Targetability of the neurovascular unit in inflammatory diseases of the central nervous system DOI

Brandon C. Smith,

Rachel A. Tinkey,

Benjamin C. Shaw

et al.

Immunological Reviews, Journal Year: 2022, Volume and Issue: 311(1), P. 39 - 49

Published: July 31, 2022

Summary The blood–brain barrier (BBB) is a selectively permeable separating the periphery from central nervous system (CNS). BBB restricts flow of most material into and out CNS, including many drugs that could be used as potent therapies. permeability modulated by several cells are collectively called neurovascular unit (NVU). NVU consists specialized CNS endothelial (ECs), pericytes, astrocytes, microglia, neurons. ECs maintain complex “seal” via tight junctions, forming BBB; breakdown these junctions leads to disruption. Pericytes control vascular within capillaries help basal lamina. Astrocytes much has moved beyond EC layer can form secondary under inflammatory conditions. Microglia survey border for noxious material. Neuronal activity also plays role in maintenance BBB. Since neurons all able modulate BBB, understating contributions each member will potentially uncover novel effective methods delivery neurotherapies CNS.

Language: Английский

Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease DOI
Ting Lei, Zixiao Yang, Hanmei Li

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115219 - 115219

Published: Feb. 23, 2024

Language: Английский

Citations

10
Glucose metabolism impairment in major depressive disorder DOI Creative Commons

Fanhao Meng,

Jing Wang, Long Wang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111191 - 111191

Published: Jan. 7, 2025

Major depressive disorder (MDD) is a common mental with chronic tendencies that seriously affect regular work, life, and study. However, its exact pathogenesis remains unclear. Patients MDD experience systemic localized impairments in glucose metabolism throughout the disease course, disrupting various processes such as uptake, glycoprotein transport, glycolysis, tricarboxylic acid cycle (TCA), oxidative phosphorylation (OXPHOS). These may result from mechanisms including insulin resistance, hyperglycemia-induced damage, stress, astrocyte abnormalities, mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, functional structural damage reward networks. mechanical changes contribute of severely interfere prognosis. Herein, we summarized impairment pathophysiological patients MDD. In addition, briefly discussed potential pharmacological interventions for alleviate MDD, glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, pioglitazone, encourage development new therapeutics.

Language: Английский

Citations

1
Astrocytes in aging DOI Creative Commons
Lara Labarta-Bajo, Nicola J. Allen

Neuron, Journal Year: 2025, Volume and Issue: 113(1), P. 109 - 126

Published: Jan. 1, 2025

Language: Английский

Citations

1
Towards a better diagnosis and treatment of dementia: Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia DOI Creative Commons
Alisa Vollhardt, Lutz Froelich,

Anna Stockbauer

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106845 - 106845

Published: Feb. 1, 2025

Language: Английский

Citations

1
Targetability of the neurovascular unit in inflammatory diseases of the central nervous system DOI

Brandon C. Smith,

Rachel A. Tinkey,

Benjamin C. Shaw

et al.

Immunological Reviews, Journal Year: 2022, Volume and Issue: 311(1), P. 39 - 49

Published: July 31, 2022

Summary The blood–brain barrier (BBB) is a selectively permeable separating the periphery from central nervous system (CNS). BBB restricts flow of most material into and out CNS, including many drugs that could be used as potent therapies. permeability modulated by several cells are collectively called neurovascular unit (NVU). NVU consists specialized CNS endothelial (ECs), pericytes, astrocytes, microglia, neurons. ECs maintain complex “seal” via tight junctions, forming BBB; breakdown these junctions leads to disruption. Pericytes control vascular within capillaries help basal lamina. Astrocytes much has moved beyond EC layer can form secondary under inflammatory conditions. Microglia survey border for noxious material. Neuronal activity also plays role in maintenance BBB. Since neurons all able modulate BBB, understating contributions each member will potentially uncover novel effective methods delivery neurotherapies CNS.

Language: Английский

Citations

32