Critical Reviews in Therapeutic Drug Carrier Systems,
Journal Year:
2024,
Volume and Issue:
42(2), P. 73 - 106
Published: Nov. 15, 2024
Brain
cancer
continues
to
be
one
of
the
most
formidable
malignancies
manage,
mainly
attributable
presence
blood-brain
barrier
(BBB)
limiting
permeability
drugs
and
diverse
characteristics
brain
tumors
complicating
treatment.
The
management
has
been
hampered
by
many
different
factors,
including
impermeability
BBB,
which
restricts
delivery
chemotherapeutic
agents
tumor
site,
as
well
intertumoral
heterogeneity
influence
stem
cells.
In
addition,
small
molecular
weight
cannot
specifically
accumulate
in
malignant
cells
have
a
limited
circulation
half-life.
Nanoparticles
(NPs)
can
engineered
traverse
BBB
transport
therapeutic
medications
directly
into
brain,
enhancing
their
efficacy
compared
with
conventional
unbound
drugs.
Surface
modifications
NPs
boost
efficiency
increasing
selectivity
towards
receptors.
This
review
covers
treatment
methods
for
gliomas,
associated
risk
improvements
drug
administration,
emphasizing
future
potential
polymeric
mechanism
crossing
BBB.
To
surmount
these
obstacles,
newly
formulated
drug-delivery
approach
utilizing
NPs,
particularly
those
coated
cell
membranes,
demonstrated
treating
cancer.
These
provide
targeted
specificity,
biocompatibility,
extended
circulation,
enhanced
penetration,
immune
evasion.
focuses
on
coating
strategies
PLGA
dual-targeting
methods,
enhance
tumor-targeted
Polymers,
Journal Year:
2024,
Volume and Issue:
16(2), P. 206 - 206
Published: Jan. 10, 2024
Degradable
polymers
(both
biomacromolecules
and
several
synthetic
polymers)
for
biomedical
applications
have
been
promising
very
much
in
the
recent
past
due
to
their
low
cost,
biocompatibility,
flexibility,
minimal
side
effects.
Here,
we
present
an
overview
with
updated
information
on
natural
degradable
where
a
brief
account
different
polysaccharides,
proteins,
viz.
polyesters/polyamino
acids/polyanhydrides/polyphosphazenes/polyurethanes
relevant
has
provided.
The
various
approaches
transformation
of
these
by
physical/chemical
means
cross-linking,
as
polyblends,
nanocomposites/hybrid
composites,
interpenetrating
complexes,
interpolymer/polyion
functionalization,
polymer
conjugates,
block
graft
copolymers,
are
described.
degradation
mechanism,
drug
loading
profiles,
toxicological
aspects
polymeric
nanoparticles
formed
also
defined.
Biomedical
polymer-based
biomaterials
wound
dressing/healing,
biosensors,
delivery
systems,
tissue
engineering,
regenerative
medicine,
etc.,
highlighted.
In
addition,
use
such
nano
systems
solve
current
problems
is
briefly
reviewed.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
352, P. 122899 - 122899
Published: July 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 1469 - 1495
Published: May 1, 2024
This
manuscript
offers
a
comprehensive
overview
of
nanotechnology's
impact
on
the
solubility
and
bioavailability
poorly
soluble
drugs,
with
focus
BCS
Class
II
IV
drugs.
We
explore
various
nanoscale
drug
delivery
systems
(NDDSs),
including
lipid-based,
polymer-based,
nanoemulsions,
nanogels,
inorganic
carriers.
These
offer
improved
efficacy,
targeting,
reduced
side
effects.
Emphasizing
crucial
role
nanoparticle
size
surface
modifications,
review
discusses
advancements
in
NDDSs
for
enhanced
therapeutic
outcomes.
Challenges
such
as
production
cost
safety
are
acknowledged,
yet
potential
transforming
methods
is
highlighted.
contribution
underscores
importance
nanotechnology
pharmaceutical
engineering,
suggesting
it
significant
advancement
medical
applications
patient
care.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5842 - 5842
Published: May 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 7547 - 7566
Published: July 1, 2024
Abstract:
Cancer
poses
a
significant
threat
to
human
life
and
health.
Chemotherapy
is
currently
one
of
the
effective
cancer
treatments,
but
many
chemotherapy
drugs
have
cell
toxicity,
low
solubility,
poor
stability,
narrow
therapeutic
window,
unfavorable
pharmacokinetic
properties.
To
solve
above
problems,
target
drug
delivery
tumor
cells,
reduce
side
effects
drugs,
an
anti-tumor
system
based
on
microenvironment
has
become
focus
research
in
recent
years.
The
construction
reduction-sensitive
nanomedicine
disulfide
bonds
attracted
much
attention.
Disulfide
good
reductive
responsiveness
can
effectively
high
glutathione
(GSH)
levels
environment,
enabling
precise
delivery.
further
enhance
targeting
accelerate
release,
are
often
combined
with
pH-responsive
nanocarriers
highly
expressed
ligands
cells
construct
systems.
connect
molecules
polymer
system,
as
well
between
different
carrier
molecules.
This
article
summarized
systems
(DDS)
that
researchers
constructed
years
bond
microenvironment,
cleavage-triggering
conditions,
various
loading
strategies,
design.
In
this
review,
we
also
discuss
controlled
release
mechanisms
these
DDS
clinical
applicability
challenges
faced
translation.
Keywords:
bond,
systems,
GSH/ROS
Polymers,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1182 - 1182
Published: April 23, 2024
Polymers
derived
from
natural
biomass
have
emerged
as
a
valuable
resource
in
the
field
of
biomedicine
due
to
their
versatility.
Polysaccharides,
peptides,
proteins,
and
lignin
demonstrated
promising
results
various
applications,
including
drug
delivery
design.
However,
several
challenges
need
be
addressed
realize
full
potential
these
polymers.
The
current
paper
provides
comprehensive
overview
latest
research
perspectives
this
area,
with
particular
focus
on
developing
effective
methods
efficient
systems.
This
review
aims
offer
insights
into
opportunities
associated
use
polymers
provide
roadmap
for
future
field.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(8), P. 960 - 960
Published: Aug. 7, 2024
Cardiovascular
diseases
(CVDs)
are
one
of
the
leading
causes
death
worldwide.
Despite
significant
advances
in
current
drug
therapies,
issues
such
as
poor
targeting
and
severe
side
effects
persist.
In
recent
years,
nanomedicine
has
been
extensively
applied
research
treatment
CVDs.
Among
these,
biomembrane-modified
biomimetic
nanodrug
delivery
systems
(BNDSs)
have
emerged
a
focus
due
to
their
unique
biocompatibility
efficient
capabilities.
By
modifying
with
biological
membranes,
BNDSs
can
effectively
reduce
recognition
clearance
by
immune
system,
enhance
circulation
time
vivo,
improve
targeting.
This
review
first
provides
an
overview
classification
pathological
mechanisms
CVDs,
then
systematically
summarizes
progress
discussing
design
principles,
functional
characteristics,
clinical
application
potential.
Finally,
it
highlights
challenges
faced
translation
BNDSs.
