Functional to structural plasticity in unilateral sudden sensorineural hearing loss: neuroimaging evidence DOI Creative Commons
Yuting Li,

Ke Bai,

G D Li

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 283, P. 120437 - 120437

Published: Nov. 3, 2023

A cortical plasticity after long-duration single side deafness (SSD) is advocated with neuroimaging evidence while little known about the short-duration SSDs. In this case-cohort study, we recruited unilateral sudden sensorineural hearing loss (SSNHL) patients and age-, gender-matched health controls (HC), followed by comprehensive analyses. The primary outcome measures were temporal alterations of varied dynamic functional network connectivity (dFNC) states, neurovascular coupling (NVC) brain region volume at different stages SSNHL. secondary pure-tone audiograms SSNHL before treatment. total 38 (21 [55%] male; mean [standard deviation] age, 45.05 [15.83] years) 44 HC (28 [64%] 43.55 [12.80] enrolled. categorized into subgroups based on time from disease onset to initial magnetic resonance imaging scan: early- (n = 16; 1-6 days), intermediate- 9; 7-13 late- stage 13; 14-30 days) groups. We first identified slow state transitions between dFNC states early-stage SSNHL, then revealed decreased NVC restricted auditory cortex late-stage Finally, a significantly left medial superior frontal gyrus (SFGmed) was observed only in cohort. Furthermore, SFGmed robustly correlated both duration patient prognosis. Our study offered for evolvement structural less than 1 month, which may explain, perspective, why have better therapeutic responses recovery.

Language: Английский

Cerebrovascular Dysfunction in Alzheimer’s Disease and Transgenic Rodent Models DOI Creative Commons
Xing Fang, Fan Fan, Richard J. Roman

et al.

Journal of Experimental Neurology, Journal Year: 2024, Volume and Issue: 5(2), P. 42 - 64

Published: Jan. 1, 2024

Alzheimer’s Disease (AD) and Disease-Related Dementia (ADRD) are the primary causes of dementia that has a devastating effect on quality life is tremendous economic burden healthcare system. The accumulation extracellular beta-amyloid (Aβ) plaques intracellular hyperphosphorylated tau-containing neurofibrillary tangles (NFTs) in brain hallmarks AD. They also thought to be underlying cause inflammation, neurodegeneration, atrophy, cognitive impairments accompany discovery APP, PS1, PS2 mutations increase Aβ production families with early onset familial AD led development numerous transgenic rodent models These have provided new insight into role AD; however, they do not fully replicate pathology patients. Familial patients elevate represent only small fraction In contrast, those late-onset sporadic constitute majority cases. This observation, along failure previous clinical trials targeting or Tau modest success recent using monoclonal antibodies, reappraisal view sole factor pathogenesis More studies established cerebral vascular dysfunction one earliest changes seen AD, 67% candidate genes linked expressed vasculature. Thus, there an increasing appreciation contribution National Institute Aging (NIA) Foundation recently prioritized it as focused research area. review summarizes strengths limitations most commonly used animal current views about versus cerebrovascular

Language: Английский

Citations

5
Circadian and Diurnal Regulation of Cerebral Blood Flow DOI Creative Commons
Alastair J.S. Webb, Elizabeth B. Klerman, Emiri T. Mandeville

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 695 - 710

Published: March 14, 2024

Circadian and diurnal variation in cerebral blood flow directly contributes to the risk of stroke, either through factors that trigger stroke or due impaired compensatory mechanisms. Cerebral results from integration systemic hemodynamics, including heart rate, cardiac output, pressure, with cerebrovascular regulatory mechanisms, reactivity, autoregulation, neurovascular coupling. We review evidence for circadian each these mechanisms their integration, detailed underlying nocturnal nadir morning surge pressure identifying limited available We, thus, identify key hemodynamic related but particularly need further research focused on

Language: Английский

Citations

5
An EEG-fNIRS neurovascular coupling analysis method to investigate cognitive-motor interference DOI
Jianeng Lin, Jiewei Lu, Zhilin Shu

et al.

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 160, P. 106968 - 106968

Published: May 6, 2023

Language: Английский

Citations

11
Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms DOI Creative Commons
Ahmed Faraz Khan, Yasser Iturria‐Medina

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 23, 2024

Language: Английский

Citations

4
Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations DOI
Sana Nasim, Colette A. Bichsel, Anna Pinto

et al.

Angiogenesis, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Language: Английский

Citations

4
Unveiling the Interplay: Neurovascular Coupling, Astrocytes and G Protein-Coupled Receptors in Alzheimer’s Disease DOI Creative Commons

Sanarya Al-Jaf,

Alaa Y. Soliman,

Ahmed F. El‐Yazbi

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(2), P. 271 - 285

Published: Jan. 8, 2025

Astrocytes are a type of glial cell that involved in actively modulating synaptic plasticity, neurotransmitter homeostasis, and neuroinflammatory responses. More importantly, they coordinate neuronal activity cerebral blood flow (CBF) what is known as neurovascular coupling (NVC). NVC an essential mechanism maintains the high energy demand brain requires by supplying continuous rapid supply oxygen nutrients through CBF. Impairment one key events triggers spiral occurrences lead to clinical advancement Alzheimer's disease (AD). It yet be determined molecular manifestations impairment relate to; nonetheless, it believed alterations G protein-coupled receptors (GPCRs) responsible for exacerbating these effects. In this review, we summarize current evidence supporting involvement GPCRs on astrocytes pathophysiology AD. Additionally, propose potential research directions further elucidate underlying mechanisms evaluate feasibility targeting specific therapeutic strategy correct memory impairments associated with

Language: Английский

Citations

0
Multimodal imaging of murine cerebrovascular dynamics induced by transcranial pulse stimulation DOI Creative Commons
Maria Eleni Karakatsani, Daniil Nozdriukhin,

S. Tiemann

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Transcranial pulse stimulation (TPS) is increasingly being investigated as a promising potential treatment for Alzheimer's disease (AD). Although the safety and preliminary clinical efficacy of TPS short pulses have been supported by neuropsychological scores in treated AD patients, its fundamental mechanisms are uncharted. Herein, we used multi-modal preclinical imaging platform combining real-time volumetric optoacoustic tomography, contrast-enhanced magnetic resonance imaging, ex vivo immunofluorescence to comprehensively analyze structural hemodynamic effects induced TPS. Cohorts healthy transgenic mice were imaged during after exposure at various per-pulse energy levels. enhanced microvascular network, whereas blood-brain barrier remained intact following procedure. Notably, higher energies necessary induce changes mice, arguably due their impacted vessels. These findings shed light on cerebrovascular dynamics treatment, hence expected assist improving therapeutic outcomes. ·Transcranial facilitates transcranial wave propagation using avoid tissue heating. ·Preclinical combines (OA) (CE-MRI), ·Blood volume enhancement networks was reproducibly observed with OA stimulation. ·CE-MRI gross pathology further confirmed that brain architecture maintained without (BBB) opening exposure, thus validating ·Higher compared wild-type animals, pathological

Language: Английский

Citations

0
From hypoxic pockets to daily routines: linking brain oxygenation and cognitive resilience DOI Creative Commons
Dian Jiao

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Jan. 29, 2025

The discovery of hypoxic pockets within the cortical regions has transformed understanding cerebral oxygen dynamics, revealing their dual role as both contributors to neuronal adaptation and potential precursors dysfunction. These transient oxygen-deprived microenvironments play a pivotal in neurovascular coupling, synaptic plasticity, angiogenesis, processes crucial for maintaining cognitive resilience health. Investigating is particularly relevant aging populations individuals with neurodegenerative conditions. Concurrently, research underscores ability physical, social, activities modulate brain oxygenation, offering natural, accessible interventions optimize delivery utilization. This study synthesizes findings from neuroimaging, behavioral science, longitudinal studies, illustrating how daily routines can mitigate hypoxia-induced decline promote resilience. By integrating insights centenarians, hypoxia-adapted species, multimodal intervention this framework highlights transformative lifestyle-based strategies addressing deficits. advocate an interdisciplinary approach develop targeted public health, rehabilitation, personalized care.

Language: Английский

Citations

0
Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice DOI Creative Commons
Natarajan Duraipandy,

Shoba Ekambaram,

Stefano Tarantini

et al.

Aging, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Aging | doi:10.18632/aging.206203. Duraipandy Natarajan, Shoba Ekambaram, Stefano Tarantini, Raghavendra Y. Nagaraja, Andriy Yabluchanskiy, Andria F. Hedrick, Vibhudutta Awasthi, Madhan Subramanian, Anna Csiszar, Priya Balasubramanian

Language: Английский

Citations

0
Resting-State Brain Network Characteristics Related to Mild Cognitive Impairment: A Preliminary fNIRS Proof-of-Concept Study DOI Creative Commons
Guohui Yang, Chenhui Fan, Haozheng Li

et al.

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(2)

Published: Jan. 25, 2025

Background: This study investigates the reliability of functional near-infrared spectroscopy (fNIRS) in detecting resting-state brain network characteristics patients with mild cognitive impairment (MCI), focusing on static connectivity (sRSFC) and dynamic (dRSFC) patterns MCI healthy controls (HCs) without impairment. Methods: A total 89 83 HCs were characterized using neuropsychological scales. Subject sRSFC strength dRSFC variability coefficients evaluated via fNIRS. The feasibility fNIRS to measure these metrics compared between two groups. Correlations Montreal Cognitive Assessment (MoCA) scores also explored. Results: homologous networks was significantly lower than heterologous (p < 0.05). significant negative correlation observed at both group individual levels 0.001). While did not differentiate HCs, dorsal attention (DAN) default mode (DMN), ventral (VAN) visual (VIS), emerged as sensitive biomarkers after false discovery rate correction No found MoCA measures. Conclusions: can be used networks, being more for discriminating HCs. DAN-DMN VAN-VIS regions particularly useful identification differences Clinical Trial Registration: ChiCTR2200057281, registered 6 March, 2022; https://www.chictr.org.cn/showproj.html?proj=133808.

Language: Английский

Citations

0