Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI DOI Creative Commons
Miloš Ajčević,

Katerina Iscra,

Giovanni Furlanis

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 10, 2023

Cognitive impairment is one of the most prevalent symptoms post Severe Acute Respiratory Syndrome COronaVirus 2 (SARS-CoV-2) state, which known as Long COVID. Advanced neuroimaging techniques may contribute to a better understanding pathophysiological brain changes and underlying mechanisms in post-COVID-19 subjects. We aimed at investigating regional cerebral perfusion alterations subjects who reported subjective cognitive after mild SARS-CoV-2 infection, using non-invasive Arterial Spin Labeling (ASL) MRI technique analysis. Using MRI-ASL image processing, we investigated 24 patients (53.0 ± 14.5 years, 15F/9M) with persistent complaints COVID-19 period. Voxelwise region-of-interest analyses were performed identify statistically significant differences blood flow (CBF) maps between patients, age sex matched healthy controls (54.8 9.1 13F/9M). The results showed hypoperfusion widespread network group, predominantly affecting frontal cortex, well parietal temporal identified by non-parametric permutation testing (p < 0.05, FWE-corrected TFCE). areas right hemisphere regions more extensive. These findings support hypothesis large dysfunction post-COVID complaints. nature ASL-MRI method play an important role monitoring prognosis

Language: Английский

SARS-CoV-2 is associated with changes in brain structure in UK Biobank DOI Creative Commons
Gwenaëlle Douaud, Soojin Lee, Fidel Alfaro‐Almagro

et al.

Nature, Journal Year: 2022, Volume and Issue: 604(7907), P. 697 - 707

Published: March 7, 2022

There is strong evidence of brain-related abnormalities in COVID-19

Language: Английский

Citations

1277

Nervous system consequences of COVID-19 DOI Open Access
Serena Spudich, Avindra Nath

Science, Journal Year: 2022, Volume and Issue: 375(6578), P. 267 - 269

Published: Jan. 20, 2022

Neurological symptoms highlight the need to understand pathophysiologic mechanisms.

Language: Английский

Citations

377

Changes in cognitive functioning after COVID‐19: A systematic review and meta‐analysis DOI
Lucía Crivelli, Katie Palmer, Ismael Luis Calandri

et al.

Alzheimer s & Dementia, Journal Year: 2022, Volume and Issue: 18(5), P. 1047 - 1066

Published: March 17, 2022

Abstract Introduction We conducted a systematic review and meta‐analysis of the cognitive effects coronavirus disease 2019 (COVID‐19) in adults with no prior history impairment. Methods Searches Medline/Web Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews Meta‐Analyses (PRISMA) guidelines. A Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID‐19 healthy controls was performed. Results Oof 6202 articles, 27 studies 2049 individuals included (mean age = 56.05 years, evaluation time ranged acute phase 7 months post‐infection). Impairment executive functions, attention, memory found post‐COVID‐19 patients. The subgroup 290 showed difference MoCA between patients versus −0.94, 95% confidence interval [CI] −1.59, −0.29; P .0049). Discussion Patients have lower general cognition compared up post‐infection.

Language: Английский

Citations

267

Long COVID and its Management DOI Creative Commons

Ho Cheng Koc,

Jing Xiao,

Weiwei Liu

et al.

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(12), P. 4768 - 4780

Published: Jan. 1, 2022

The pandemic of COVID-19 is the biggest public health crisis in 21

Language: Английский

Citations

223

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients DOI Creative Commons
Fernanda Crunfli, Victor Corasolla Carregari, Flávio P. Veras

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(35)

Published: Aug. 11, 2022

Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term dysfunction (recently characterized as part of "long COVID-19" syndrome) has been frequently observed after mild infection. We show the spectrum cerebral impact acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety symptoms) to damage confirmed brain tissue samples extracted orbitofrontal region (via endonasal transethmoidal access) who died COVID-19. In an independent cohort 26 COVID-19, we used histopathological signs a guide for possible SARS-CoV-2 infection found that among 5 exhibited those signs, all them had genetic material virus brain. Brain these five patients also foci replication, particularly astrocytes. Supporting hypothesis astrocyte neural stem cell-derived human astrocytes vitro are susceptible through noncanonical mechanism involves spike-NRP1 interaction. SARS-CoV-2-infected manifested changes energy metabolism key proteins metabolites fuel neurons, well biogenesis neurotransmitters. Moreover, elicits secretory phenotype reduces neuronal viability. Our data support model which reaches brain, infects astrocytes, consequently, leads death or dysfunction. These deregulated processes could contribute structural functional seen brains patients.

Language: Английский

Citations

208

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery DOI Creative Commons
Justin J. Frere, Randal A. Serafini, Kerri D. Pryce

et al.

Science Translational Medicine, Journal Year: 2022, Volume and Issue: 14(664)

Published: June 7, 2022

The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying COVID biology, we compared short- and long-term systemic responses golden hamster after either SARS-CoV-2 influenza A virus (IAV) infection. Results demonstrated that exceeded IAV its capacity cause permanent injury lung kidney uniquely affected olfactory bulb (OB) epithelium (OE). Despite a lack detectable infectious virus, OB OE myeloid T cell activation, proinflammatory cytokine production, an interferon correlated with behavioral changes extending month viral clearance. These sustained transcriptional could also be corroborated from tissue isolated individuals who recovered COVID-19. data highlight molecular for persistent symptomology provide small animal model explore future therapeutics.

Language: Английский

Citations

198

One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China DOI Open Access

Yu-Hui Liu,

Yang Chen, Qinghua Wang

et al.

JAMA Neurology, Journal Year: 2022, Volume and Issue: 79(5), P. 509 - 509

Published: March 8, 2022

Importance

Determining the long-term impact of COVID-19 on cognition is important to inform immediate steps in research and health policy.

Objective

To investigate 1-year trajectory cognitive changes older survivors.

Design, Setting, Participants

This cohort study recruited 3233 survivors 60 years who were discharged from 3 COVID-19–designated hospitals Wuhan, China, February 10 April 10, 2020. Their uninfected spouses (N = 466) as a control population. Participants with preinfection impairment, concomitant neurological disorder, or family history dementia excluded, well those severe cardiac, hepatic, kidney disease any kind tumor. Follow-up monitoring functioning decline took place at 6 12 months. A total 1438 438 individuals included final follow-up. was categorized nonsevere following American Thoracic Society guidelines.

Main Outcomes Measures

The main outcome change 1 year after patient discharge. Cognitive during first second 6-month follow-up periods assessed using Informant Questionnaire Decline Elderly Telephone Interview Status-40, respectively. Based observed 2 periods, trajectories classified into 4 categories: stable cognition, early-onset decline, late-onset progressive decline. Multinomial conditional logistical regression models used identify factors associated risk

Results

Among 1317 screened, participants treated for (691 male [48.05%] 747 female [51.95%]; median [IQR] age, 69 [66-74] years) (222 [50.68%] 216 [49.32%]; 67 completed 12-month incidence impairment months discharge 12.45%. Individuals cases had lower Status-40 scores than (median [IQR]: severe, 22.50 [16.00-28.00]; nonsevere, 30.00 [26.00-33.00]; control, 31.00 [26.00-33.00]). Severe higher (odds ratio [OR], 4.87; 95% CI, 3.30-7.20), (OR, 7.58; 3.58-16.03), 19.00; 9.14-39.51), while 1.71; 1.30-2.27) when adjusting sex, education level, body mass index, comorbidities.

Conclusions Relevance

In this study, survival an increase longitudinal highlighting importance measures deal challenge.

Language: Английский

Citations

192

ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature DOI Creative Commons
Anthony L. Komaroff, W. Ian Lipkin

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 2, 2023

Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance other symptoms that greatly interfere with their ability to function can leave some people housebound disabled. The illness (Long COVID) is similar myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well persisting illnesses follow a wide variety of infectious agents following major traumatic injury. Together, these are projected cost the U.S. trillions dollars. In this review, we first compare ME/CFS Long COVID, noting considerable similarities few differences. We then in extensive detail underlying pathophysiology two conditions, focusing on abnormalities central autonomic nervous system, lungs, heart, vasculature, immune gut microbiome, energy metabolism redox balance. This comparison highlights how strong evidence each abnormality, illness, helps set priorities future investigation. review provides current road map literature biology both illnesses.

Language: Английский

Citations

183

Slow but evident recovery from neocortical dysfunction and cognitive impairment in a series of chronic COVID-19 patients DOI Creative Commons
Ganna Blazhenets, Nils Schröter, Tobias Bormann

et al.

Journal of Nuclear Medicine, Journal Year: 2021, Volume and Issue: unknown, P. jnumed.121.262128 - jnumed.121.262128

Published: March 31, 2021

Cognitive impairment is a frequent complaint in coronavirus disease 2019 (COVID-19) and can be related to cortical hypometabolism on 18F-FDG PET at the subacute stage. However, it unclear if these changes are reversible. Methods: We prospectively assessed Montreal Assessment scores scans of 8 COVID-19 patients stage (once no longer infectious) chronic (˜6 mo after symptom onset). The expression previously established COVID-19-related covariance pattern was analyzed both stages examine time course post-COVID-19 cognitive impairment. For further validation, we also conducted conventional group analysis. Results: Follow-up revealed that there significant reduction initial frontoparietal and, lesser extent, temporal this accompanied by improvement cognition. significantly lower follow-up correlated inversely with performance. assessment suggest residual Conclusion: Although recovery regional neuronal function cognition clearly stated, residuals still measurable some 6 manifestation COVID-19. Given current pandemic situation tremendous uncertainty concerning long-term effects COVID-19, present study provides novel insights highest medical socioeconomic relevance.

Language: Английский

Citations

155

COVID-19 associated cognitive impairment: A systematic review DOI
José Wagner Leonel Tavares-Júnior, Ana Célia Caetano de Souza,

José W.P. Borges

et al.

Cortex, Journal Year: 2022, Volume and Issue: 152, P. 77 - 97

Published: April 18, 2022

Language: Английский

Citations

144