Current Opinion in Genetics & Development, Journal Year: 2024, Volume and Issue: 89, P. 102276 - 102276
Published: Nov. 6, 2024
Language: Английский
Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Abstract Despite significant advancements in oncology research and therapeutic interventions, cancer continues to be the leading cause of mortality worldwide. The key challenge addressing this pressing issue lies lack precision diagnosis a limited understanding nature how tumor microenvironment responds interventions. Research focusing on impact (TME) heterogeneity response drugs is crucial ensure efficient therapy. Conventional models exhibit constraints, including inability accurately imitate tumors’ complex 3D architecture dynamic microenvironment. Recent developments Spheroid‐On‐a‐Chip (SoC) technology provide alternative, offering closer that human tissue. This review explores recent SoC modeling, highlighting spheroid formation mechanisms techniques. applications platform mimic essential features their potential role anticancer drug development are summarized. advantages challenges technologies behind devices compared traditional vitro further discussed. Lastly, future directions for transforming improving suggested.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123202 - 123202
Published: Feb. 19, 2025
Language: Английский
Citations
0
Tissue Engineering and Regenerative Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: May 13, 2025
Language: Английский
Citations
0
Bioengineering, Journal Year: 2024, Volume and Issue: 11(6), P. 619 - 619
Published: June 18, 2024
Biophysical factors play a fundamental role in human embryonic development. Traditional vitro models of organogenesis focused on the biochemical environment and did not consider effects mechanical forces developing tissue. While most tissue has Young’s modulus low kilopascal range, standard cell culture substrate, plasma-treated polystyrene, 3 gigapascals, making it 10,000–100,000 times stiffer than native tissues. Modern approaches attempt to recapitulate biophysical niche organs have yielded more clinically relevant Since Clevers’ conception intestinal organoids 2009, field expanded rapidly, generating stem-cell derived structures, which are transcriptionally similar fetal tissues, for nearly every organ system body. For this reason, we conjecture that will make their first clinical impact regenerative medicine as structures generated ex vivo better match Moreover, autologously sourced transplanted tissues would be able grow with embryo dynamic, environment. As organoid technologies evolve, resultant approach structure function adult may help bridge gap between preclinical drug candidates approved therapeutics. In review, discuss roles stiffness, viscoelasticity, shear formation disease development, suggesting these physical parameters should further integrated into improve physiological relevance therapeutic applicability. It also points mechanotransductive Hippo-YAP/TAZ signaling pathway key player interplay extracellular matrix cellular mechanics, pathways. We conclude by highlighting how frontiers physics can applied biology, example, quantum entanglement predict spontaneous DNA mutations. future, contemporary theories leveraged understand seemingly stochastic events during organogenesis.
Language: Английский
Citations
3
World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(10), P. 860 - 872
Published: Oct. 24, 2024
The burgeoning field of bioengineering has witnessed significant strides due to the advent stem cell models, particularly in their application advanced therapy medicinal products (ATMPs). In this review, we examine multifaceted impact these developments, emphasizing potential models enhance sophistication ATMPs and offer alternatives animal testing. Stem cell-derived tissues are promising because they can reshape preclinical landscape by providing more physiologically relevant ethically sound platforms for drug screening disease modelling. We also discuss critical challenges reproducibility accuracy measurements ensure integrity utility research application. Moreover, review highlights imperative align with regulatory standards, ensuring using cells translates into safe effective clinical therapies. With approval serving as a gateway adoption, collaborative efforts between scientists regulators vital progression applications from bench bedside. advocate balanced approach that nurtures innovation within framework rigorous validation compliance, cell-base solutions maximized promote public trust patient health ATMPs.
Language: Английский
Citations
3
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Oct. 16, 2024
Kidney disease encompasses a wide spectrum of conditions, ranging from simple infections to chronic kidney disease. When the kidneys are unable filter blood and remove waste products, these abnormalities can lead failure. In severe cases failure, transplantation is considered only definitive treatment. Worldwide, World Health Organization (WHO) repeatedly emphasizes importance organ donation increasing rates. Many countries implement national programs promote culture improve patient access transplantation. The extent which this procedure performed varies across influenced by several factors, including volume donation, medical infrastructure, technology health policies. However, transplant comes with challenges problems that impact its success. tissue engineering new approach shows promise for repairing replacing damaged tissue. This article reviews recent advances in engineering, focusing on engineered structures such as hydrogels, electrospinning, 3D bioprinting, microfluidic systems. By mimicking extracellular environment kidney, provide suitable conditions growth development cells. role formation vessels, mimicry functions field were also discussed. results study show has high potential treating diseases reducing need achieve clinical application technology, further research required biocompatibility, vascularization long-term performance tissues.
Language: Английский
Citations
1
E3S Web of Conferences, Journal Year: 2024, Volume and Issue: 505, P. 01004 - 01004
Published: Jan. 1, 2024
The technological development of biomaterials used in forming artificial organs and organoids indicates a revolutionary area within biomedical engineering the field regenerative medicine. This study provides an in-depth review recent progress biomaterials, emphasizing their design use for fabricating organoids. analysis proceeds with examining necessary parameters simulating biological biomechanical qualities local tissues. next effort turns towards synthesizing characterizing innovative including biocompatible polymers, hydrogels, bioactive scaffolds that can be tailored to suit specific organ systems. paper take on developments 3D printing microfabrication techniques, how they facilitate synthesis complicated, multicellular structures. research also examines integration when combined stem cell technologies, focusing role prospects customized medical treatments. highlights significant achieved this potential these technologies addressing limited supply organs, performing drug testing, improving knowledge growth diseases.
Language: Английский
Citations
0
Current Opinion in Genetics & Development, Journal Year: 2024, Volume and Issue: 89, P. 102276 - 102276
Published: Nov. 6, 2024
Language: Английский
Citations
0