly sifting through large volumes raw information. argue curating broader than one research question can provide return investment, fields could increase if community was established.

Language: Английский

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Glucocorticoids in a warming world: Do they help birds to cope with high environmental temperatures?

Hormones and Behavior, Journal Year: 2022, Volume and Issue: 142, P. 105178 - 105178

Published: May 10, 2022

Language: Английский

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FKBP5: A Key Mediator of How Vertebrates Flexibly Cope with Adversity

BioScience, Journal Year: 2020, Volume and Issue: 70(12), P. 1127 - 1138

Published: Sept. 1, 2020

Abstract Flexibility in the regulation of hypothalamic–pituitary–adrenal (HPA) axis is an important mediator stress resilience as it helps organisms adjust to, avoid, or compensate for acute and chronic challenges across changing environmental contexts. Glucocorticoids remain favorite metric from medicine to conservation biology attempt quantify despite skepticism around their consistency relation individual health, welfare, fitness. We suggest that a cochaperone molecule related heat shock proteins involved glucocorticoid receptor activity, FKBP5, may mediate HPA flexibility therefore because affects how individuals can regulate glucocorticoids capacitates abilities phenotypes appropriately prevailing, adverse conditions. Although well studied biomedical literature, FKBP5 research wild vertebrates limited. In present article, we highlight potential major role response adversity humans lab rodents.

Language: Английский

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Nesting strategy shapes territorial aggression but not testosterone: A comparative approach in female and male birds

Hormones and Behavior, Journal Year: 2021, Volume and Issue: 133, P. 104995 - 104995

Published: May 14, 2021

Language: Английский

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