Joint association of sleep patterns and oxidative balance score with all-cause and cardiovascular mortality among the general population

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Background This study investigates the joint effect of sleep patterns and oxidative balance score (OBS) on all-cause CVD mortality in general population. Methods We examined 21,427 individuals aged 18–85 from NHANES 2005–2014, connecting them to data until December 31, 2019, using interview physical examination dates. Surveys collected duration, self-reported disturbance, doctor-told disorders, classified into healthy, intermediate, unhealthy patterns. OBS was calculated based twenty stress-related exposures dietary lifestyle factors. Cox proportional hazards model conducted evaluate association between or alone combined with mortality. Results Poor pro-oxidant (Q1 & Q2) were identified as risk factors for Each point increase associated a 3% decrease both There an interaction (P = 0.013). Joint analyses revealed that participants (intermediate poor) pattern significantly increased (HR 1.45 [1.21–1.74]) 1.60 [1.12–2.28]). Furthermore, stratified analysis highlighted this more prominent among without hypertension diabetes; notable younger elderly. Conclusion significant affecting Unhealthy jointly positively Interventions targeting healthy antioxidant lifestyles may promote health outcomes.

Language: Английский

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Dietary intake of live microbes and its association with frailty in older adults: a NHANES analysis (1999–2018)

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 11, 2025

Diet plays a crucial part in maintaining healthy body, and microbes, as an essential dietary component, have attracted more attention recent years. In this study, we will explore the link between intake of live microbes frailty elderly. Older participants from 1999–2018 National Health Nutrition Examination Survey (NHANES) who were not less than 60 years age enrolled research. Participants' microbe was assessed by self-report questionnaire. Participants stratified into low, medium, high groups according to their consumption foods with varying microbial content. The index 49 indicators. Frailty defined > 0.21. Logistic regression used analyze older adults. A total 15,179 adults' basic information collected for study. higher 0.21 32.8% participants. adults accounted 33.5%, 47.0%, 19.5%, respectively. models adjusted confounders, prevalence lower medium (OR = 0.825, 95%CI: 0.749–0.908) 0.779, 0.679–0.894) groups, compared lowest group. RCS analysis revealed significant non-linear association prevalence, strongest reduction observed below inflection point 161.82 (P non-linearity < 0.05). addition, analyses did reveal interactions study variables. This demonstrates negative These findings provide evidence potential frailty, warranting further longitudinal interventional studies relationship its implications aging.

Language: Английский

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The Association of Elevated Depression Levels and Life’s Essential 8 on Cardiovascular Health With Predicted Machine Learning Models and Interpretations: Evidence From NHANES 2007–2018

Depression and Anxiety, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background and Objective: The association between depression severity cardiovascular health (CVH) represented by Life's Essential 8 (LE8) was analyzed, with a novel focus on ranked levels different ages. Machine learning (ML) algorithms were also selected aimed at providing predictions to suggest practical recommendations for public awareness clinical treatment. Methods: We included 21,279 eligible participants from the National Health Nutrition Examination Survey (NHANES) 2007-2018. Weighted ordinal logistic regression (LR) utilized further sensitivity dose-response analysis, ML analyzed SHapley Additive exPlanations (SHAP) applied make interpretable results visualization. Results: Our studies demonstrated an inverse relationship LE8 elevated depressive levels, robustness confirmed through subgroup interaction analysis. Age-specific findings revealed middle-aged older adults (aged 40-60 over 60) which showed higher depresion severity, highlighting need greater targeted interventions. Eight provide predictive results, SHAP would become ideal supplement increase model interpretability. Conclusions: negative provided suite of models, generate toward implications subjective

Language: Английский

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Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 11, 2024

Background Both frailty and elevated serum neurofilament light chain (sNfL) levels are linked to cognitive impairment. However, evidence of their relationship is lacking, whether it was mediated by renal function unknown. This study aimed investigate the association between sNfL in a representative U.S. population, explore potential mediating role estimated glomerular filtration rate (eGFR) this relationship. Methods Data from 1,782 participants aged 20–75 years 2013–2014 National Health Nutrition Examination Survey (NHANES) were analyzed. Frailty assessed using 49-item index, categorized as non-frail, pre-frail, or frail. measured acoustic emission technology. Multivariable linear regression models restricted cubic spline analyses employed examine associations frailty, eGFR, levels. Mediation analysis conducted evaluate eGFR frailty-sNfL Results The prevalence pre-frailty 45.39 11.60%, respectively. A significant positive observed score (adjusted β : 39.97, SE: 11.07, p = 0.003), with confirmed analysis. Frail individuals had significantly higher compared non-frail 11.86, 5.42, 0.04). negatively associated β: -0.23, 0.05, &lt; 0.001). revealed that accounted for 12.52% total effect on ( 0.0001). Conclusion demonstrates partially These findings suggest may serve biomarker frailty-related neuronal damage highlight importance kidney association. Further research warranted clinical implications these assessment management strategies.

Language: Английский

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Association of frailty with cardiovascular and all-cause mortality in community-dwelling older adults: insights from the Chinese longitudinal healthy longevity survey

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 23, 2024

Background Previous studies suggest that frailty increases the risk of mortality, but cardiovascular disease (CVD) and all-cause mortality in Chinese community-dwelling older adults remains understudied. Our aim was to explore effect on based a large-scale prospective survey China. Methods We utilized 2014–2018 cohort Longitudinal Healthy Longevity Survey constructed index (FI) assess status. Propensity score matching used equalize baseline characteristics participants strengthen reliability findings. Hazard ratios 95% confidence intervals (CIs) were estimated using multivariate Cox models, adjusting for potential confounders, association between mortality. The relationship further explored competing model considering death as event. dose–response relationships them restricted cubic spline models. Results results found group had higher CVD (1.94, CI: 1.43–2.63) (1.87, 1.63–2.14) compared with non-frailty group. risks suggested 1.48–2.53). analysis no non-linear FI Conclusions Frail demonstrated stronger Reversing is therefore expected reduce adults.

Language: Английский

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