Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese DOI Creative Commons

Zhuqin Gu,

Binbin Wang, Yong‐Biao Zhang

et al.

Scientific Reports, Journal Year: 2015, Volume and Issue: 5(1)

Published: Oct. 28, 2015

Abstract Circadian disruptions may result in sleep problems, oxidative stress and an altered inflammatory response. These symptoms contribute to PD pathogenesis, despite a lack of direct experimental evidence supporting this relationship. Clock genes are essential drive maintain circadian rhythm. To elucidate the possible role PD, we investigated 132 tag variants eight clock genes. We genotyped these tags within 1,394 Chinese cases 1,342 controls using Illumina GoldenGate chips. discovered that SNPs ARNTL (rs900147, P = 3.33 × 10 −5 , OR 0.80) PER1 (rs2253820, 5.30 −6 1.31) significantly associated with risk. Moreover, positive association rs900147 variant was more robust tremor dominant (TD) ( 3.44 −4 ) than postural instability gait difficulty (PIGD) 6.06 −2 ). The rs2253820 PIGD 5.42 TD 4.2 Haplotype analysis also showed were PD. Imputation identified some which affect gene expression through altering transcription factor binding site. In summary, our findings suggest genetic polymorphisms genes, as well disruptions, pathogenesis.

Language: Английский

Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges DOI
Dimitrios Tsikas

Analytical Biochemistry, Journal Year: 2016, Volume and Issue: 524, P. 13 - 30

Published: Oct. 24, 2016

Language: Английский

Citations

1638
The Redox Code DOI Open Access
Dean P. Jones, Helmut Sies

Antioxidants and Redox Signaling, Journal Year: 2015, Volume and Issue: 23(9), P. 734 - 746

Published: April 19, 2015

Significance: The redox code is a set of principles that defines the positioning nicotinamide adenine dinucleotide (NAD, NADP) and thiol/disulfide other systems as well thiol proteome in space time biological systems. richly elaborated an oxygen-dependent life, where activation/deactivation cycles involving O2 H2O2 contribute to spatiotemporal organization for differentiation, development, adaptation environment. Disruption this organizational structure during oxidative stress represents fundamental mechanism system failure disease. Recent Advances: Methodology assessing components under physiological conditions has progressed, permitting insight into allowing identification partners proteomics metabolomics. Critical Issues: Complexity networks regulation being revealed step by step, yet much still needs be learned. Future Directions: Detailed knowledge molecular patterns generated from defined or pathological cells organs will understanding component health Ultimately, there scientific basis modern medicine. Antioxid. Redox Signal. 23, 734–746.

Language: Английский

Citations

541
Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment DOI Creative Commons

Gabriele Sulli,

Michael T. Lam, Satchidananda Panda

et al.

Trends in cancer, Journal Year: 2019, Volume and Issue: 5(8), P. 475 - 494

Published: Aug. 1, 2019

Language: Английский

Citations

366
Oxidative stress: Normal pregnancy versus preeclampsia DOI Creative Commons
Delia I. Chiarello, Cilia Abad,

Deliana Rojas

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2018, Volume and Issue: 1866(2), P. 165354 - 165354

Published: Dec. 24, 2018

Language: Английский

Citations

296
ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications DOI
Nurbubu T. Moldogazieva, Innokenty M. Mokhosoev, N.B. Feldman

et al.

Free Radical Research, Journal Year: 2018, Volume and Issue: 52(5), P. 507 - 543

Published: March 28, 2018

Over the last decade, a dual character of cell response to oxidative stress, eustress versus distress, has become increasingly recognized. A growing body evidence indicates that under physiological conditions, low concentrations reactive oxygen and nitrogen species (RONS) maintained by activity endogenous antioxidant system (AOS) allow reversible oxidative/nitrosative modifications key redox-sensitive residues in regulatory proteins. The reversibility redox such as Cys S-sulphenylation/S-glutathionylation/S-nitrosylation/S-persulphidation disulphide bond formation, or Tyr nitration, which occur through electrophilic attack RONS nucleophilic groups amino acid provides switches activities signalling Key requirement for involvement including ROS-MAPK, ROS-PI3K/Akt, RNS-TNF-α/NF-kB is their specificity provided residue microenvironment reaction kinetics. Glutathione, glutathione peroxidases, peroxiredoxins, thioredoxin, reductases, glutaredoxins modulate level signalling, while some modulators (glutathione, peroxidases peroxiredoxins) are themselves targets modifications. Additionally, gene expression, transcription factors, epigenetic pathways also regulation. present review focuses on sources (NADPH-oxidases, mitochondrial electron-transportation chain (ETC), nitric oxide synthase (NOS), etc.), cross-talks, influence proteins phenomenon attained living cells during evolution control oxygen-enriched environment. We discussed recent advances investigation mechanisms protein adaptive MAPK/PI3K/PTEN, Nrf2/Keap1, NF-κB/IκB, powerful regulators numerous processes, implicated various diseases.

Language: Английский

Citations

247
Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases DOI Creative Commons
Marília Brito Gomes, Carlos Antônio Negrato

Diabetology & Metabolic Syndrome, Journal Year: 2014, Volume and Issue: 6(1)

Published: July 28, 2014

Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria’s oxidative metabolism. It believed alpha-lipoic or its reduced form, dihydrolipoic have many biochemical functions acting as biological antioxidants, metal chelators, reducers oxidized forms other antioxidant agents such vitamin C and E, modulator signaling transduction several pathways. These above-mentioned actions been shown experimental studies emphasizing use potential therapeutic agent chronic diseases with great epidemiological well economic social impact brain cognitive dysfunctions like Alzheimer disease, obesity, nonalcoholic fatty liver burning mouth syndrome, cardiovascular hypertension, some types cancer, glaucoma osteoporosis. Many conflicting data found concerning clinical treatment diabetes diabetes-related complications retinopathy, nephropathy, neuropathy, wound healing diabetic autonomic neuropathy. The most frequent condition which has studied was management peripheral neuropathy patients type 1 2 diabetes. Considering stress, imbalance between pro antioxidants excessive production reactive oxygen species, factor development acid, natural thiol antioxidant, to beneficial effects on stress parameters various tissues we wrote this article order make an up-to-date review current thinking regarding drug therapy myriad could benefits from use.

Language: Английский

Citations

241
The hallmarks of fibroblast ageing DOI
Julia Tigges, Jean Krutmann, Ellen Fritsche

et al.

Mechanisms of Ageing and Development, Journal Year: 2014, Volume and Issue: 138, P. 26 - 44

Published: March 29, 2014

Language: Английский

Citations

225
The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk DOI Open Access

Thomas Münzel,

Mette Sørensen, Frank P. Schmidt

et al.

Antioxidants and Redox Signaling, Journal Year: 2018, Volume and Issue: 28(9), P. 873 - 908

Published: Jan. 19, 2018

Epidemiological studies have provided evidence that traffic noise exposure is linked to cardiovascular diseases such as arterial hypertension, myocardial infarction, and stroke. Noise a nonspecific stressor activates the autonomous nervous system endocrine signaling. According reaction model introduced by Babisch colleagues, chronic low levels of can cause so-called nonauditory effects, disturbances activity, sleep, communication, which trigger number emotional responses, including annoyance subsequent stress. Chronic stress in turn associated with risk factors, comprising increased blood pressure dyslipidemia, viscosity glucose, activation clotting animal models humans. Persistent increases cardiometabolic diseases, coronary artery disease, diabetes mellitus type 2, Recently, we demonstrated aircraft during nighttime induce endothelial dysfunction healthy subjects even more pronounced disease patients. Importantly, impaired function was ameliorated acute oral treatment antioxidant vitamin C, suggesting excessive production reactive oxygen species contributes this phenomenon. More recently, novel characterizing underlying molecular mechanisms leading noise-dependent adverse oxidative stress-related effects on vasculature. With present review, want provide an overview epidemiological, translational clinical, preclinical research addressing nonauditory, focus Antioxid. Redox Signal. 28, 873–908. I. Introduction A. global burden B. Historical view research: concept C. Impact environmental healthcare systems II. Epidemiology: Traffic Cardiometabolic Disease Cardiovascular Metabolic Cancer D. Effects sleep: short dysfunction, E. exposure, annoyance, sensitivity, mental F. air pollution coexposure G. Health children H. mitigation strategies III. Vascular Function Oxidative Stress Prognostic meaning vascular humans animals 1. Direct pathway via ≥100 dB(A) inner ear (hearing loss) 2. Indirect, ≤100 3. ≤85 4. gene regulation established next-generation sequencing 5. Summary conclusions mice IV. Adverse Simultaneous Air Pollution Exposure share similar pathophysiological pathways Gaps current knowledge concerning V. Other Environmental Risk Factors, Stress, (PM/carbon black) stressors VI. Future Perspectives

Language: Английский

Citations

210
Adverse Cardiovascular Effects of Traffic Noise with a Focus on Nighttime Noise and the New WHO Noise Guidelines DOI Creative Commons

Thomas Münzel,

Swenja Kröller‐Schön, Matthias Oelze

et al.

Annual Review of Public Health, Journal Year: 2020, Volume and Issue: 41(1), P. 309 - 328

Published: Jan. 10, 2020

Exposure to traffic noise is associated with stress and sleep disturbances. The World Health Organization (WHO) recently concluded that road increases the risk for ischemic heart disease potentially other cardiometabolic diseases, including stroke, obesity, diabetes. WHO report focused on whole-day exposure, but new epidemiological translational field studies indicate nighttime noise, in particular,is an important factor cardiovascular (CVD) through increased levels of hormones vascular oxidative stress, leading endothelial dysfunction subsequent development various CVDs. Novel experimental found be stress–induced brain damage, mediated by activation NADPH oxidase, uncoupling neuronal nitric oxide synthase, vascular/brain infiltration inflammatory cells. Noise-induced pathophysiology was more pronounced response as compared daytime noise. This review focuses consequences

Language: Английский

Citations

164
The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases DOI Creative Commons
Xueyan Zhang, Yihan Yu,

Hanyu Lei

et al.

Cardiology Research and Practice, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 9

Published: Jan. 30, 2020

Cardiovascular disease, which can lead to angina and shortness of breath, remains one the most serious threats human health. Owing its imperceptible symptoms, it is difficult determine pathogenesis treatment methods for cardiovascular disease. Nuclear factor erythropoietin-2-related 2/heme oxygenase 1 (Nrf2/HO-1) a protein found in all cells body. It activated, transferred nucleus, bound DNA by antioxidant response elements (AREs). As regulator system, upregulates expression HO-1 reduce oxidative stress. Nrf2/HO-1 also has ability modulate calcium levels prevent ferroptosis, pyroptosis, autophagy, programmed cell necrosis, alkaliptosis, clockophagy. In view importance regulation homeostasis, this review summarizes current research on relationship between disease Nrf2/HO-1. Normal diseases, such as viral myocarditis myocardial ischemia-reperfusion injury, have been treated with Rheumatic heart cardiac tumors, arteriosclerosis, arrhythmia, hypertensive infarction during experiments. Research demonstrated clinical application pediatric disease; further trials will help elucidate potential signaling axis.

Language: Английский

Citations

140