A Comprehensive Review on the Beneficial Roles of Vitamin D in Skin Health as a Bio-Functional Ingredient in Nutricosmetic, Cosmeceutical, and Cosmetic Applications

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 796 - 796

Published: Jan. 15, 2025

Vitamin D, also called the “sunshine” vitamin, has gained great attention recently due to observed high percentage of worldwide population being deficient in this essential bioactive vitamin. Primarily, vitamin D was known for its important role bone health. Nevertheless, recent research shown importance brain, heart, muscles, immune system, and skin health, distinct bio-functionality almost every tissue human body. Therefore, deficiency been highly correlated with multiple diseases, including dermatologically associated ones. Moreover, different methodologies are applied synthesize while main sources plasma levels factors that can cause adverse modifications multiple. Further upon exhibited notable against such as psoriasis, atopic dermatitis, vitiligo, acne, rosacea. In article, a critical review most relevant significant information regarding relationship between health is thoroughly conducted, emphasis given potential uses benefits several cosmetic applications. Current status, limitations, future perspectives potent extensively discussed.

Language: Английский

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Inflammaging and Immunosenescence as Part of Skin Aging—A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7784 - 7784

Published: April 24, 2023

Inflammaging and immunosenescence are associated with aging of the human body, but there key differences between them. Immunosenescence aims to adapt body systems aging, while inflammaging is considered a consequence immunosenescence. There has been much research in area recently, yet our understanding ability develop interventions decrease harmful effect on insufficient. This review focused processes skin. We aimed identify factors that influence inflammaging, skin their mechanisms. discussed role triggering (e.g., UV radiations, changes bioavailability nitric oxide, senescence-associated secretory phenotype factors, reactive oxygen species) inhibiting can potentially be used as anti-aging treatments, well idea geroprotectors senotherapeutics. concluded knowledge external help people improve health conditions, biochemical researchers understand process minimize impact body. Further needed better slow down or accelerate inflammaging.

Language: Английский

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Improving Cognitive Function with Nutritional Supplements in Aging: A Comprehensive Narrative Review of Clinical Studies Investigating the Effects of Vitamins, Minerals, Antioxidants, and Other Dietary Supplements

Nutrients, Journal Year: 2023, Volume and Issue: 15(24), P. 5116 - 5116

Published: Dec. 15, 2023

Cognitive impairment and dementia are burgeoning public health concerns, especially given the increasing longevity of global population. These conditions not only affect quality life individuals their families, but also pose significant economic burdens on healthcare systems. In this context, our comprehensive narrative review critically examines role nutritional supplements in mitigating cognitive decline. Amidst growing interest non-pharmacological interventions for enhancement, delves into efficacy vitamins, minerals, antioxidants, other dietary supplements. Through a systematic evaluation randomized controlled trials, observational studies, meta-analysis, focuses outcomes such as memory attention improvement, executive function support, neuroprotection. The findings suggest complex interplay between supplementation health, with some showing promising results others displaying limited or context-dependent effectiveness. highlights importance dosage, bioavailability, individual differences response to supplementation. Additionally, it addresses safety concerns potential interactions conventional treatments. By providing clear overview current scientific knowledge, aims guide professionals researchers making informed decisions about use health.

Language: Английский

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Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Journal of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: 96(4), P. 1353 - 1382

Published: Nov. 7, 2023

Diet is an important nonpharmacological risk-modifying factor for Alzheimer's disease (AD). The approaches used here to assess diet's role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational laboratory studies. Ecological studies have identified fat, meat, obesity from high-energy diets as factors reported that rates peak about 15-20 years after national dietary changes. Observational compared Western pattern with those Dietary Approaches Stop Hypertension (DASH), Mediterranean (MedDi), Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) diets. Those including higher consumption saturated total fats, ultraprocessed foods a lower fruits, legumes, nuts, omega-3 fatty acids, vegetables, whole grains. Diet-induced associated significant inflammation, insulin resistance, oxidative stress, elevated homocysteine, advanced glycation end products, trimethylamine N-oxide. molecular mechanisms by which bioactive components specific affect are discussed. Given most countries' entrenched food supply systems, upward trends would be hard reverse. However, people willing able, low-animal product diet plenty anti-inflammatory, low-glycemic load may helpful.

Language: Английский

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Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Aug. 5, 2024

Abstract Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including skeletal immune systems. Recent studies have elucidated intricate bidirectional interactions between these two In this review, we provide comprehensive synthesis molecular mechanisms cell ageing. We further discuss how age-related changes influence system consequent impact alterations on system. Finally, highlight clinical implications findings propose potential strategies to promote healthy ageing reduce pathologic both

Language: Английский

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Inflamm-ageing: how cytokines and nutrition shape the trajectory of ageing

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Population ageing is increasing in prevalence most developed countries. Ageing the decline of functional properties at cellular, tissue, and organ level. Biochemical changes that occur all organisms experience biological are referred to as "Hallmarks ageing". Inflammation a common denominator hallmarks ageing, being mechanistically involved age-related health consequences. Inflamm-ageing refers inflammatory immune systems which somehow drive process towards healthy or unhealthy ageing. Current evidences, support that, reversing pro-inflammatory status inflamm-ageing, able modulate associated with increased levels molecules (e.g. cytokines, chemokines), ultimately producing chronic low-grade state typically observed older individuals. It commonly accepted balance between pro- anti-inflammatory cytokines/chemokines one factors determining whether occurs. Malnutrition nutritional imbalances, highly prevalent elderly, playing role driving immunoactive molecules. In particular, malnutrition major risk factor for sarcopenia, phenomenon characterized by loss muscle mass, often basis frailty. Given close relationship there also evidence link Indeed, cytokine/chemokine elderly patients were demonstrated. The demonstration specific cytokines play modulating appetite nutrient sensing taste reception, provided further existence nutrition shaping trajectory present review will overview current supporting circulating chemokines inflammation, malnutrition.

Language: Английский

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Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

Cosmetics, Journal Year: 2024, Volume and Issue: 11(2), P. 37 - 37

Published: March 1, 2024

Vitamin D is a natural photoproduct that has many beneficial effects on different organs, including skin. Active forms of vitamin and its derivatives exert biological skin cells, thus maintaining homeostasis. In keratinocytes, they inhibit proliferation stimulate differentiation, have anti-inflammatory properties, act as antioxidants, DNA damage repair after ultraviolet (UV) exposure. melanocytes, also cell proliferation, apoptosis antioxidants. fibroblasts, affect fibrotic processes collagen production, promote wound healing regeneration. On the other hand, cells ability to activate directly. These activities, along with projected topical application derivatives, are promising for care photo protection can be used in prevention or possible reversal aging.

Language: Английский

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Vitamin D and Aging: Central Role of Immunocompetence

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 398 - 398

Published: Jan. 30, 2024

The pro-hormone vitamin D3 is an important modulator of both innate and adaptive immunity since its biologically active metabolite 1α,25-dihydroxyvitamin (1,25(OH)2D3) regulates via the transcription factor VDR (vitamin D receptor) epigenome transcriptome human immune cells controls in this way expression hundreds target genes. Since myeloid linage hematopoiesis epigenetically programmed by concert with pioneer factors PU.1 (purine-rich box 1) CEBPα (CCAAT/enhancer binding protein α), monocytes, macrophages, dendritic are most D-sensitive cell types. central role system various aging-related diseases suggests that immunocompetence describes not only ability individual to resist pathogens parasites but also contest non-communicative process aging itself. In review, we argue individual-specific responsiveness relates a person’s epigenetic programming function ligand 1,25(OH)2D3 during as well periphery. This may provide mechanism explaining how protects against major common and, parallel, promotes healthy aging.

Language: Английский

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Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 7211 - 7238

Published: Feb. 19, 2024

Language: Английский

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Vitamin D, a Secosteroid Hormone and Its Multifunctional Receptor, Vitamin D Receptor, in Alzheimer’s Type Neurodegeneration

Journal of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: 95(4), P. 1273 - 1299

Published: Sept. 1, 2023

Vitamin D is a secosteroid hormone exerting neurosteroid-like properties. Its well-known nuclear receptor, and recently proposed as mitochondrial transcription factor, vitamin acts for its primary functions. The second receptor an endoplasmic reticulum protein, protein disulfide isomerase A3 (PDIA3), suggested to act rapid response. has effects on various systems, particularly through calcium metabolism. Among them, the nervous system important place in context of our subject. Recent studies have shown that receptors numerous system. Neurodegeneration long-term process. Throughout human life span, so deficiency. Our previous others out-come deficiency (hypovitaminosis or inefficient utilization D), may lead neurons be vulnerable aging neurodegeneration. We suggest keeping levels at adequate all stages life, considering new approaches such agonists can activate receptors, utilizing other derivatives produced synthesis process with UVB are crucial when D-based intervention studies. Given most aspects D, this review outlines how work involved neurodegeneration, emphasizing Alzheimer’s disease.

Language: Английский

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