AI-based fully automatic analysis of retinal vascular morphology in pediatric high myopia

BMC Ophthalmology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 27, 2024

Language: Английский

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Investigating bevacizumab and its fragments sustained release from intravitreal administrated PLGA Microspheres: A modeling approach

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2023, Volume and Issue: 193, P. 285 - 293

Published: Nov. 18, 2023

Intravitreal administrated bevacizumab has emerged as an effective antibody for suppressing VEGF expression in age-related macular degeneration (AMD) therapy. This study discusses certain issues related to the sustained release of from intravitreal poly(lactic-co-glycolic acid) (PLGA) microspheres. A computational model elucidating ocular kinetics is demonstrated, wherein drug PLGA microspheres modeled using Koizumi approach, complemented by empirical that links a size-dependent hydrolytic degradation drug-loaded polymeric microparticles. The results simulation were then rigorously validated against experimental data. as-developed proved remarkably accurate predicting time-concentration profiles obtained following injection significantly different sizes. Notably, distinct tissues almost unaffected size intravitreally administered Furthermore, successfully predicted retinal concentration and its fragments (e.g., ranibizumab) form solution. As such, this transport holds tremendous potential facilitating reliable evaluation planned anti-VEGF therapies.

Language: Английский

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The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye

International Journal for Numerical Methods in Biomedical Engineering, Journal Year: 2023, Volume and Issue: 40(2)

Published: Nov. 22, 2023

Abstract We present our continuous efforts from a modeling and numerical viewpoint to develop powerful flexible mathematical computational framework called Ocular Mathematical Virtual Simulator (OMVS). The OMVS aims solve problems arising in biomechanics hemodynamics within the human eye. discuss contribution towards improving reliability reproducibility of studies by performing thorough validation predictions against experimental data. proved capable simulating complex multiphysics multiscale scenarios motivated study glaucoma. Furthermore, its modular design allows integration new models methods as research moves forward, supports utilization promising non‐invasive clinical investigation tool for personalized ophthalmology.

Language: Английский

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Linking Vascular Structure and Function: Image-Based Virtual Populations of the Retina

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(4), P. 40 - 40

Published: April 29, 2024

This study explored the relationship among microvascular parameters as delineated by optical coherence tomography angiography (OCTA) and retinal perfusion. Here, we introduce a versatile framework to examine interplay between vascular structure function generating virtual vasculatures from central vessels macular capillaries. Also, have developed hemodynamics model that evaluates associations morphology

Language: Английский

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Analysis of Waveform Parameters in the Retinal Vasculature via Mathematical Modeling and Data Analytics Methods

La Matematica, Journal Year: 2024, Volume and Issue: 3(4), P. 1297 - 1319

Published: Sept. 11, 2024

Language: Английский

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