Body as First Teacher: The Role of Rhythmic Visceral Dynamics in Early Cognitive Development

Perspectives on Psychological Science, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 11, 2023

Embodied cognition-the idea that mental states and processes should be understood in relation to one's bodily constitution interactions with the world-remains a controversial topic within cognitive science. Recently, however, increasing interest predictive processing theories among proponents critics of embodiment alike has raised hopes reconciliation. This article sets out appraise unificatory potential processing, focusing particular on embodied formulations active inference. Our analysis suggests most active-inference accounts invoke weak, potentially trivial conceptions embodiment; those making stronger claims do so independently theoretical commitments framework. We argue more compelling version inference can motivated by adopting diachronic perspective way rhythmic physiological activity shapes neural development utero. According this visceral afferent training hypothesis, early-emerging are essential not only for supporting biophysical structures but also configuring architecture entail. Focusing cardiovascular system, we propose three candidate mechanisms through which might operate: (a) activity-dependent neuronal development, (b) periodic signal modeling, (c) oscillatory network coordination.

Language: Английский

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Quantification of Three Neurotransmitters in Cerebrospinal Fluid, Serum and Random Urine using a Robust and Simplified Liquid Chromatography-Tandem Mass Spectrometry Method

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1747, P. 465791 - 465791

Published: Feb. 18, 2025

Language: Английский

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Mass Spectrometric Monitoring of Redox Transformation and Arylation of Tryptophan

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1349, P. 343822 - 343822

Published: Feb. 22, 2025

Language: Английский

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OLFACTORY DYSFUNCTION: AN EARLY INDICATOR OF PARKINSON'S DISEASE

Brain Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 100209 - 100209

Published: March 1, 2025

Language: Английский

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Biological Cognition

Published: Nov. 23, 2022

This Element introduces a biological approach to cognition, which highlights the significance of allostatic regulation and navigation challenges opportunities. It argues that cognition is best understood as juggling act, reflects numerous ongoing attempts minimize disruptions while prioritizing sources information are necessary satisfy social needs; it provides characterization architectural constraints, neurotransmitters, affective states shape visual perception, well regulatory capacities sustain flexible patterns thought behavior.

Language: Английский

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The 5-HT1F receptor as the target of ditans in migraine — from bench to bedside

Nature Reviews Neurology, Journal Year: 2023, Volume and Issue: 19(8), P. 489 - 505

Published: July 12, 2023

Language: Английский

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New insights into the effects of serotonin on Parkinson's disease and depression through its role in the gastrointestinal tract

Spanish Journal of Psychiatry and Mental Health, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Neuropsychiatric and neurodegenerative disorders are frequently associated with gastrointestinal (GI) co-pathologies. Although the central enteric nervous systems (CNS ENS, respectively) have been studied separately, there is increasing interest in factors that may contribute to conditions affecting both systems. There compelling evidence serotonin (5-HT) play an important role several gut–brain disorders. It well known 5-HT essential for development functioning of CNS. However, most body's produced GI tract. A deeper understanding specific effects on provide basis new therapeutic targets. This review summarizes current data focusing ENS motility, particular emphasis novel aspects signaling where CNS comorbidities common, such as Parkinson's disease depressive

Language: Английский

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Impact of dietary fat types on expression levels of dopamine and serotonin transporters in the ileum of broiler chickens

Poultry Science, Journal Year: 2024, Volume and Issue: 103(11), P. 104114 - 104114

Published: July 26, 2024

Various types of dietary fats undergo distinct fermentation processes by gut microbes, potentially leading to the production neurotransmitters that can influence gut. Serotonin and dopamine are recognized with positive effects on function. A broiler chicken trial was conducted evaluate fat protein expression 2 neurotransmitter transporters, (DAT) serotonin (5-HTT). total 560 day-old (Ross 708) male chicks were randomly assigned 7 treatments. The experimental treatments included a basal diet corn-soybean meal (SBM), supplemented 3% various fats: poultry (CON), olive oil (OLIV), fish (FISH), canola (CANO), lard (LARD), coconut (COCO), or flaxseed (FLAX). Bodyweight (BW) feed conversion ratio (FCR) recorded. Ileal tissues aseptically collected determine levels DAT 5-HTT through western blot analysis. In addition, plasma samples analyzed for reactive oxygen metabolites (d-ROM) tests d 55. Results showed type inclusion did not have any detrimental effect growth performance parameters. higher (P < 0.05) in FLAX compared CON 20 55, respectively. Similarly, levels, FLAX, CANO, LARD than However, oxidative stress (d-ROM values) recorded COCO (32.75 Carr U), CANO (29 (25.5 U) (18.5 U; P treatment. These findings suggest incorporating at level has significant potential elevate intestinal without inducing stress.

Language: Английский

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A prospective code for value in the serotonin system

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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One-drop chemosensing of dapoxetine hydrochloride using opto-analysis by multi-channel μPAD decorated silver nanoparticles: introducing a paper-based microfluidic portable device/sensor toward naked-eye pharmaceutical analysis by lab-on-paper technology

RSC Advances, Journal Year: 2024, Volume and Issue: 14(4), P. 2610 - 2620

Published: Jan. 1, 2024

Dapoxetine (DPX) belongs to the selective serotonin reuptake inhibitor (SSRI) class and functions by blocking transporter increasing activity, thereby delaying ejaculation. Therefore, monitoring of concentration DPX in human biofluids is important for clinicians. In this study, application silver nanoparticles with morphology prisms (AgNPrs) sensitive measurement using colorimetric chemosensing spectrophotometric method was investigated. Also, determined real samples spectrophotometry method. Based on obtained results, all detection process assay related morphological reform AgNPrs after it's specific electrostatic covalent interaction as analyte. The UV-vis results indicate that proposed AgNPrs-based system has a wide range linearity (0.01 μM 1 mM) low limit quantification 0.01 urine samples, which suitable clinical analysis drug samples. It point out that, strategy showed inappropriate analytical novelty platform. Finally, optimized microfluidic paper-based device (μPAD) integrated provide time/color estimating analyte portable substrate toward situ on-site biomedical analysis. Interestingly, validation tests appropriate great stability, may facilitate commercialization engineered substrate. For first time, order simple colorimetric/spectrophotometric recognition determination DPX, an pump-less (μPCD) introduced validated real-time According alternative approach therapeutic (TDM) miniaturized cost-beneficial devices.

Language: Английский

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