Language network lateralization is reflected throughout the macroscale functional organization of cortex

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 9, 2023

Hemispheric specialization is a fundamental feature of human brain organization. However, it not yet clear to what extent the lateralization specific cognitive processes may be evident throughout broad functional architecture cortex. While majority people exhibit left-hemispheric language dominance, substantial minority population shows reverse lateralization. Using twin and family data from Human Connectome Project, we provide evidence that atypical dominance associated with global shifts in cortical Individuals organization corresponding hemispheric differences macroscale gradients situate discrete large-scale networks along continuous spectrum, extending unimodal through association territories. Analyses reveal both gradient asymmetries are, part, driven by genetic factors. These findings pave way for deeper understanding origins relationships linking population-level variability properties

Language: Английский

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Lesion-symptom Mapping of Acceptability Judgments in Chronic Poststroke Aphasia Reveals the Neurobiological Underpinnings of Receptive Syntax

Journal of Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 36(6), P. 1141 - 1155

Published: Jan. 1, 2024

Abstract Disagreements persist regarding the neural basis of syntactic processing, which has been linked both to inferior frontal and posterior temporal regions brain. One focal point debate concerns role areas in receptive ability, is mostly assessed using sentence comprehension involving complex structures, a task that potentially confounded with working memory. Syntactic acceptability judgments may provide better measure syntax by reducing need use high memory load sentences enabling assessment various types violations. We therefore tested perception grammatical violations people poststroke aphasia (n = 25), along matched controls 16), English errors word order, agreement, or subcategorization. Lesion data were also collected. Control participants performed near ceiling accuracy higher discriminability agreement subcategorization than order; less able discriminate violations, but, on average, paralleled control Lesion-symptom mapping showed correlation between regions, but not regions. argue these results diverge from models holding are amodal core structure building favor posit hierarchical system

Language: Английский

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ROSE: A neurocomputational architecture for syntax

Journal of Neurolinguistics, Journal Year: 2023, Volume and Issue: 70, P. 101180 - 101180

Published: Nov. 21, 2023

Language: Английский

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The neurobiology of sentence production: A narrative review and meta-analysis

Brain and Language, Journal Year: 2025, Volume and Issue: 264, P. 105549 - 105549

Published: Feb. 20, 2025

Although there is a sizeable body of literature on sentence comprehension and processing both in healthy disordered language users, the production remains much more sparse. Linguistic computational descriptions expressive syntactic deficits aphasia are especially rare. In addition, neuroimaging (psycho) linguistic literatures operate largely separately. this paper, I will first lay out theoretical land with regard to psycholinguistic models production. then provide brief narrative overview large-scale meta-analysis as it pertains computation, followed by an attempt integrate findings from functional clinical neuroimaging. Finally, surrounding propose path forward close some existing gaps.

Language: Английский

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Distinct neural correlates of morphosyntactic and thematic comprehension processes in aphasia

Brain Communications, Journal Year: 2025, Volume and Issue: 7(2)

Published: Jan. 1, 2025

Abstract Functional neuroimaging studies in neurotypical subjects correlate sentence comprehension to a left fronto-temporo-parietal network. Recent voxel-based lesion-symptom mapping (VLSM) of aphasia confirm the link between and posterior region including angular gyrus, supra-marginal gyrus postero-superior division temporal lobe but support pre-frontal involvement inconsistently. However, these focus on thematic role assignment without considering morphosyntactic processes. Hence, available VLSM evidence could provide partial view neurofunctional substrate comprehension. In present study, both processes were evaluated systematically same types each participant, more detailed picture Participants (33 patients with post-stroke 90 healthy controls) completed sentence–picture matching task which active passive, declarative reversible sentences paired morphosyntactic, lexical-semantic alternatives. Phonological short-term memory tasks also administered. Aphasic participants selected from an initial pool 70 because they scored below norm foils (n = 18) or morphological 15), within foils. The correlates starkly distinguishable. Pre-frontal areas inferior middle frontal involved directly processing local features only indirectly When damaged, errors always co-occurred errors, probably damage disrupts grammatical roles ultimately that roles. Morphosyntactic not influenced by word order canonicity. contrast, selective reversals linked parietal significantly order, occurring passive than sentences. An area was critical for non-canonical order. comprehension, regions are (at least simple sentences). Temporal Postero-superior retrieving verb argument structure. Parietal assigning morphosyntactically analysed constituents appropriate role, thus serving crucial function re-analysis. Each plays prevailing exclusive processes, interacting other network possibly providing language-specific domain-general resources needed at various stages

Language: Английский

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Grammatical Parallelism in Aphasia: A Lesion-Symptom Mapping Study

Neurobiology of Language, Journal Year: 2023, Volume and Issue: 4(4), P. 550 - 574

Published: Jan. 1, 2023

Abstract Sentence structure, or syntax, is potentially a uniquely creative aspect of the human mind. Neuropsychological experiments in 1970s suggested parallel syntactic production and comprehension deficits agrammatic Broca’s aphasia, thought to result from damage mechanisms area left frontal lobe. This hypothesis was sometimes termed overarching agrammatism, converging with developments linguistic theory concerning central supporting language comprehension. However, evidence an association among receptive deficits, expressive cortex equivocal. In addition, relationship distinct grammatical deficit paragrammatism, syntax has not been assessed. We used lesion-symptom mapping three partially overlapping groups left-hemisphere stroke patients investigate these issues: primary group 53 subjects larger sample sizes (N = 130, 218) that overlapped group. Paragrammatic were significantly associated multiple analyses comprehension, particularly when incorporating lesion volume as covariate, but not. The correlates impaired performance temporal lobe regions, which also implicated inferior middle regions agrammatism. Our results provide strong against agrammatism hypothesis. By contrast, our suggest possibility alternative parallelism rooted paragrammatism system posterior

Language: Английский

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Causal evidence for a coordinated temporal interplay within the language network

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(47)

Published: Nov. 14, 2023

Recent neurobiological models on language suggest that auditory sentence comprehension is supported by a coordinated temporal interplay within left-dominant brain network, including the posterior inferior frontal gyrus (pIFG), superior and sulcus (pSTG/STS), angular (AG). Here, we probed timing causal relevance of between these regions means concurrent transcranial magnetic stimulation electroencephalography (TMS-EEG). Our TMS-EEG experiments reveal region- time-specific evidence for bidirectional information flow from left pSTG/STS to pIFG back during processing. Adapting condition-and-perturb approach, our findings further can be AG in state-dependent manner.

Language: Английский

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Focal Brain Lesions Causing Acquired Amusia Map to a Common Brain Network

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(15), P. e1922232024 - e1922232024

Published: Feb. 29, 2024

Music is a universal human attribute. The study of amusia, neurologic music processing deficit, has increasingly elaborated our view on the neural organization musical brain. However, lesions causing amusia occur in multiple brain locations and often also cause aphasia, leaving distinct networks for unclear. Here, we utilized lesion network mapping to identify these networks. A systematic literature search was carried out all published case reports lesion-induced amusia. reproducibility specificity identified were then tested an independent prospective cohort 97 stroke patients (46 female 51 male) with repeated structural imaging, specifically assessed both perception language abilities. Lesion heterogeneous but connected common regions, including bilateral temporoparietal insular cortices, precentral gyrus, cingulum. In cohort, mapped network, centering right superior temporal cortex clearly from causally associated aphasia. Lesion-induced longitudinal effects circuit confirmed as reduction gray white matter volume, which correlated severity We demonstrate that despite heterogeneity disrupting processing, there network. These results provide evidence substrate differentiating music-related functions language, providing testable target noninvasive stimulation treat

Language: Английский

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Common and distinct patterns underlying different linguistic tasks: multivariate disconnectome symptom mapping in poststroke patients

Cerebral Cortex, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Abstract Numerous studies have been devoted to neural mechanisms of a variety linguistic tasks (e.g. speech comprehension and production). To date, however, whether how the patterns underlying different are similar or differ remains elusive. In this study, we compared 3 mainly concerning production. address this, multivariate regression approaches with lesion/disconnection symptom mapping were applied data from 216 stroke patients damage left hemisphere. The results showed that could predict both poststroke scores production tasks; these exhibited shared regions on temporal pole hemisphere as well unique contributing prediction for each domain. Lower in associated lesions/abnormalities superior gyrus middle gyrus, while lower inferior parietal lobe frontal lobe. These suggested an important role ventral dorsal stream pathways (i.e. supporting dual model) highlighted applicability novel disconnectome-based cognitive neuroscience research.

Language: Английский

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Four dimensions of naturalistic language production in aphasia after stroke

Brain, Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Abstract There is a rich tradition of research on the neuroanatomical correlates spoken language production in aphasia using constrained tasks (e.g., picture naming), which offer controlled insights into distinct processes that govern speech and (i.e., lexical-semantic access, morphosyntactic construction, phonological encoding, motor programming/execution). Yet these do not necessarily reflect everyday use. In contrast, naturalistic (also referred to as connected or discourse) more closely approximates typical processing demands, requiring dynamic integration all aspects language. The brain bases remain relatively unknown, however, part because difficulty deriving features are salient, quantifiable, interpretable relative both speech-language extant literature. present cross-sectional observational study seeks address challenges by leveraging validated comprehensive auditory-perceptual measurement system yields four explanatory dimensions performance—Paraphasia (misselection words sounds), Logopenia (paucity words), Agrammatism (grammatical omissions), Motor (impaired We used this characterize large representative sample individuals with acute post-stroke (n = 118). Scores each were correlated lesion metrics, multivariate associations among regions then explored. Our findings revealed yet overlapping throughout left-hemisphere network. Paraphasia associated primarily posterior regions, spanning dorsal ventral streams, critical for access encoding. anterior stream involved construction planning/execution respectively. Collectively, we view results constituting brain-behavior model aphasia, aligning historical contemporary accounts neurobiology production.

Language: Английский

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