Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait DOI Creative Commons

Caiting Gan,

Xingyue Cao,

Lina Wang

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2023, Volume and Issue: 10(5), P. 814 - 824

Published: March 31, 2023

Abstract Background Mounting research support that cholinergic dysfunction plays a prominent role in freezing of gait (FOG), which commonly occurs Parkinson's disease (PD). Basal forebrain (BF), especially the nuclei 4 (Ch4), provides primary source brain input. However, whether degeneration BF and its innervated cortex contribute to pathogenesis FOG is unknown. Objective To explore structural alterations cortical regions PD patients with freezing. Methods Magnetic resonance imaging assessments neurological were performed on 20 (PD‐FOG), without (PD‐NFOG), 21 healthy participants. Subregion volumes compared among groups. Local gyrification index (LGI) was computed reveal alternations. Relationships subregional volumes, LGI, severity evaluated by multiple linear regression. Results Our study discovered that, PD‐NFOG, PD‐FOG exhibited significant Ch4 atrophy ( p = 4.6 × 10 −5 ), accompanied decreased LGI values left entorhinal 3.00 ) parahippocampal gyrus 2.90 ). Based regression analysis, volume negatively associated group β −12.224, T −2.556, 0.031). Interpretation results imply microstructural disorganization may play important roles PD‐FOG.

Language: Английский

Cognitive and Cholinergic Systems Trajectories in Parkinson Disease DOI

Taylor Brown,

Prabesh Kanel,

Giulia Carli

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Cognitive decline in Parkinson disease (PD) is a disabling and highly variable non-motor feature. While cholinergic systems degeneration linked to cognitive impairments PD, most prior research reported cross-sectional associations. We aimed fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ligand [

Language: Английский

Citations

2
Sleep-related Respiratory Disruptions and Laterodorsal Tegmental Nucleus in a Mouse Model of Parkinson’s Disease DOI Creative Commons
Nicole C. Miranda, Luíz M. Oliveira, Thiago S. Moreira

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111251 - 111251

Published: Oct. 24, 2024

Language: Английский

Citations

2
Regional Cerebral Cholinergic Vesicular Transporter Correlates of Visual Contrast Sensitivity in Parkinson’s Disease: Implications for Visual and Cognitive Function DOI

Taylor Brown,

Prabesh Kanel, Alexis Griggs

et al.

Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 131, P. 107229 - 107229

Published: Dec. 9, 2024

Language: Английский

Citations

2
Cholinergic centro-cingulate network in Parkinson disease and normal aging DOI Creative Commons
Nicolaas I. Bohnen, Sygrid van der Zee, Roger L. Albin

et al.

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 27, 2023

Decreased cholinergic binding within the recently identified centro-cingulate brain network robustly has been shown to correlate with severity of cognitive impairment in Parkinson disease (PD). This key hubs cingulum, operculum and peri-central cortical regions also correlates elements parkinsonian motor impairments, including postural instability gait difficulties, such as falls or freezing. MRI neuroimaging studies have that anterior midcingulate cortex is a node for aspects movement generation, i.e., intentional control. Recent evidence suggests novel aspect organization primary cortex, describing “effector” fine control intercalated interlinked “inter-effector” devoted whole-body A distinguishing feature inter-effector tight linkage cingular opercular regions. Such proposed be part greater somato-cognitive action necessary integration goals movement. points vulnerabilities nerve terminals older non-PD adults. These features normal aging underscore terminal losses age-associated neurodegenerative disorders are likely not exclusively result disease-specific etiologies but related otherwise aging. Practical implications this overlap addressing general involved neurodegeneration, may benefit where significant systems degeneration present.

Language: Английский

Citations

5
Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait DOI Creative Commons

Caiting Gan,

Xingyue Cao,

Lina Wang

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2023, Volume and Issue: 10(5), P. 814 - 824

Published: March 31, 2023

Abstract Background Mounting research support that cholinergic dysfunction plays a prominent role in freezing of gait (FOG), which commonly occurs Parkinson's disease (PD). Basal forebrain (BF), especially the nuclei 4 (Ch4), provides primary source brain input. However, whether degeneration BF and its innervated cortex contribute to pathogenesis FOG is unknown. Objective To explore structural alterations cortical regions PD patients with freezing. Methods Magnetic resonance imaging assessments neurological were performed on 20 (PD‐FOG), without (PD‐NFOG), 21 healthy participants. Subregion volumes compared among groups. Local gyrification index (LGI) was computed reveal alternations. Relationships subregional volumes, LGI, severity evaluated by multiple linear regression. Results Our study discovered that, PD‐NFOG, PD‐FOG exhibited significant Ch4 atrophy ( p = 4.6 × 10 −5 ), accompanied decreased LGI values left entorhinal 3.00 ) parahippocampal gyrus 2.90 ). Based regression analysis, volume negatively associated group β −12.224, T −2.556, 0.031). Interpretation results imply microstructural disorganization may play important roles PD‐FOG.

Language: Английский

Citations

4