Ferroptosis in immunostimulation and immunosuppression

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 199 - 210

Published: July 9, 2023

Summary Ferroptosis is a form of iron‐dependent regulated cell death characterized by the accumulation toxic lipid peroxides, particularly in plasma membrane, leading to lytic death. While it plays crucial role maintaining overall health and proper functioning multicellular organisms, can also contribute tissue damage pathological conditions. Although ferroptotic generally recognized as an immunostimulatory process associated with release damage‐associated molecular patterns (DAMPs), occurrence ferroptosis immune cells or immunosuppressive molecules result tolerance. Consequently, there ongoing exploration targeting upstream signals machinery therapeutically enhance inhibit response. In addition introducing core mechanisms ferroptosis, we will focus on characteristics conditions, context infection, sterile inflammation, tumor immunity.

Language: Английский

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Iron toxicity, ferroptosis and microbiota in Parkinson’s disease: Implications for novel targets

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 105 - 132

Published: Jan. 1, 2024

Language: Английский

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Targeting ferroptosis: a new therapeutic opportunity for kidney diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 3, 2024

Ferroptosis is a form of non-apoptotic regulated cell death (RCD) that depends on iron and characterized by the accumulation lipid peroxides to lethal levels. involves multiple pathways including redox balance, regulation, mitochondrial function, amino acid, lipid, glycometabolism. Furthermore, various disease-related signaling also play role in regulating process oxidation. In recent years, with emergence concept ferroptosis in-depth study its mechanisms, closely associated biological conditions related kidney diseases, organ development, aging, immunity, cancer. This article reviews development ferroptosis, mechanisms (including GSH-GPX4, FSP1-CoQ1, DHODH-CoQ10, GCH1-BH4, MBOAT1/2 pathways), latest research progress involvement diseases. It summarizes diseases within frameworks metabolism, reactive oxygen biology, biology. The introduces key regulatory factors as well important concepts major open questions natural compounds. hoped future research, further breakthroughs can be made understanding regulation mechanism utilizing promote treatments for such acute injury(AKI), chronic disease (CKD), diabetic nephropathy(DN), renal carcinoma. paves way new approach prevent, treat clinical

Language: Английский

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A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease: new insights into emerging mechanisms and therapeutic targets

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 8, 2024

Neurodegenerative diseases represent a pressing global health challenge, and the identification of novel mechanisms underlying their pathogenesis is utmost importance. Ferroptosis, non-apoptotic form regulated cell death characterized by iron-dependent lipid peroxidation, has emerged as pivotal player in neurodegenerative diseases. This review delves into discovery ferroptosis, critical players involved, intricate role neurodegeneration, with an emphasis on Alzheimer’s Parkinson’s We critically appraise unsolved mechanistic links involved initiation propagation such signaling cascade resulting de-repression lipoxygenase translation played mitochondrial voltage-dependent anionic channels iron homeostasis. Particular attention given to dual heme oxygenase which may be linked non-specific activity P450 reductase endoplasmic reticulum. Despite limited knowledge ferroptosis progression Nrf2/Bach1 target genes have crucial defenders anti-ferroptotic pathways. The activation Nrf2 inhibition Bach1 can counteract present promising avenue for future therapeutic interventions targeting

Language: Английский

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Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Amino Acids, Journal Year: 2024, Volume and Issue: 56(1)

Published: May 21, 2024

Abstract In the initial stages of Alopecia Areata (AA), predominance hair breakage or exclamation mark hairs serves as vital indicators disease activity. These signs are non-invasive and commonly employed in dermatoscopic examinations. Despite their clinical salience, underlying etiology precipitating this remains largely uncharted territory. Our exhaustive review existing literature points to a pivotal role for cysteine—a key amino acid central growth—in these mechanisms. This will probe deliberate upon implications aberrant cysteine metabolism pathogenesis AA. It examine potential intersections with autophagy, ferroptosis, immunity, psychiatric manifestations associated Such exploration could illuminate new facets disease's pathophysiology, potentially paving way innovative therapeutic strategies.

Language: Английский

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Nanomedicines Targeting Ferroptosis to Treat Stress-Related Diseases

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8189 - 8210

Published: Aug. 1, 2024

Ferroptosis, a unique form of regulated cell death driven by iron-dependent lethal lipid peroxidation, is implicated in various stress-related diseases like neurodegeneration, vasculopathy, and metabolic disturbance. Stress-related encompass widespread medical disorders that are influenced or exacerbated stress. These stressors can manifest organ tissue systems have significant implications for human overall health. Understanding ferroptosis these offers insights therapeutic strategies targeting relevant pathways. This review explores mechanisms, its role pathophysiology, connection to diseases, the potential ferroptosis-targeted nanomedicines treating conditions. monograph also delves into engineering tackling including cancer, cardia-cerebrovascular, neurodegenerative, inflammatory diseases. Anyhow, nanotherapy holds promise both promoting suppressing managing

Language: Английский

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Tongqiao Huoxue Decoction inhibits ferroptosis by facilitating ACSL4 ubiquitination degradation for neuroprotection against cerebral ischemia-reperfusion injury

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155701 - 155701

Published: May 1, 2024

Language: Английский

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Assessment of the Ferroptosis Regulators: Glutathione Peroxidase 4, Acyl-Coenzyme A Synthetase Long-Chain Family Member 4, and Transferrin Receptor 1 in Patient-Derived Endometriosis Tissue

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 876 - 876

Published: July 21, 2024

Ferroptosis, an iron-dependent form of non-apoptotic cell death, plays a pivotal role in various diseases and is gaining considerable attention the realm endometriosis. Considering classical pathomechanism theories, we hypothesized that ferroptosis, potentially driven by increased iron content at ectopic sites, may contribute to progression This retrospective case-control study provides comprehensive immunohistochemical assessment expression tissue distribution established ferroptosis markers: GPX4, ACSL4, TfR1 endometriosis patients. The case group consisted 38 women with laparoscopically histologically confirmed control 18 other gynecological conditions. Our revealed significant downregulation GPX4 stromal cells patients (

Language: Английский

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Pharmacologically Targeting Ferroptosis and Cuproptosis in Neuroblastoma

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

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Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]‐humanin‐mediated attenuation of oxidative stress and ferroptosis

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Background Oligoasthenozoospermia is a common cause of male infertility, for which effective treatments are urgently needed. Humanin (HN) peptide associated with this condition. Objectives To investigate the ameliorative effect [Gly14]‐Humanin (HNG) on oligoasthenozoospermia and mechanisms. Materials methods Mice were treated cyclophosphamide (CP) to construct mice model oligoasthenozoospermia. The resulting saline or HNG. Subsequently, testis weights, organ indices, testicular structure, sperm counts motilities, litter sizes, serum testosterone concentrations determined. Differential gene expression in tissues was determined by RNA sequencing. TM3, TM4, GC1, GC2 cells exposed erastin induce ferroptosis, followed treatment HNG + ML385 (a nuclear factor erythroid 2‐related 2 inhibitor). Levels reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), ferrous ions (Fe 2+ ) their ferroptosis‐related proteins immunofluorescence western blot. Results improved parameters increased size mice. Kyoto Encyclopaedia Genes Genomes pathway enrichment analysis revealed significant differential genes. after treatment. ROS, MDA, Fe decreased GSH TM3 TM4 In vitro experiments confirmed that activated 2/glutathione peroxidase 4 (Nrf2/GPX4) pathway. However, these effects blocked Discussion conclusion demonstrated therapeutic mouse reducing oxidative stress ferroptosis. cells, attenuated cellular inhibited ferroptosis via Nrf2/GPX4

Language: Английский

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