A cortico-subcortical loop for motor control via the pontine reticular formation DOI Open Access
Emília Bősz, Viktor Plattner, László Bíró

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 12, 2023

Summary Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Inhibitory output of BG loop can directly control movement via specialized connections with brainstem. Whether other parallel loops similar logic exist is presently unclear. Here we demonstrate that glycine transporter 2-positive (GlyT2+) cells pontine reticular formation (PRF) receive cortical inputs in turn innervate thalamus. Thalamus-projecting GlyT2+ subcortical regions distinct from targets. Cortical co-innervate PRF/GlyT2+ thalamus as loops. Cortex exerts strong excitatory on these neurons powerfully inhibit their thalamic Activation projecting leads to contralateral turning. These results PRF part a cortico-subcortical regulates motor activity circuits. The cortico-PRF-thalamus synergistically turning descending pathways. Graphical abstract

Language: Английский

State‐specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal DOI Creative Commons
Zhao Zhang,

Yi‐Chun Huang,

Xiaoyu Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: June 27, 2024

Abstract Long‐range thalamocortical communication is central to anesthesia‐induced loss of consciousness and its reversal. However, isolating the specific neural networks connecting thalamic nuclei with various cortical regions for state‐specific anesthesia regulation challenging, biological underpinnings still largely unknown. Here, simultaneous electroencephalogram‐fuctional magnetic resonance imaging (EEG‐fMRI) deep brain stimulation are applied intralaminar thalamus in macaques under finely‐tuned propofol anesthesia. This approach led identification an intralaminar‐driven network responsible rapid arousal during slow‐wave oscillations. A network‐based RNA‐sequencing analysis conducted region‐, layer‐, cell‐specific gene expression data from independent transcriptomic atlases identifies 2489 genes preferentially expressed within this network, notably enriched potassium channels excitatory, parvalbumin‐expressing neurons, oligodendrocytes. Comparison human highlights conserved molecular cellular architectures that enable matching homologous genes, protein interactions, cell types across primates, providing novel insight into network‐focused transcriptional signatures arousal.

Language: Английский

Citations

2
Deep brain stimulation DOI
Joachim K. Krauss, Johanna Nagel

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 16 - 41

Published: Aug. 7, 2024

Language: Английский

Citations

2
The posterior intralaminar thalamic nucleus promotes nose‐to‐nose contacts leading to prosocial reception in the sequence of mouse social interaction DOI Creative Commons
Hiroyuki Arakawa, Mana Tokashiki

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(7), P. 5731 - 5749

Published: Aug. 29, 2024

Efficient social interaction is essential for an adaptive life and consists of sequential processes multisensory events with counterparts. Social touch/contact a unique component that promotes sequence behaviours initiated by detection approach to assess stimulus subsequent form prosocial relationships. We hypothesized the thalamic sensory relay circuit from posterior intralaminar nucleus thalamus (pIL) paraventricular hypothalamus (PVN) medial amygdala (MeA) plays key role in contact-mediated events. found neurons pIL along PVN MeA were activated encounters activity was more abundant direct physical encounter, whereas dominant indirect through grid encounter. Chemogenetic inhibition selectively decreased investigatory sniffing same-sex, but not opposite-sex, mouse encounter situation facial/snout contact ratio setting. Furthermore, chemogenetic had no impact on anxiety-like or body coordinative motor behaviours, it impaired whisker-related plantar touch tactile sense. propose can sensations mediate nonsexual interactions thus significant establishing relationships models.

Language: Английский

Citations

2
Stereotactic Radiosurgery for Medically Refractory Non-lesional Epilepsy: A Case-Based Radiosurgery Society (RSS) Practice Review DOI
Samuel R Daly, Jose M. Soto,

Sarah Mc Gonzalez

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 246, P. 108550 - 108550

Published: Sept. 11, 2024

Language: Английский

Citations

2
Drug-resistant juvenile myoclonic epilepsy: A literature review DOI
Anca Nica

Revue Neurologique, Journal Year: 2024, Volume and Issue: 180(4), P. 271 - 289

Published: March 8, 2024

Language: Английский

Citations

1
Human intralaminar and medial thalamic nuclei transiently gate conscious perception through the thalamocortical loop DOI Creative Commons
Zepeng Fang, Yuanyuan Dang,

Anan Ping

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Abstract Human high-order thalamic nuclei have been known to closely correlate with conscious states. However, given the great difference of states and contents (conscious perception), it is nearly unknown how those thalamocortical interactions directly contribute transient process perception. To address this question, we simultaneously recorded local field potentials (LFP) in human intralaminar, medial ventral as well prefrontal cortex (PFC), while patients implanted electrodes performing a visual consciousness task. Overall, compared nuclei, intralaminar showed earlier stronger consciousness-related activity. Moreover, neural synchrony cross-frequency coupling were both driven by theta phase during These results indicated that rather than commonly believed PFC, play decisive ‘gate’ role Highlights Intralaminar activity, comparing nuclei. transiently drove synchronization through (2-8Hz) modulation emergence consciousness. Theta activity dynamically regulated amplitude PFC more regulation on lateral other subregions

Language: Английский

Citations

1
Modulation of neuronal activity in human centromedian nucleus during an auditory attention and working memory task DOI Creative Commons
Frhan I. Alanazi, Carlos Restrepo,

Juan Sebastián Saavedra Moreno

et al.

NeuroImage, Journal Year: 2024, Volume and Issue: 296, P. 120686 - 120686

Published: June 12, 2024

Centromedian nucleus (CM) is one of several intralaminar nuclei the thalamus and thought to be involved in consciousness, arousal, attention. CM has been suggested play a key role control attention, by regulating flow information different brain regions such as ascending reticular system, basal ganglia, cortex. While neurophysiology attention visual auditory systems studied animal models, combined single unit LFP recordings human have not, our knowledge, reported. Here, we recorded neuronal activity 11 patients prior insertion deep stimulation electrodes for treatment epilepsy while subjects performed an task. Patients were requested attend count infrequent (p = 0.2) odd or "deviant" tones, ignore frequent standard tones report total number deviant at trial completion. Spikes discriminated, LFPs band pass filtered (5-45 Hz). Average peri‑stimulus time histograms spectra constructed aligning on tone onsets statistically compared. The firing rate neurons showed selective, multi-phasic responses 81% tested neurons. Local field potential analysis selective beta low gamma (13-45 Hz) modulations response also pattern. current study demonstrates that are under top-down participate processing during working memory. These results, taken together, implicate memory support oscillatory cognitive processes. It implications DBS therapy non-motor symptoms PD, apathy other disorders

Language: Английский

Citations

1
The lateral thalamus: a bridge between multisensory processing and naturalistic behaviors DOI
Mingyu Yang, David W. Keller, Árpád Dobolyi

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
Disuse-driven plasticity in the human thalamus and putamen DOI Creative Commons
Roselyne J. Chauvin, Dillan J. Newbold, Ashley N. Nielsen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 8, 2023

Motor adaptation in cortico-striato-thalamo-cortical loops has been studied mainly animals using invasive electrophysiology. Here, we leverage functional neuroimaging humans to study motor circuit plasticity the human subcortex. We employed an experimental paradigm that combined two weeks of upper-extremity immobilization with daily resting-state and task fMRI before, during, after casting period. previously showed limb disuse leads decreased connectivity (FC) contralateral somatomotor cortex (SM1) ipsilateral cortex, increased FC cingulo-opercular network (CON) as well emergence high amplitude, signal pulses localized SM1, supplementary area cerebellum. From our prior observations, it remains unclear whether affects thalamus striatum. extended analysis include these subcortical regions found both exhibit strengthened cortical spontaneous induced by disuse. The dorsal posterior putamen central thalamus, CM, VLP VIM nuclei, changes lined up fmri activations from Human connectome project system localizer, acquired before for each participant. Our findings provide a novel understanding role potential link physiology sleep regulation. Additionally, similarities observation Parkinson Disease (PD) questions pathophysiological

Language: Английский

Citations

3
A unified central thalamus mechanism underlying diverse recoveries in disorders of consciousness DOI Open Access
Haoran Zhang, Qianqian Ge, Xiao Liu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Disorders of consciousness (DoC) encompass a range states characterized by prolonged altered awareness due to heterogeneous brain damage and are associated with highly diverse prognoses. However, the neural mechanisms underlying such recoveries in DoC remain unclear. To address this issue, we analysed neuronal spiking activities recorded from central thalamus (CT), key hub arousal regulation, cohort 23 patients receiving deep stimulation treatment. Using machine learning techniques, identified core set electrophysiological features CT, particularly theta rhythm, that could account for individual recovery outcomes across varied etiologies (trauma, brainstem hemorrhage, anoxia), clinical baselines patient ages. These also correctly one subgroup who exhibited poor initial manifestations but recovered unexpectedly. Simulating conductance-based model further revealed neurodynamics rhythm CT during different stages recovery. Taken together, these findings uncover previously unknown, unified mechanism governs DoC.

Language: Английский

Citations

0