Comparative analysis of glymphatic system alterations in multiple sclerosis and neuromyelitis optica spectrum disorder using MRI indices from diffusion tensor imaging DOI Creative Commons
Minchul Kim, Inpyeong Hwang, Jung‐Hyun Park

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: April 1, 2024

The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance. Glymphatic dysfunction has been observed in both multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), indicating the role of neuroinflammation system. However, little known about how two diseases differently affect human present study aims to evaluate diffusion MRI-based measures by contrasting MS NMOSD.

Language: Английский

Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease DOI Creative Commons
Koji Kamagata, Christina Andica, Kaito Takabayashi

et al.

Neurology, Journal Year: 2022, Volume and Issue: 99(24)

Published: Sept. 19, 2022

The glymphatic system is a whole-brain perivascular network, which promotes CSF/interstitial fluid exchange. Alterations to this may play pivotal role in amyloid β (Aβ) accumulation. However, its involvement Alzheimer disease (AD) pathogenesis not fully understood. Here, we investigated the changes noninvasive MRI measurements related network patients with mild cognitive impairment (MCI) and AD. Additionally, explored associations of measures neuropsychological score, PET standardized uptake value ratio (SUVR), Aβ deposition.

Language: Английский

Citations

167
Magnetic ResonanceImages Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction inAlzheimer Disease DOI Creative Commons

Jung‐Lung Hsu,

Yi‐Chia Wei, Cheng‐Hong Toh

et al.

Annals of Neurology, Journal Year: 2022, Volume and Issue: 93(1), P. 164 - 174

Published: Oct. 10, 2022

Objective The glymphatic system cleans amyloid and tau proteins from the brain in animal studies of Alzheimer disease (AD). However, there is no direct evidence showing this humans. Methods Participants (n = 50, 62.6 ± 5.4 years old, 36 women) with AD normal controls underwent positron emission tomography (PET), PET, structural T1‐weighted magnetic resonance imaging, neuropsychological evaluation. Whole‐brain activity was measured by diffusion tensor image analysis along perivascular space (DTI‐ALPS). Results ALPS‐indexes showed negative correlations deposition on PET images positive cognitive scores even after adjusting for age, sex, education, APOE4 genotype covariates multiple AD‐related regions (all p < 0.05). Mediation that ALPS‐index acted as a significant mediator between regional standardized uptake value ratios dysfunction correcting regions. These are responsible attention, memory, executive function, which vulnerable to sleep deprivation. Interpretation Glymphatic may act gray matter volumes. provide useful progression or treatment biomarkers patients an indicator modulation activity. ANN NEUROL 2023;93:164–174

Language: Английский

Citations

115
Astrocyte Endfeet in Brain Function and Pathology: Open Questions DOI
Blanca Díaz‐Castro, Stefanie Robel, Anusha Mishra

et al.

Annual Review of Neuroscience, Journal Year: 2023, Volume and Issue: 46(1), P. 101 - 121

Published: Feb. 28, 2023

Astrocyte endfeet enwrap the entire vascular tree within central nervous system, where they perform important functions in regulating blood-brain barrier (BBB), cerebral blood flow, nutrient uptake, and waste clearance. Accordingly, astrocyte contain specialized organelles proteins, including local protein translation machinery highly organized scaffold which anchor channels, transporters, receptors, enzymes critical for astrocyte-vascular interactions. Many neurological diseases are characterized by loss of polarization specific endfoot dysregulation, BBB disruption, altered clearance, or, extreme cases, coverage. A role has been demonstrated or postulated many these conditions. This review provides an overview development, composition, function, pathological changes highlights gaps our knowledge that future research should address.

Language: Английский

Citations

89
Glymphatic imaging: a critical look at the DTI-ALPS index DOI Creative Commons
Geir Ringstad

Neuroradiology, Journal Year: 2024, Volume and Issue: 66(2), P. 157 - 160

Published: Jan. 10, 2024

Language: Английский

Citations

67
Glymphatic system impairment in Alzheimer’s disease: associations with perivascular space volume and cognitive function DOI
Xue Zhang, Yue Wang,

Bingjie Jiao

et al.

European Radiology, Journal Year: 2023, Volume and Issue: 34(2), P. 1314 - 1323

Published: Aug. 23, 2023

Language: Английский

Citations

60
Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method DOI Creative Commons
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi

et al.

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

Citations

58
Multiple Sclerosis: Inflammatory and Neuroglial Aspects DOI Creative Commons
Giulio Papiri,

Giordano D’Andreamatteo,

Gabriella Cacchiò

et al.

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(2), P. 1443 - 1470

Published: Feb. 8, 2023

Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of central nervous system (CNS). Its pathogenesis, in parallel with well-established role mechanisms pertaining to autoimmunity, involves several key functions immune, glial and nerve cells. The disease’s natural history is complex, heterogeneous may evolve over a relapsing-remitting (RRMS) or progressive (PPMS/SPMS) course. Acute inflammation, driven by infiltration peripheral cells CNS, thought be relevant process during earliest phases RRMS, while disruption neural pathways energy metabolism, survival cascades, synaptic ionic homeostasis are mostly long-standing disease, such as forms. In this complex scenario, many originally distinctive neurodegenerative disorders being increasingly recognized crucial from beginning disease. present review aims at highlighting between MS, autoimmune diseases biology disorders. fact, there an unmet need explore new targets that might involved master regulators inflammation

Language: Английский

Citations

48
Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study DOI Creative Commons
Yu Tian, Xueli Cai,

Yijun Zhou

et al.

Stroke and Vascular Neurology, Journal Year: 2023, Volume and Issue: 8(5), P. e002191 - e002191

Published: April 12, 2023

This study aims to investigate the associations of glymphatic system with presence, severity and neuroimaging phenotypes cerebral small vessel disease (CSVD) in a community-based population.This report included 2219 community-dwelling people aged 50-75 years who participated PolyvasculaR Evaluation for Cognitive Impairment vaScular Events cohort. The diffusivity along perivascular spaces based on diffusion tensor imaging (DTI-ALPS index) was measured assess pathway. presence CSVD were estimated using score (points from 0 4) modified 4), which driven by 4 features CSVD, including white matter hyperintensity (WMH), enlarged (EPVS), lacunes, microbleeds. Brain atrophy (BA) also evaluated. Binary or ordinal logistic regression analyses carried out relationships DTI-ALPS index CSVD.The mean age 61.3 (SD 6.6) years, 1019 (45.9%) participants men. average 1.67±0.14. Individuals first quartile (Q1) had higher risks (OR 1.77, 95% CI 1.33 2.35, p<0.001), (odds ratio (OR) 1.80, 1.38 2.34, total burden (common OR (cOR) 1.89, 1.43 2.49, p<0.001) (cOR 1.95, 1.51 2.50, compared those fourth (Q4). Additionally, individuals Q1 increased WMH burden, basal ganglia-EPVS BA (all p<0.05).A lower underlay typical markers implying that impairment may interact CSVD-related pathology general ageing population.NCT03178448.

Language: Английский

Citations

47
Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease DOI Creative Commons

Shu‐Yi Huang,

Ya‐Ru Zhang,

Yu Guo

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(5), P. 3251 - 3269

Published: March 19, 2024

Abstract INTRODUCTION Although glymphatic function is involved in Alzheimer's disease (AD), its potential for predicting the pathological and clinical progression of AD sequential association with core biomarkers poorly understood. METHODS Whole‐brain activity was measured by diffusion tensor image analysis along perivascular space (DTI‐ALPS) participants dementia ( n = 47), mild cognitive impairment (MCI; 137), normal controls 235) from Disease Neuroimaging Initiative. RESULTS ALPS index significantly lower than MCI or controls. Lower associated faster changes amyloid positron emission tomography (PET) burden signature region interest volume, higher risk amyloid‐positive transition progression, rates amyloid‐ neurodegeneration‐related decline. Furthermore, associations decline were fully mediated PET brain atrophy. DISCUSSION Glymphatic failure may precede pathology, predicts deposition, neurodegeneration, AD. Highlights The (ALPS) reduced patients (AD) dementia, prodromal AD, preclinical predicted accelerated beta (Aβ) Aβ‐positive transition. decrease occurs before cerebrospinal fluid Aβ42 reaches positive threshold. atrophy, Aβ atrophy link

Language: Английский

Citations

42
The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants DOI Creative Commons
Hui Hong,

Luwei Hong,

Xiao Luo

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 20, 2024

Abstract Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel (CSVD) the most common pathogenesis We hypothesize that AD and CSVD could be associated glymphatic dysfunction, contributing to cognitive impairment. Method Participants completed amyloid PET, diffusion tensor imaging (DTI), T2 fluid-attenuated inversion-recovery (FLAIR) sequences were included from Disease Neuroimaging Initiative (ADNI). White matter hyperintensities (WMH), marker, was evaluated T2FLAIR images represented burden of CSVD. Amyloid PET used assess Aβ aggregation in brain. image analysis along perivascular space (DTI-ALPS) index, enlarged spaces (PVS), choroid plexus volume reflect function. The relationships between WMH burden/Aβ these markers as well correlations function investigated. Furthermore, we conducted mediation analyses explore potential mediating effects relationship cognition. Results One hundred thirty-three participants continuum included, consisting 40 CN − , 48 + 26 MCI 19 participants. Our findings revealed there negative associations whole-brain ( r = 0.249, p 0.022) 0.458, < 0.001) DTI-ALPS. Additionally, 0.223, 0.041) 0.294, 0.006) both positively volume. However, did not observe significant PVS enlargement severity. DTI-ALPS memory 0.470, FDR- 0.001), executive 0.358, visual-spatial 0.040), language 0.419, 0.001). Conversely, showed 0.315, 0.007), 0.321, 0.233, 0.031), 0.261, 0.021). There no severity performance. In analysis, found acted mediator accumulation performances. Conclusion study provided evidence pathology (Aβ) which further related These results may provide theoretical basis new targets treating AD.

Language: Английский

Citations

28