The Role of Melatonin in the Inflammatory Process in Patients with Hyperglycemia and Leishmania Infection DOI Creative Commons

Thalissa Mariana de Moraes Martins,

Felipe Rubin Ferrari,

Adriele Ataídes de Queiroz

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 950 - 950

Published: Aug. 6, 2024

Type 2 diabetes mellitus is a metabolic disorder that causes chronic high blood sugar levels, and diabetic patients are more susceptible to infections. American cutaneous leishmaniasis an infectious disease caused by parasite affects the skin mucous membranes, leading one or multiple ulcerative lesions. Chronic inflammation functional changes in various organs systems, including immune system, primary of both diseases. Melatonin, essential immunomodulatory, antioxidant, neuroprotective agent, can benefit many immunological processes diseases, leishmaniasis. Although, limited reports available on with The literature suggests melatonin may play promising role inflammatory disorders. This study was designed assess levels mediators affected Blood samples from 25 individuals were analyzed divided into four groups: control group (without any diseases), Leishmania-positive group, type mellitus, combination measured serum through ELISA, while IL-4 TNF-α using flow cytometry, C-reactive protein turbidimetry. found significantly increased decreased levels. However, showed higher than group. These observations suggest influence production leishmaniasis, potentially contributing characteristics

Language: Английский

Dual sources of melatonin and evidence for different primary functions DOI Creative Commons
Russel J. Reıter, Ramaswamy Sharma, Dun‐Xian Tan

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 14, 2024

This article discusses data showing that mammals, including humans, have two sources of melatonin exhibit different functions. The best-known source melatonin, herein referred to as Source #1, is the pineal gland. In this organ, production circadian with maximal synthesis and release into blood cerebrospinal fluid occurring during night. Of total amount produced in we speculate less than 5% synthesized by rhythm has primary function influencing clock at level suprachiasmatic nucleus (the CSF melatonin) clockwork all peripheral organs via receptor-mediated actions. A second (Source # 2) from multiple tissues throughout body, probably being mitochondria these cells. constitutes bulk mammals concerned metabolic regulation. review emphasizes action determining re-dox homeostasis, but it other critical effects well. Extrapineal does not a released acts locally its cell origin possibly paracrine matter on adjacent factors control/influence extrapineal sites are unknown. We propose concentration cells determined subcellular redox state may be inducible under stressful conditions plant

Language: Английский

Citations

24
The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies DOI Creative Commons
Jie Wang, Fanglin Shao, Qingxin Yu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

Citations

2
The Vital Role of Melatonin and Its Metabolites in the Neuroprotection and Retardation of Brain Aging DOI Open Access
Georgeta Bocheva, Dimitar Bakalov, Petar Iliev

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5122 - 5122

Published: May 8, 2024

While primarily produced in the pineal gland, melatonin's influence goes beyond its well-known role regulating sleep, nighttime metabolism, and circadian rhythms, field of chronobiology. A plethora new data demonstrates melatonin to be a very powerful molecule, being potent ROS/RNS scavenger with anti-inflammatory, immunoregulatory, oncostatic properties. Melatonin metabolites exert multiple beneficial effects cutaneous systemic aging. This review is focused on neuroprotective during has an anti-aging capacity, retarding rate healthy brain aging development age-related neurodegenerative diseases, such as Alzheimer's disease, Parkinson's Huntington's sclerosis, amyotrophic lateral etc. Melatonin, well metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) N1-acetyl-5-methoxykynuramine (AMK), can reduce oxidative damage by shielding mitochondria from dysfunction process. could also implicated treatment conditions, modifying their characteristic low-grade neuroinflammation. It either prevent initiation inflammatory responses or attenuate ongoing inflammation. Drawing current knowledge, this discusses potential benefits supplementation preventing managing cognitive impairment diseases.

Language: Английский

Citations

14
Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health DOI Creative Commons
Н. В. Семенова, N.E. Garashchenko, С. И. Колесников

et al.

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(3), P. 309 - 330

Published: June 21, 2024

Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating existence microbiome–oxidative interaction. However, biochemical basis this interaction still unclear. In narrative review, possible pathways microbiota and are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, melatonin also appear to roles. Moreover, relationship between microbiome obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, medications considered. An investigation correlation bacterial community features OS parameter changes under normal pathological conditions might provide information for determination new methods. Furthermore, such could contribute establishing a foundation determining linkers microbiome–OS association.

Language: Английский

Citations

7
Sleep–wake modulation and pathogenesis of Alzheimer disease: Suggestions for postponement and treatment DOI

Ya-Jing Liu,

Dick F. Swaab,

Jiang-Ning Zhou

et al.

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 211 - 229

Published: Jan. 1, 2025

Language: Английский

Citations

0
The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites DOI Creative Commons
Yue Dong, Sin Man Lam, Yan Li

et al.

Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Circadian Rhythm, Hypoxia, and Cellular Senescence: From Molecular Mechanisms to Targeted Strategies DOI

Tong Nie,

Eugenie Nepovimová, Qinghua Wu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177290 - 177290

Published: Jan. 1, 2025

Language: Английский

Citations

0
Lebensstiländerungen im Alter und ihr potenzieller Einfluss auf das primäre Offenwinkelglaukom DOI
Carl Erb,

Clivia Erb,

Avaz Kazakov

et al.

Klinische Monatsblätter für Augenheilkunde, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Zusammenfassung Das primäre Offenwinkelglaukom ist eine Mitochondriopathie, die über den oxidativen Stress zu einer Neuroinflammation führt und später in Neurodegeneration übergeht. Dabei sind neben dem visuellen System zahlreiche weitere Hirnareale betroffen. Da es beim Altern im Rahmen mitochondrialen Dysfunktion ebenfalls niedriggradigen chronischen Entzündungsreaktion kommt (Inflamm-Aging), überlagern sich diese entzündlichen Prozesse Alter verstärken glaukomassoziierten pathophysiologischen Vorgänge. Um aktiv diesen Entzündungsereignissen entgegenzuwirken, soll Therapie von vorhandenen Systemerkrankungen optimiert, Chronobiologie eingehalten das Mikrobiom verbessert werden. Hierfür unterstützend erhöhte physische mentale Aktivität. Somit personalisierten zieldruckorientierten Augeninnendrucksenkung auch holistische Sichtweise erforderlich, um der primäres therapeutisch gerecht

Citations

0
Impacts of circadian disruptions on behavioral rhythms in mice DOI Open Access
Changxiao Ma, Bingyi Shen, Lihong Chen

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(22)

Published: Nov. 21, 2024

Circadian rhythms are fundamental biological processes that recur approximately every 24 h, with the sleep-wake cycle or circadian behavior being a well-known example. In field of chronobiology, mice serve as valuable model animals for studying mammalian due to their genetic similarity humans and availability various tools manipulation. Monitoring locomotor activity in provides insights into impact conditions disturbances on behavior. this review, we summarized effects disturbance mice. External factors, especially light exert significant Additionally, feeding timing, food composition, ambient temperature, physical exercise contribute variations mouse. Internal including gender, age, background, clock gene mutation deletion, effective well. Understanding murine is essential gaining underlying mechanisms regulation developing potential therapeutic interventions circadian-related disorders humans.

Language: Английский

Citations

0
The Role of Melatonin in the Inflammatory Process in Patients with Hyperglycemia and Leishmania Infection DOI Creative Commons

Thalissa Mariana de Moraes Martins,

Felipe Rubin Ferrari,

Adriele Ataídes de Queiroz

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 950 - 950

Published: Aug. 6, 2024

Type 2 diabetes mellitus is a metabolic disorder that causes chronic high blood sugar levels, and diabetic patients are more susceptible to infections. American cutaneous leishmaniasis an infectious disease caused by parasite affects the skin mucous membranes, leading one or multiple ulcerative lesions. Chronic inflammation functional changes in various organs systems, including immune system, primary of both diseases. Melatonin, essential immunomodulatory, antioxidant, neuroprotective agent, can benefit many immunological processes diseases, leishmaniasis. Although, limited reports available on with The literature suggests melatonin may play promising role inflammatory disorders. This study was designed assess levels mediators affected Blood samples from 25 individuals were analyzed divided into four groups: control group (without any diseases), Leishmania-positive group, type mellitus, combination measured serum through ELISA, while IL-4 TNF-α using flow cytometry, C-reactive protein turbidimetry. found significantly increased decreased levels. However, showed higher than group. These observations suggest influence production leishmaniasis, potentially contributing characteristics

Language: Английский

Citations

0