From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications DOI Creative Commons
Timur Saliev, Prim B. Singh

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2052 - 2052

Published: Dec. 12, 2024

Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, cellular senescence—these aim to restore youthful functionality cells tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased range strategies, including reprogramming, senolytic interventions, restoration, stem cell-based approaches, gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential preclinical models is now being cautiously explored early-stage clinical trials. However, translating these from the laboratory practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, high costs impede widespread adoption. This review examines current landscape rejuvenation, highlighting key advancements, risks, strategies needed overcome hurdles.

Language: Английский

Explorando a realidade dos exossomos na Dermatologia DOI Creative Commons
Taciana Dal’Forno‐Dini, Martina Souilljee Birck, Marco Rocha

et al.

Published: Jan. 1, 2025

Citations

0
Exosome Revolution or Marketing Mirage? AI-Based Multi-domain Evaluation of Claims, Scientific Evidence, Transparency, Public Sentiment, and Media Narratives DOI
Eqram Rahman, Karim Sayed,

Parinitha Rao

et al.

Aesthetic Plastic Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

Citations

0
Regenerative topical skincare: stem cells and exosomes DOI Creative Commons
Amy Forman Taub

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 15, 2024

Regenerative medicine and its offshoot, regenerative aesthetics, have been hot topics over the past 15 years. Studies with heterochronic parabiosis others pointed to a circulating factor that could rejuvenate aging tissues. Stem cells are known powers, but they difficult extract, grow in culture or maintain. Exosomes (EVs), extracellular vesicles from 30 150 nm, discovered be primary form of communication between Using stem cell supernatants generate desirable EVs has become heralded treatment for aesthetic treatments. Preclinical studies show many benefits including improving function fibroblasts healing wounds more rapidly. Clinical aesthetics very few. Thus, excitement generated by should tempered realism about lack available products as well scientific proof.

Language: Английский

Citations

2
From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications DOI Creative Commons
Timur Saliev, Prim B. Singh

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2052 - 2052

Published: Dec. 12, 2024

Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, cellular senescence—these aim to restore youthful functionality cells tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased range strategies, including reprogramming, senolytic interventions, restoration, stem cell-based approaches, gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential preclinical models is now being cautiously explored early-stage clinical trials. However, translating these from the laboratory practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, high costs impede widespread adoption. This review examines current landscape rejuvenation, highlighting key advancements, risks, strategies needed overcome hurdles.

Language: Английский

Citations

1