The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia

Molecular Neurobiology, Journal Year: 2019, Volume and Issue: 57(2), P. 778 - 797

Published: Aug. 31, 2019

Language: Английский

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The Neuroimmune and Neurotoxic Fingerprint of Major Neurocognitive Psychosis or Deficit Schizophrenia: a Supervised Machine Learning Study

Neurotoxicity Research, Journal Year: 2020, Volume and Issue: 37(3), P. 753 - 771

Published: Jan. 8, 2020

Language: Английский

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The phenomenological model of depression: from methodological challenges to clinical advancements

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 31, 2023

In this article our overall aim is to illustrate how phenomenological psychopathology can advance the clinical work on depression. To do so, we start by unfolding current model of We argue that faces a methodological challenge, which define as 'the challenge patho-description'. Mental disorders, such depression, influence people are able access and describe their own experiences. This becomes for since its methodology based people's ability deal with in case turn framework interview. interview 12 participants (7 women, 5 men, age-range from 29 57 years) moderate severe From results, show deals patho-description depression conceals experiential nuances. unfold these nuances pre-reflectively experience variety feelings, type agency, overly positive self-image, relations hyper-social way. These descriptive not only strengthen but they also help firstly be added manuals rating scales diagnostic work. Secondly, phenomenological, 'bottom-up', embodied approaches function at pre-reflective level experience, further effort therapy

Language: Английский

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Losing Meaning: Philosophical Reflections on Neural Interventions and their Influence on Narrative Identity

Neuroethics, Journal Year: 2021, Volume and Issue: 14(3), P. 491 - 505

Published: May 15, 2021

Abstract The profound changes in personality, mood, and other features of the self that neural interventions can induce be disconcerting to patients, their families, caregivers. In neuroethical debate, these concerns are often addressed context possible threats narrative self. this paper, I argue it is necessary consider a dimension impacts on which has so far been neglected: lead loss meaning actions, feelings, beliefs, intentional elements our self-narratives. To uphold coherence self-narrative, induced by need accounted for through explanations or biochemical terms. However, only an explanation including states delivers content directly ascribe personal meaning, i.e., subjective value events. Neural deprive events because they may favor predominantly account. A not inherently negative but problematic, particularly if affected one was prepared willing have stripped meaning. paper further examines what about analyzing different methods. degree pull towards view occurs depends characteristics intervention. By comparing Deep Brain Stimulation, Prozac, Ritalin, psychedelics, psychotherapy, identifies some main factors: rate change, transparency causal chain, involvement patient, presence acute phenomenological experience.

Language: Английский

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Expanding Diversity, Equity, and Inclusion to Disability: Opportunities for Biological Psychiatry

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2022, Volume and Issue: 7(12), P. 1280 - 1288

Published: Aug. 28, 2022

Given its subject matter, biological psychiatry is uniquely poised to lead STEM (science, technology, engineering, and mathematics) DEI (diversity, equity, inclusion) initiatives related disability. Drawing on literatures in science, philosophy, psychiatry, disability studies, we outline how that leadership might be undertaken. We first review existing opportunities for the advancement of around axes gender race. then explore expansion psychiatry's efforts disability, especially along lines representation access, community accountability, first-person testimony, revised theoretical frameworks pathology. close with concrete recommendations scholarship practice going forward. By tackling head-on challenge inclusion, has opportunity a force transformation sciences beyond.

Language: Английский

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Moods and the Salience of Subjectivity

Published: Jan. 1, 2024

Language: Английский

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References

Published: Aug. 13, 2010

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