International Symposium on Ruminant Physiology: Paternal Nutrient Supply: Impacts on Physiological and Whole Animal Outcomes in Offspring DOI Creative Commons
Carl R Dahlen, Germán Darío Ramírez-Zamudio,

Kerri A Bochantin-Winders

et al.

Journal of Dairy Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Recent evidence suggests that environmental factors experienced by sires can be transmitted through the ejaculate (seminal plasma + sperm) into female reproductive tract, influencing fertilization, embryo development, and postnatal offspring outcomes. This concept is termed paternal programming. In rodents, sire nutrition was shown to directly alter outcomes sperm epigenetic signatures, DNA damage/oxidative stress, cytokine profiles, and/or seminal microbiome. Response variables impacted in rodent models, including adiposity, muscle mass, metabolic responses, performance, could have major productivity financial implications for producers if these programming responses are also present ruminant species. However, a paucity of data exist regarding ruminants. The limited literature mainly point alterations epigenome as result diet or environment. Global has been implicated models which subsequently uterine environment immune response mating. Several reports indicate development signatures plane inclusion specific feed ingredients diets (polyunsaturated fatty acids, folic acid, rumen protected methionine). Models sheep addition methionine impact methylation performance characteristics extending F3 generation, divergent planes cause altered hormone profiles insulin/glucose metabolism offspring. There almost unlimited opportunities discovery this area, but researchers encouraged target critical questions such whether extent effects common management scenarios, mechanisms inherited ruminants, interact with those maternal influence physiology, whole animal outcomes, herd flock productivity.

Language: Английский

Effects of semen inflammation on embryo implantation, placentation, pregnancy outcomes and offspring health DOI
María Santos Martínez,

Yair A. Chocobar,

Yamila Fariz

et al.

Placenta, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Connecting microbial ecology to human fertility and reproduction: perspectives from the reproductive microbiomes of animals DOI Creative Commons
Sally L. Bornbusch,

Katherine Dami

F&S Reports, Journal Year: 2025, Volume and Issue: 6, P. 45 - 49

Published: April 1, 2025

Language: Английский

Citations

0
Unfolding the complexity of epigenetics in male reproductive aging: a review of therapeutic implications DOI
Ayodeji Folorunsho Ajayi, Mega O. Oyovwi,

Goodness Olusayo Olatinwo

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Aug. 1, 2024

Language: Английский

Citations

2
More than just a number: the gut microbiota and brain function across the extremes of life DOI Creative Commons
Nathan D. Nuzum, Clara Deady, Sarah Kittel‐Schneider

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 20, 2024

Understanding the interrelationship between gut microbiota and host physiology, although still in its relative infancy, has taken important steps forward over past decade. In context of brain disorders including those characterized by neurodevelopmental neurodegenerative changes there have been advances. However, initially research involved correlational analyses, had limited translational scope, lacked functional assessments. Thus, largescale longitudinal clinical investigations that assess causation underlying mechanisms via depth analysis methods are needed. neurodegeneration research, strong causal evidence now links microbiome to Alzheimer's (AD), Parkinson's Disease (PD), as supported human-to-animal transplantation studies. Longitudinal interventions being conducted AD, PD, amyotrophic lateral sclerosis, Huntington's disease, multiple sclerosis. Neurodevelopmental also seen a boon microbiome-related autism, Attention-deficit/hyperactivity disorder, schizophrenia, which is confirming prior animal model work regarding key time-windows for infant cognition. While recent advances represent progress, fundamental knowledge gaps obstacles remain. Knowing how why at extremes life will develop our mechanistic understanding help build base we strive toward counteracting microbial missteps with precision therapeutic interventions.

Language: Английский

Citations

2
Fetal programming by the maternal microbiome of offspring behavior, and DNA methylation and gene expression within the hippocampus DOI Creative Commons
Kevin L. Gustafson, Susheel Bhanu Busi, Zachary L. McAdams

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 12, 2024

The microorganisms colonizing the gastrointestinal tract of animals, collectively referred to as gut microbiome, affect numerous host behaviors dependent on central nervous system (CNS). Studies comparing germ-free mice normally colonized have demonstrated influences microbiome anxiety-related behaviors, voluntary activity, and gene expression in CNS. Additionally, there is epidemiologic evidence supporting an intergenerational influence maternal neurodevelopment offspring behavior later life. There limited experimental however directly linking long-term neurodevelopmental outcomes, or knowledge regarding mechanisms responsible for such effects.

Language: Английский

Citations

1
Seminal plasma microbiomes, sperm parameters, and cryopreservation in a healthy fertile population DOI Creative Commons
Longlong Fu,

Yuanlei Lou,

Ying Guo

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 30, 2024

Background Recent advances in microbiome research have revealed the presence of diverse microbial communities human tissues previously thought to be sterile. The present study delves into emerging field seminal plasma microbiomics, examining relationship between semen microbes and parameters post-freezing tolerance. Methods involved a cohort healthy fertility males genome analysis using 16S rRNA characterize diversity plasma. Microbial identified unique amplicon sequence variants (ASVs) genera dominant Spearman’s correlation coefficient was used assess flora parameters. A paired t-test compare changes expression before after cryo-resuscitation. Results relevant results show that top five phyla terms abundance were Firmicutes, Bacteroidota, Proteobacteria, Actinobacteriota , Campylobacterota . Spearman highlighted association specific species parameters, Porphyromonas_asaccharolytica sperm concentration. changed significantly cryo-resuscitation, affecting taxonomic units such as Campylobacter Muribaculaceae KEGG enrichment analyses, suggesting metabolic pathways are associated with freezing. Eubacterium_coprostanoligenes Eptoniphilus_duerdenii exhibited potential impact, while Orynebacterium_tuberculostearicum demonstrated positive recovery rate progressive motile sperm. Conclusion normal fertile individuals contains microflora component is closely related quality, including sperm’s ability withstand

Language: Английский

Citations

1
Fusobacterium necrophorum and Fusobacterium varium are commensal members of the bovine reproductive microbiota and may colonize calf prenatally DOI Creative Commons

Justine Kilama,

Carl R Dahlen,

Mina Abbasi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

ABSTRACT Fusobacterium necrophorum is an important pathogen associated with several infectious diseases in cattle. However, recent sequencing-based studies have indicated that F. positively pregnancy beef cows and the most abundant genus bull seminal microbiota, suggesting potential role of reproductive health fertility. Here, we performed a comprehensive screening to 1) determine whether (subspecies [FNN] funduliforme [FNF]), varium (FV) are part commensal members microbiota cattle; 2) explore these spp. colonized calf prenatally. For this, screened 11 different sample types including bovine ram semen, vaginal uterine swabs, fecal samples, as well samples from 180- 260-days old fetuses their respective dams using both quantitative PCR (514 samples) targeted culturing (499 samples). By qPCR, all were detected across types, FNF being highly prevalent semen (66.7%) maternal ruminal fluids (87.1%), which was confirmed by culturing. All identified (3.1%-9.4%) placental caruncles, fetal fluids, meconium (2.7% - 26.3%) qPCR not isolated culture method. Overall, our results suggest member healthy male FNF, FNN FV present vagino-uterine intestine

Language: Английский

Citations

1
The paternal contribution to shaping the health of future generations DOI
Christopher Casciaro, Hirotaka Hamada, Enrrico Bloise

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
International Symposium on Ruminant Physiology: Paternal Nutrient Supply: Impacts on Physiological and Whole Animal Outcomes in Offspring DOI Creative Commons
Carl R Dahlen, Germán Darío Ramírez-Zamudio,

Kerri A Bochantin-Winders

et al.

Journal of Dairy Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Recent evidence suggests that environmental factors experienced by sires can be transmitted through the ejaculate (seminal plasma + sperm) into female reproductive tract, influencing fertilization, embryo development, and postnatal offspring outcomes. This concept is termed paternal programming. In rodents, sire nutrition was shown to directly alter outcomes sperm epigenetic signatures, DNA damage/oxidative stress, cytokine profiles, and/or seminal microbiome. Response variables impacted in rodent models, including adiposity, muscle mass, metabolic responses, performance, could have major productivity financial implications for producers if these programming responses are also present ruminant species. However, a paucity of data exist regarding ruminants. The limited literature mainly point alterations epigenome as result diet or environment. Global has been implicated models which subsequently uterine environment immune response mating. Several reports indicate development signatures plane inclusion specific feed ingredients diets (polyunsaturated fatty acids, folic acid, rumen protected methionine). Models sheep addition methionine impact methylation performance characteristics extending F3 generation, divergent planes cause altered hormone profiles insulin/glucose metabolism offspring. There almost unlimited opportunities discovery this area, but researchers encouraged target critical questions such whether extent effects common management scenarios, mechanisms inherited ruminants, interact with those maternal influence physiology, whole animal outcomes, herd flock productivity.

Language: Английский

Citations

0