SARS-CoV-2 is associated with changes in brain structure in UK Biobank

Nature, Journal Year: 2022, Volume and Issue: 604(7907), P. 697 - 707

Published: March 7, 2022

There is strong evidence of brain-related abnormalities in COVID-19

Language: Английский

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Nervous system consequences of COVID-19

Science, Journal Year: 2022, Volume and Issue: 375(6578), P. 267 - 269

Published: Jan. 20, 2022

Neurological symptoms highlight the need to understand pathophysiologic mechanisms.

Language: Английский

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Changes in cognitive functioning after COVID‐19: A systematic review and meta‐analysis

Alzheimer s & Dementia, Journal Year: 2022, Volume and Issue: 18(5), P. 1047 - 1066

Published: March 17, 2022

Abstract Introduction We conducted a systematic review and meta‐analysis of the cognitive effects coronavirus disease 2019 (COVID‐19) in adults with no prior history impairment. Methods Searches Medline/Web Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews Meta‐Analyses (PRISMA) guidelines. A Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID‐19 healthy controls was performed. Results Oof 6202 articles, 27 studies 2049 individuals included (mean age = 56.05 years, evaluation time ranged acute phase 7 months post‐infection). Impairment executive functions, attention, memory found post‐COVID‐19 patients. The subgroup 290 showed difference MoCA between patients versus −0.94, 95% confidence interval [CI] −1.59, −0.29; P .0049). Discussion Patients have lower general cognition compared up post‐infection.

Language: Английский

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Long COVID and its Management

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(12), P. 4768 - 4780

Published: Jan. 1, 2022

The pandemic of COVID-19 is the biggest public health crisis in 21

Language: Английский

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Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(35)

Published: Aug. 11, 2022

Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term dysfunction (recently characterized as part of "long COVID-19" syndrome) has been frequently observed after mild infection. We show the spectrum cerebral impact acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety symptoms) to damage confirmed brain tissue samples extracted orbitofrontal region (via endonasal transethmoidal access) who died COVID-19. In an independent cohort 26 COVID-19, we used histopathological signs a guide for possible SARS-CoV-2 infection found that among 5 exhibited those signs, all them had genetic material virus brain. Brain these five patients also foci replication, particularly astrocytes. Supporting hypothesis astrocyte neural stem cell-derived human astrocytes vitro are susceptible through noncanonical mechanism involves spike-NRP1 interaction. SARS-CoV-2-infected manifested changes energy metabolism key proteins metabolites fuel neurons, well biogenesis neurotransmitters. Moreover, elicits secretory phenotype reduces neuronal viability. Our data support model which reaches brain, infects astrocytes, consequently, leads death or dysfunction. These deregulated processes could contribute structural functional seen brains patients.

Language: Английский

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SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery

Science Translational Medicine, Journal Year: 2022, Volume and Issue: 14(664)

Published: June 7, 2022

The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying COVID biology, we compared short- and long-term systemic responses golden hamster after either SARS-CoV-2 influenza A virus (IAV) infection. Results demonstrated that exceeded IAV its capacity cause permanent injury lung kidney uniquely affected olfactory bulb (OB) epithelium (OE). Despite a lack detectable infectious virus, OB OE myeloid T cell activation, proinflammatory cytokine production, an interferon correlated with behavioral changes extending month viral clearance. These sustained transcriptional could also be corroborated from tissue isolated individuals who recovered COVID-19. data highlight molecular for persistent symptomology provide small animal model explore future therapeutics.

Language: Английский

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One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China

JAMA Neurology, Journal Year: 2022, Volume and Issue: 79(5), P. 509 - 509

Published: March 8, 2022

Importance

Determining the long-term impact of COVID-19 on cognition is important to inform immediate steps in research and health policy.

Objective

To investigate 1-year trajectory cognitive changes older survivors.

Design, Setting, Participants

This cohort study recruited 3233 survivors 60 years who were discharged from 3 COVID-19–designated hospitals Wuhan, China, February 10 April 10, 2020. Their uninfected spouses (N = 466) as a control population. Participants with preinfection impairment, concomitant neurological disorder, or family history dementia excluded, well those severe cardiac, hepatic, kidney disease any kind tumor. Follow-up monitoring functioning decline took place at 6 12 months. A total 1438 438 individuals included final follow-up. was categorized nonsevere following American Thoracic Society guidelines.

Main Outcomes Measures

The main outcome change 1 year after patient discharge. Cognitive during first second 6-month follow-up periods assessed using Informant Questionnaire Decline Elderly Telephone Interview Status-40, respectively. Based observed 2 periods, trajectories classified into 4 categories: stable cognition, early-onset decline, late-onset progressive decline. Multinomial conditional logistical regression models used identify factors associated risk

Results

Among 1317 screened, participants treated for (691 male [48.05%] 747 female [51.95%]; median [IQR] age, 69 [66-74] years) (222 [50.68%] 216 [49.32%]; 67 completed 12-month incidence impairment months discharge 12.45%. Individuals cases had lower Status-40 scores than (median [IQR]: severe, 22.50 [16.00-28.00]; nonsevere, 30.00 [26.00-33.00]; control, 31.00 [26.00-33.00]). Severe higher (odds ratio [OR], 4.87; 95% CI, 3.30-7.20), (OR, 7.58; 3.58-16.03), 19.00; 9.14-39.51), while 1.71; 1.30-2.27) when adjusting sex, education level, body mass index, comorbidities.

Conclusions Relevance

In this study, survival an increase longitudinal highlighting importance measures deal challenge.

Language: Английский

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ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 2, 2023

Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance other symptoms that greatly interfere with their ability to function can leave some people housebound disabled. The illness (Long COVID) is similar myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well persisting illnesses follow a wide variety of infectious agents following major traumatic injury. Together, these are projected cost the U.S. trillions dollars. In this review, we first compare ME/CFS Long COVID, noting considerable similarities few differences. We then in extensive detail underlying pathophysiology two conditions, focusing on abnormalities central autonomic nervous system, lungs, heart, vasculature, immune gut microbiome, energy metabolism redox balance. This comparison highlights how strong evidence each abnormality, illness, helps set priorities future investigation. review provides current road map literature biology both illnesses.

Language: Английский

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Slow but evident recovery from neocortical dysfunction and cognitive impairment in a series of chronic COVID-19 patients

Journal of Nuclear Medicine, Journal Year: 2021, Volume and Issue: unknown, P. jnumed.121.262128 - jnumed.121.262128

Published: March 31, 2021

Cognitive impairment is a frequent complaint in coronavirus disease 2019 (COVID-19) and can be related to cortical hypometabolism on 18F-FDG PET at the subacute stage. However, it unclear if these changes are reversible. Methods: We prospectively assessed Montreal Assessment scores scans of 8 COVID-19 patients stage (once no longer infectious) chronic (˜6 mo after symptom onset). The expression previously established COVID-19-related covariance pattern was analyzed both stages examine time course post-COVID-19 cognitive impairment. For further validation, we also conducted conventional group analysis. Results: Follow-up revealed that there significant reduction initial frontoparietal and, lesser extent, temporal this accompanied by improvement cognition. significantly lower follow-up correlated inversely with performance. assessment suggest residual Conclusion: Although recovery regional neuronal function cognition clearly stated, residuals still measurable some 6 manifestation COVID-19. Given current pandemic situation tremendous uncertainty concerning long-term effects COVID-19, present study provides novel insights highest medical socioeconomic relevance.

Language: Английский

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COVID-19 associated cognitive impairment: A systematic review

Cortex, Journal Year: 2022, Volume and Issue: 152, P. 77 - 97

Published: April 18, 2022

Language: Английский

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