Phytochemical analysis and biological study on Sinapis alba L. seeds extract incorporated with metal nanoparticles, in vitro approach DOI Creative Commons
Wael M. Aboulthana, Amal M. El‐Feky, Noha E. Ibrahim

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 21, 2025

Abstract White mustard ( Sinapis alba L.) seeds are the most commonly used species in herbal medicine to treat a wide range of inflammatory disorders. Due its increased bioavailability and lower toxicity, green biosynthesis metal nanoparticles (M-NPs) utilizing plant extract as capping agent has been demonstrated over number years. Thus, current study sought examine vitro biological activity copper oxide (CuO-NPs) selenium (Se-NPs) that were biosynthesized using aqueous, methanolic, petroleum ether extracts from S. seeds. Phytochemical activities (antioxidant, scavenging, anti-diabetic, anti-acetylcholinesterase, anti-arthritic, anti-inflammatory, cytotoxic activities) assayed all prepared before after being for M-NPs. It was found total methanolic possessed highest compared other native extracts. The LC-ESI-MS/MS analysis secondary metabolites showed contained 7 phenolic acids 9 flavonoid aglycones. This helped find active ingredients. We characterized 8 acid derivatives, glycosides, 4 aliphatic glucosinolates, 3 aromatic aryl glucosinolates aqueous extract. Furthermore, contains concentrations polyphenols, condensed tannins, compounds. Se-NPs higher those CuO-NPs. median lethal dose (LD 50 ) studied appeared safer findings this concluded is suitable bioresource biosynthesizing through nanotechnology, with efficiency relation metabolite fingerprint.

Language: Английский

Crossing the blood–brain barrier: emerging therapeutic strategies for neurological disease DOI

Josephine H Pedder,

Adam M. Sonabend,

Michael D Cearns

et al.

The Lancet Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

3
Assessment of the In Vitro Biological Activities of Schiff Base-Synthesized Copper Oxide Nanoparticles as an Anti-Diabetic, Anti-Alzheimer, and Anti-Cancer Agent DOI Creative Commons
Abdulrahman A. Almehizia, Ahmed M. Naglah,

Sadeem S. Aljafen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 180 - 180

Published: Feb. 1, 2025

Background/Objectives: Numerous diseases such as diabetes, Alzheimer’s disease, and cancer have spread in the whole world, especially Arab world. Also, various applications of Schiff-base functionalized nanoparticles copper oxide (CuO-NPs) therapeutic been discovered. Thus, current research highlights (i) synthesis produced with a Schiff base (SB) serving capping agent during their (ii) assessment vitro biological activities base-synthesized (SB-CuO-NPs) (SB). Methods: SB-CuO-NPs were characterized using ultraviolet-visible (UV-Vis) spectroscopy, zeta potential, DLS analysis, transmission electron microscope (TEM). It also focuses on assessing activities, including antioxidant, scavenging, anti-diabetic, anti-Alzheimer, anti-arthritic, anti-inflammatory, cytotoxic enzymes inhibitory methods described literature. Results: The results compared those SB. demonstrated superior when to SB from which they produced. Conclusions: this investigation concluded that CuO-NPs, synthesized an alternative agent, exhibited enhanced efficacy relative original In future, efficiency against Alzheimer’s, will be assessed experimental animals (in vivo).

Language: Английский

Citations

2
Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer’s disease DOI Creative Commons

Léa Otaegui,

Théo Urgin,

Taghrid Zaiter

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125125 - 125125

Published: Jan. 8, 2025

Reduced docosahexaenoic acid (DHA) concentrations seem to be associated with an increased risk of Alzheimer's disease (AD), and DHA accretion the brain across blood-brain-barrier (BBB) can modulated by various factors. Therefore, there is urgent need identify efficient non-invasive method ensure enrichment. In present study, a safe stable DHA-enriched nanoemulsion, designed protect against oxidation, was administered intranasally in transgenic mouse model AD, J20 mice. Intranasal treatment nanoformulated significantly improved well-being working spatial memory six-months-old These behavioral effects were reduction amyloid deposition, oxidative stress, neuroinflammation tissues, which may partially due DHA-induced inactivation pleiotropic kinase GSK3β. conclusion, intranasal administration exhibited strong therapeutic disease-modifying benefits AD model. Given that has already shown safety tolerability healthy human subjects, our results further support for clinical trials assess potential this approach patients.

Language: Английский

Citations

1
Natural compounds as modulators of miRNAs: a new frontier in bladder cancer treatment DOI
Ahmed I. Abulsoud, Shaza H. Aly,

Sherif S. Abdel Mageed

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(3)

Published: Jan. 30, 2025

Language: Английский

Citations

1
Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery DOI
Mingzhu Xie, Jing Zhao, Xikang Feng

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140934 - 140934

Published: Feb. 11, 2025

Language: Английский

Citations

1
Investigating the binding interactions of cetirizine and diphenhydramine in SDS-SDBS mixed micelles DOI
Anirudh Srivastava, S. C. Tiwari, Javed Masood Khan

et al.

Colloid & Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

1
Advances in bio-polymer coatings for probiotic microencapsulation: chitosan and beyond for enhanced stability and controlled release DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe,

Nawar. F. Razooqi

et al.

Designed Monomers & Polymers, Journal Year: 2024, Volume and Issue: 28(1), P. 1 - 34

Published: Dec. 31, 2024

This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.

Language: Английский

Citations

5
Exploring the antibacterial, antifungal and anticancer effects of a novel bacteriocin-cerium oxide nanoconjugate DOI

Sana M.H. Al-Shimmary,

Zina Hashem Shehab, Emad Hamdi Jassim

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: 174, P. 113925 - 113925

Published: Jan. 8, 2025

Language: Английский

Citations

0
Exploring nanocomposite materials in clinical dermatology: Innovations for treating skin diseases DOI Creative Commons
Sandipan Dasgupta, Subhasundar Maji, Sanjay Dey

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 7, P. 100139 - 100139

Published: Jan. 1, 2025

Language: Английский

Citations

0
In vivo toxicity of chitosan-based nanoparticles: a systematic review DOI Creative Commons

Shela Salsabila,

Miski Aghnia Khairinisa, Nasrul Wathoni

et al.

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2025, Volume and Issue: 53(1), P. 1 - 15

Published: Feb. 9, 2025

Chitosan nanoparticles have been extensively utilised as polymeric drug carriers in formulations due to their potential enhance delivery, efficacy, and safety. Numerous toxicity studies previously conducted assess the safety profile of chitosan-based nanoparticles. These employed various methodologies, including test animals, interventions, different routes administration. This review aims summarise research on with a focus general tests determine LD50 NOAEL values. It can serve repository reference for nanoparticles, facilitating future further development drugs delivery system using chitosan Publications from 2014 2024 were obtained PubMed, Scopus, Google Scholar, ScienceDirect, accordance inclusion exclusion criteria.The ARRIVE 2.0 guidelines evaluate quality risk-of-bias vivo studies. The results demonstrated favourable profiles, often exhibiting reduced compared free or substances. Acute consistently reported high values, frequently exceeding 5000 mg/kg body weight, while subacute typically revealed no significant adverse effects. Various administration varied, oral, intravenous, intraperitoneal, inhalation, topical, each demonstrating promising profiles.

Language: Английский

Citations

0