Characteristic functional connectome related to Post-COVID-19 syndrome

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 29, 2024

Abstract Post-COVID-19 syndrome is a serious complication following SARS-CoV-2 infection, characterized primarily by fatigue and cognitive complaints. Although first metabolic structural imaging alterations in have been identified, their functional consequences remain unknown. Thus, we explored the impact of on connectome brain providing deeper understanding pathophysiological mechanisms. In cross-sectional observational study, resting-state magnetic resonance data 66 patients with after mild infection (mean age 42.3 years, 57 female) healthy controls 42.1 38 mean time seven months acute COVID-19 were analysed using graph theoretical approach. Network features quantified measures including distance, nodal degree, betweenness Katz centrality, compared between both groups. Graph correlated clinical quantifying fatigue, function, affective symptoms sleep disturbances. Alterations mainly found brainstem, olfactory cortex, cingulate thalamus cerebellum average infection. Additionally, strong correlations severity, functioning daytime sleepiness from scales observed. Our study confirms relevance changes as mediating factors for persistent improves our understanding.

Language: Английский

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Long COVID and its association with neurodegenerative diseases: pathogenesis, neuroimaging, and treatment

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: April 4, 2024

Corona Virus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has presented unprecedented challenges to world. Changes after COVID-19 have had a significant impact on patients with neurodegenerative diseases. This study aims explore mechanism of diseases examining main pathways central nervous system infection SARS-CoV-2. Research indicated that chronic inflammation and abnormal immune response are primary factors leading neuronal damage long-term consequences COVID-19. In some patients, concurrent inflammatory leads increased release pro-inflammatory cytokines, which may significantly prognosis. Molecular imaging can accurately assess severity in phase. Furthermore, use FDG-PET is advocated quantify relationship between neuroinflammation psychiatric cognitive symptoms who recovered from Future development should focus aggressive post-infection control targeted therapies target ACE2 receptors, ERK1/2, Ca 2+ .

Language: Английский

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Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies

Revista de Neurología, Journal Year: 2025, Volume and Issue: 79(12)

Published: Jan. 24, 2025

Introduction: Long COVID is defined by National Institute for Health and Care Excellence (NICE) as the set of signs symptoms that develop during or after a SARS-CoV-2 infection continue more than twelve weeks without any alternative diagnosis. One most frequent persistent reported patients verified in neuroimaging studies cognitive dysfunction, due to generalized hypoconnectivity diffuse axonal lesion white matter. Therefore, objectives present review are determine how long functions remain affected explore which beyond three months follow-up up 65 years age previous neuropsychological psychiatric complications. Methods: A systematic was performed using PRISMA criteria 11 articles were included through comprehensive search five different databases: PubMed, Medline, Scopus, WOS ProQuest. The risk bias assessed Newcastle-Ottawa scale. Results: Cognitive problems persist over time improve slowly, although seem agree areas improved significantly one year. remained impaired longest processing speed attention. Conclusions: These alterations cause reduction quality life work capacity manifest need intervention.

Language: Английский

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Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 2, 2023

Background and purpose The coronavirus disease 2019 (COVID-19) has been associated with olfactory dysfunction. persistent symptoms of anosmia or hyposmia were in previous studies the development memory impairment mood disturbances. We aimed to investigate association between chronicity reported dysfunction subjective objective cognitive performance long-COVID patients explore whether their emotional are related cognition. Methods One hundred twenty-eight participants recruited. Reported symptomatology, complaints, anxiety depression trait-anxiety assessed. Subjective complaints disturbances compared among groups as an acute (AOD), (POD), nonexistent (NOD) symptom. Seventy-six volunteers also participated a face-to-face session assess on tests general function verbal declarative memory. Objective AOD, POD, NOD groups. Results similar groups, but score was lower than those no at any time. Participants’ positively symptoms. relationship depressive symptomatology interacted dysfunction, it only occurred without Depressive negatively delayed performance. months elapsed from diagnosis assessment predicted Anxious immediate ability recall information who did not present phase infection. Conclusion Olfactory infection by COVID-19 is deficits tests, self-reported These findings may contribute further understanding neuropsychological aspects long-COVID.

Language: Английский

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Brain diffusion alterations in patients with COVID-19 pathology and neurological manifestations

NeuroImage Clinical, Journal Year: 2023, Volume and Issue: 37, P. 103338 - 103338

Published: Jan. 1, 2023

COVID-19 neurological manifestations have been progressively recognized. Among available MRI techniques, diffusion weighted imaging (DWI) shows promise to study microstructure, inflammation, and edema. Previous DWI studies reported alterations in brain diffusivity patients, as assessed by morphologic evaluation of scans only. The aim this was assess quantify patients with manifestations. 215 (olfactory and/or other disorders) 36 normal controls were compared studied T1-weighted scans. processed a semi-automatic processing procedure specifically developed for the purpose study, Apparent Diffusion Coefficient (ADC) quantified different tissues individual white matter (WM) gray (GM) regions. Differences ADC values between controls, well patient population grouped hospitalization symptoms. (median [IQR] = 52 [42 – 60] years age, 58 % females), 91 hospitalized 26 needed intensive care. 84 had hyposmia/ageusia only, while 131 ones showed disorders. significantly increased WM several GM regions (p < 0.001). correlated time from disease onset 0.05). Hospitalized higher alteration than non-hospitalized all tissues; similarly, disorders those olfactory loss highest cognitive or memory disorder encephalitis meningitis. neither associated duration nor need Current findings suggest potential non-invasive marker neuroinflammation COVID-19, transient nature same. Future longitudinal are confirm our findings.

Language: Английский

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Markers of limbic system damage following SARS-CoV-2 infection

Brain Communications, Journal Year: 2023, Volume and Issue: 5(4)

Published: Jan. 1, 2023

Alterations of the limbic system may be present in chronic phase SARS-CoV-2 infection. Our aim was to study long-term impact this disease on system-related behaviour and its associated brain functional connectivity, according severity respiratory symptoms acute phase. To end, we investigated multimodal emotion recognition abilities 105 patients from Geneva COVID-COG Cohort 223 days average after infection (diagnosed between March 2020 May 2021), dividing them into three groups (severe, moderate or mild) symptom We used multiple regressions partial least squares correlation analyses investigate relationships recognition, olfaction, cognition, neuropsychiatric networks. Six 9 months following infection, exhibited poorer than mild for expressions fear (P = 0.03 corrected), as did severe disgust 0.04 corrected) irritation < 0.01 corrected). In whole cohort, these performances were with decreased episodic memory anosmia, but not depressive symptoms, anxiety post-traumatic stress disorder. Neuroimaging revealed a positive contribution notably cerebellum default mode, somatosensory motor salience/ventral attention These results highlight consequences SARS-Cov-2 at both behavioural neuroimaging levels.

Language: Английский

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Post-COVID-19 Syndrome Comprehensive Assessment: From Clinical Diagnosis to Imaging and Biochemical-Guided Diagnosis and Management

Viruses, Journal Year: 2023, Volume and Issue: 15(2), P. 533 - 533

Published: Feb. 14, 2023

The COVID-19 outbreak was first reported in 2019, causing massive morbidity and mortality. majority of the patients survived developed Post-COVID-19 Syndrome (PC19S) varying severity. Currently, diagnosis PC19S is achieved through history symptomatology that cannot be explained by an alternative diagnosis. However, heavy reliance on subjective reporting prone to errors. Besides, there no unified diagnostic assessment tool classify clinical severity patients. This leads significant difficulties when managing terms public resource utilization, progression monitorization rehabilitation plan formulation. narrative review aims current evidence based triple assessment: symptomatology, biochemical analysis imaging evidence. Further tools can monitor patient’s progression, prognosis intervals monitoring. It also highlights high-risk features for closer earlier Rehabilitation programs related trials are evaluated; however, most them focus cardiorespiratory fitness psychiatric presentations such as anxiety depression. research required establish objective comprehensive facilitate management plans.

Language: Английский

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Transcranial direct current stimulation for post-COVID fatigue: a randomized, double-blind, controlled pilot study

Brain Communications, Journal Year: 2023, Volume and Issue: 5(2)

Published: March 2, 2023

Fatigue is one of the most frequent and disabling symptoms post-COVID syndrome. In this study, we aimed to assess effects transcranial direct current stimulation on fatigue severity in a group patients with syndrome chronic fatigue. We conducted double-blind, parallel-group, sham-controlled study evaluate short-term anodal (2 mA, 20 min/day) left dorsolateral prefrontal cortex. The modified impact scale score was used as primary endpoint. Secondary endpoints included cognition (Stroop test), depressive (Beck depression inventory) quality life (EuroQol-5D). Patients received eight sessions were evaluated at baseline, immediately after last session, month later. Forty-seven enrolled (23 active treatment 24 sham group); mean age 45.66 ± 9.49 years, 37 (78.72%) women. progression time since acute infection 20.68 6.34 months. Active associated statistically significant improvement physical end 1 compared stimulation. No effect detected for cognitive terms secondary outcomes, an treatment. had no life. All adverse events reported mild transient, differences between groups. conclusion, our results suggest that cortex may improve Further studies are needed confirm these findings optimize protocols.

Language: Английский

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Hippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome

EBioMedicine, Journal Year: 2023, Volume and Issue: 94, P. 104711 - 104711

Published: July 13, 2023

Cognitive deficits are among the main disabling symptoms in COVID-19 patients and post-COVID syndrome (PCS). Within brain regions, hippocampus, a key region for cognition, has shown vulnerability to SARS-CoV-2 infection. Therefore, vivo detailed evaluation of hippocampal changes PCS patients, validated on post-mortem samples at acute phase, would shed light into relationship between cognition.Hippocampal subfields volume, microstructure, perfusion were evaluated 84 compared 33 controls. Associations with blood biomarkers, including glial fibrillary acidic protein (GFAP), myelin oligodendrocyte glycoprotein (MOG), eotaxin-1 (CCL11) neurofilament chain (NfL) evaluated. Besides, biomarker immunodetection seven necropsies phase contrasted against eight controls.In analyses revealed that grey matter atrophy is accompanied by altered microstructural integrity, hypoperfusion, functional connectivity patients. Hippocampal structural alterations related cognitive dysfunction, particularly attention memory. GFAP, MOG, CCL11 NfL biomarkers PCS, showed associations volume changes, selective subfields. Moreover, post mortem histology presence increased GFAP reduced MOG concentrations hippocampus phase.The current results evidenced sequalae present cascade pathological indicating axonal damage, astrocyte alterations, neuronal injury, already from phase.Nominative Grant FIBHCSC 2020 COVID-19. Department Health, Community Madrid. Instituto de Salud Carlos III through project INT20/00079, co-funded European Regional Development Fund "A way make Europe" (JAMG). (ISCIII) Sara Borrell postdoctoral fellowship No. CD22/00043) Union (MDC). predoctoral contract (FI20/000145) (co-funded Europe") (MVS). Fundación para el Conocimiento Madri+d G63-HEALTHSTARPLUS-HSP4 (JAMG, SOM).

Language: Английский

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Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model

EBioMedicine, Journal Year: 2024, Volume and Issue: 105, P. 105191 - 105191

Published: June 13, 2024

Coronavirus disease 2019 (COVID-19) frequently leads to neurological complications after recovery from acute infection, with higher prevalence in women. However, mechanisms by which SARS-CoV-2 disrupts brain function remain unclear and treatment strategies are lacking. We previously demonstrated neuroinflammation the olfactory bulb of intranasally infected hamsters, followed alpha-synuclein tau accumulation cortex, thus mirroring pathogenesis neurodegenerative diseases such as Parkinson's or Alzheimer's disease.

Language: Английский

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