Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies DOI Creative Commons

Shuaiqi Wang,

Tong Huo,

Mingyang Lu

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 499 - 499

Published: March 27, 2025

Cellular senescence is an irreversible state of cell cycle arrest. Senescent cells (SCs) accumulate in the body with age and secrete harmful substances known as senescence-associated secretory phenotype (SASP), causing chronic inflammation; at same time, inflammation leads to a decrease immune system function, immunosenescence, which further accelerates aging process. immunosenescence are closely related variety diseases, including cardiovascular metabolic disorders, autoimmune neurodegenerative diseases. Studying mechanisms cellular developing targeted interventions crucial for improving function quality life elderly people. Here, we review series recent studies focusing on molecular regulation by system, latest advances basic clinical research senolytics. We summarize animal models research, well mechanisms, strategies, future directions from immunological perspective, hope laying foundation novel practical anti-aging therapies.

Language: Английский

Natural Compounds and Products from an Anti-Aging Perspective DOI Creative Commons
Geir Bjørklund, Mariia Shanaida, Roman Lysiuk

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(20), P. 7084 - 7084

Published: Oct. 20, 2022

Aging is a very complex process that accompanied by degenerative impairment in many of the major functions human body over time. This inevitable influenced hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, so on. Many external internal signs symptoms are related with aging senescence, including skin dryness wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, consequence imbalance between pro- antioxidants, one main provoking factors causing aging-related damages concerns, due to generation highly reactive byproducts oxygen nitrogen species during metabolism, which result cellular damage apoptosis. Antioxidants can prevent these processes extend healthy longevity ability inhibit formation free radicals or interrupt their propagation, thereby lowering level oxidative stress. review focuses on supporting antioxidant system organism balancing diet through consumption necessary amount natural ingredients, vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, drinking water.

Language: Английский

Citations

111
Vitamin D as a Shield against Aging DOI Open Access
Cristina Fantini, Clarissa Corinaldesi, Andrea Lenzi

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4546 - 4546

Published: Feb. 25, 2023

Aging can be seen as a physiological progression of biomolecular damage and the accumulation defective cellular components, which trigger amplify process, toward whole-body function weakening. Senescence initiates at level consists in an inability to maintain homeostasis, characterized by overexpression/aberrant expression inflammatory/immune/stress responses. is associated with significant modifications immune system cells, decline immunosurveillance, which, turn, leads chronic elevation inflammation/oxidative stress, increasing risk (co)morbidities. Albeit aging natural unavoidable it regulated some factors, like lifestyle diet. Nutrition, indeed, tackles mechanisms underlying molecular/cellular aging. Many micronutrients, i.e., vitamins elements, impact cell function. This review focuses on role exerted vitamin D geroprotection, based its ability shape cellular/intracellular processes drive response protection against infections age-related diseases. To this aim, main paths immunosenescence inflammaging are identified biotargets D. Topics such heart skeletal muscle function/dysfunction, depending status, addressed, comments hypovitaminosis correction food supplementation. research has progressed, still limitations exist translating knowledge into clinical practice, making necessary focus attention aging, especially considering growing number older individuals.

Language: Английский

Citations

56
Novel strategies for cancer immunotherapy: counter-immunoediting therapy DOI Creative Commons
Shaochuan Liu, Qian Sun,

Xiubao Ren

et al.

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: April 13, 2023

Abstract The advent of immunotherapy has made an indelible mark on the field cancer therapy, especially application immune checkpoint inhibitors in clinical practice. Although proven its efficacy and safety some tumors, many patients still have innate or acquired resistance to immunotherapy. emergence this phenomenon is closely related highly heterogeneous microenvironment formed by tumor cells after undergoing immunoediting. process immunoediting refers cooperative interaction between system that involves three phases: elimination, equilibrium, escape. During these phases, conflicting interactions result formation a complex microenvironment, which contributes acquisition different levels cells. In review, we summarize characteristics phases corresponding therapeutic tools, propose normalized strategies based immunophenotyping. retrograded through targeted interventions immunoediting, making context precision therapy most promising cure cancer.

Language: Английский

Citations

48
A comprehensive review on the utilization of probiotics in aquaculture towards sustainable shrimp farming DOI

C M Mathan Muthu,

A.S. Vickram,

B. Bhavani Sowndharya

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 147, P. 109459 - 109459

Published: Feb. 17, 2024

Language: Английский

Citations

23
Mechanisms and Strategies of Immunosenescence Effects on Non-Small Cell Lung Cancer (NSCLC) Treatment: A Comprehensive Analysis and Future Directions DOI
Huatao Zhou,

Zilong Zheng,

Chengming Fan

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 109, P. 44 - 66

Published: Jan. 9, 2025

Language: Английский

Citations

2
Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases DOI Creative Commons
Giuseppe Murdaca, Luca Tagliafico,

Elena Page

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1023 - 1023

Published: May 7, 2024

The synergic role of vitamin D and the intestinal microbiota in regulation immune system has been thoroughly described literature. Vitamin deficiency dysbiosis have shown a pathogenetic development numerous immune-mediated allergic diseases. physiological processes underlying aging sex proven to be capable having negative influence both on values biodiversity microbiome. This leads global increase levels systemic inflammatory markers, with potential implications for all diseases conditions. Our review aims collect analyze relationship between microbiome associated it, emphasizing effect mediated by sexual hormones aging.

Language: Английский

Citations

14
Adherence to an antioxidant diet and lifestyle is associated with reduced risk of cardiovascular disease and mortality among adults with nonalcoholic fatty liver disease: evidence from NHANES 1999–2018 DOI Creative Commons
Yingzi Li, Yipin Liu

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 8, 2024

Background Nonalcoholic fatty liver disease (NAFLD) stands a prevalent chronic condition significantly influenced by oxidative stress. We investigated the unclear relationship between antioxidant-rich diet and lifestyle cardiovascular (CVD) prevalence rate mortality in adult patients with NAFLD. Methods This study utilized data from National Health Nutrition Examination Survey (NHAENS) spanning 1999 to 2018 investigate association adherence an The employed Oxidative Balance Score (OBS) define antioxidant lifestyle. Results Including 8,670 NAFLD, revealed inverse OBS of most CVD conditions. Fully adjusted models demonstrated that each unit increase OBS, overall corresponded 2, 7, 2% reduction all-cause mortality, respectively. In findings Q2 Q3 were linked reduced cancer whereas did not exhibit association. Additionally, Stratified analysis age (<45 years) education level (> high school) CVD. Conclusion These results underscore protective link diminished adults particularly among younger higher-educated populations.

Language: Английский

Citations

12
Intestinal toxicity of Pb: Structural and functional damages, effects on distal organs and preventive strategies DOI

Zhihua Liu,

Shu Ai,

Yanzhou Xia

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 931, P. 172781 - 172781

Published: April 27, 2024

Language: Английский

Citations

10
Influenza and Aging: Clinical Manifestations, Complications, and Treatment Approaches in Older Adults DOI

Christian Rosero,

Stefan Gravenstein, Elie Saade

et al.

Drugs & Aging, Journal Year: 2025, Volume and Issue: 42(1), P. 39 - 55

Published: Jan. 1, 2025

Language: Английский

Citations

1
Growing old together: What we know about the influence of diet and exercise on the aging host's gut microbiome DOI Creative Commons
Chequita N. Brooks,

Madeline E. Wight,

Oluwatobi E. Azeez

et al.

Frontiers in Sports and Active Living, Journal Year: 2023, Volume and Issue: 5

Published: April 17, 2023

The immune system is critical in defending against infection from pathogenic microorganisms. Individuals with weakened systems, such as the elderly, are more susceptible to infections and developing autoimmune inflammatory diseases. gut microbiome contains a plethora of bacteria other microorganisms, which collectively plays significant role function homeostasis. Gut microbiota considered be highly influential on host health function. Therefore, dysbiosis could major contributor elevated incidence multiple age-related pathologies. While there seems general consensus that composition changes age, very little known about how diet exercise might influence aging microbiome. Here, we examine current state literature regarding alterations hosts drawing particular attention knowledge gaps addressing Further, will demonstrate need for controlled studies investigate roles play driving composition, diversity, an population.

Language: Английский

Citations

21