Clinical Science,
Journal Year:
2024,
Volume and Issue:
138(13), P. 777 - 795
Published: June 11, 2024
Abstract
Renal
tubular
injury
is
considered
as
the
main
pathological
feature
of
acute
kidney
(AKI),
and
mitochondrial
dysfunction
in
renal
cells
implicated
pathogenesis
AKI.
The
estrogen-related
receptor
γ
(ERRγ)
a
member
orphan
nuclear
receptors
which
plays
regulatory
role
biosynthesis,
energy
metabolism
many
metabolic
pathways.
Online
datasets
showed
dominant
expression
ERRγ
tubules,
but
AKI
still
unknown.
In
present
study,
we
investigated
therapeutic
efficacy
agonist
DY131
several
murine
models
was
reduced
kidneys
patients
along
with
negative
correlation
to
severity
Consistently,
silencing
vitro
enhanced
cisplatin-induced
apoptosis,
while
overexpression
vivo
utilizing
hydrodynamic-based
tail
vein
plasmid
delivery
approach
alleviated
could
enhance
transcriptional
activity
ameliorate
various
models.
Moreover,
attenuated
disorders
AKI,
promoted
factor
A
(TFAM).
Further
investigation
that
TFAM
be
target
gene
might
by
enhancing
ERRγ-mediated
protecting
mitochondria.
These
findings
highlighted
protective
effect
on
thus
providing
promising
strategy
for
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: Aug. 1, 2024
Abstract
Macrophages
are
versatile
immune
cells
with
remarkable
plasticity,
enabling
them
to
adapt
diverse
tissue
microenvironments
and
perform
various
functions.
Traditionally
categorized
into
classically
activated
(M1)
alternatively
(M2)
phenotypes,
recent
advances
have
revealed
a
spectrum
of
macrophage
activation
states
that
extend
beyond
this
dichotomy.
The
complex
interplay
signaling
pathways,
transcriptional
regulators,
epigenetic
modifications
orchestrates
polarization,
allowing
respond
stimuli
dynamically.
Here,
we
provide
comprehensive
overview
the
cascades
governing
focusing
on
roles
Toll‐like
receptors,
signal
transducer
activator
transcription
proteins,
nuclear
microRNAs.
We
also
discuss
emerging
concepts
metabolic
reprogramming
trained
immunity,
contributing
their
functional
adaptability.
Macrophage
plasticity
plays
pivotal
role
in
repair
regeneration,
macrophages
coordinating
inflammation,
angiogenesis,
matrix
remodeling
restore
homeostasis.
By
harnessing
potential
novel
therapeutic
strategies
targeting
polarization
could
be
developed
for
diseases,
including
chronic
wounds,
fibrotic
disorders,
inflammatory
conditions.
Ultimately,
deeper
understanding
molecular
mechanisms
underpinning
will
pave
way
innovative
regenerative
medicine
engineering
approaches.
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 1, 2025
Abstract
Diabetes
mellitus,
a
pervasive
chronic
metabolic
disorder,
is
often
associated
with
complications
such
as
impaired
wound
healing.
Various
factors,
most
notably
vascular
deficiency,
govern
the
repair
process
in
diabetic
patients,
significantly
impeding
healing;
therefore,
angiogenesis
and
its
role
have
emerged
important
areas
of
research.
This
review
aims
to
delve
into
mechanisms
angiogenesis,
effects
diabetes
on
association
between
repair.
will
ultimately
offer
valuable
guidance
regarding
ideal
timing
treatment
clinical
setting.
Giant,
Journal Year:
2024,
Volume and Issue:
19, P. 100323 - 100323
Published: July 10, 2024
Inspired
by
the
extracellular
matrix
(ECM),
biomaterials
have
emerged
as
promising
strategies
in
biomedical
research
and
engineering
domain,
offering
unique
characteristics
for
tissue
regeneration,
drug
delivery,
therapeutic
interventions,
cellular
investigations.
The
ECM,
a
dynamic
network
structure
secreted
various
cells,
primarily
comprises
diverse
proteins
capable
of
facilitating
tissue-ECM
signaling
regulatory
functions
through
its
rich
array
bioactive
substances
multi-level
structural
properties.
Drawing
inspiration
from
intricate
biochemical
composition
natural
researchers
developed
to
encapsulate
these
features
create
biomimetic
microenvironments,
such
electrospinning,
hydrogels/hydrogel
microspheres,
decellularized
ECM(dECM),
ECM-mimicking
peptides.
Furthermore,
mimicking
ECM
components,
ECM-inspired
exhibit
varying
degrees
functionalization,
including
providing
support,
cell
adhesion,
signal
transduction,
mitigating
immune
responses,
remodeling.
In
summary,
advancements
offer
significant
promise
addressing
key
challenges
fields
engineering,
regenerative
medicine,
delivery.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
Skin
wound
healing
is
a
complicated
biological
process
that
mainly
occurs
in
response
to
injury,
burns,
or
diabetic
ulcers.
It
can
also
be
triggered
by
other
conditions
such
as
dermatitis
and
melanoma-induced
skin
cancer.
Delayed
non-healing
after
injury
presents
an
important
clinical
issue;
therefore,
further
explorations
into
the
occurrence
development
of
at
cellular
molecular
levels
are
necessary.
Single-cell
sequencing
(SCS)
used
sequence
analyze
genetic
messages
single
cell.
Furthermore,
SCS
accurately
detect
cell
expression
gene
sequences.
The
use
technology
has
resulted
emergence
new
concepts
pertaining
healing,
making
it
tool
for
studying
relevant
mechanisms
developing
treatment
strategies.
This
article
discusses
application
value
technology,
effects
latest
research
on
applications.
Using
determine
potential
biomarkers
repair
will
serve
accelerate
reduce
scar
formation,
optimize
drug
delivery,
facilitate
personalized
treatments.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 17, 2025
Skin
repair
and
regeneration
are
crucial
processes
in
restoring
the
integrity
of
skin
after
injury,
with
significant
implications
for
medical
treatments
plastic
surgery.
Multiomics,
an
integrated
approach
combining
genomics,
transcriptomics,
proteomics,
metabolomics,
offers
unprecedented
insights
into
complex
molecular
cellular
mechanisms
involved
healing.
This
review
explores
transformative
role
multiomics
elucidating
regeneration.
While
genomic
studies
identify
genetic
basis
wound
healing,
transcriptomics
proteomics
uncover
dynamic
changes
gene
protein
expression,
metabolomics
provides
a
snapshot
metabolic
alterations
associated
Integrative
can
also
novel
biomarkers
therapeutic
targets
Despite
technical
biological
challenges,
future
research
holds
great
promise
advancing
personalized
medicine
improving
healing
strategies.
Through
interdisciplinary
collaboration,
has
potential
to
revolutionize
our
understanding
repair,
paving
way
innovative
surgery
beyond.
Journal of Oral Pathology and Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
ABSTRACT
Background
Recurrent
aphthous
ulcers
significantly
impact
patients'
quality
of
life
due
to
their
painful
and
recurrent
nature,
necessitating
more
effective
treatments.
This
study
explores
the
therapeutic
potential
Boswellia
treat
by
its
anti‐inflammatory
healing
promotion
effect
in
a
rat
oral
ulcer
model.
Methods
Network
pharmacology
techniques
were
employed
elucidate
Boswellia's
active
components
targets.
Intersecting
targets
ulcer‐related
genes
screened
for
protein–protein
interaction
network
analysis
functional
enrichment.
An
model
rats
was
used
treated
with
extract.
The
process
monitored
measuring
area
body
weight
changes.
Histological
performed,
role
macrophage
polarization
investigated
through
gene
expression
protein
array
tests.
underlying
mechanism
involving
PPARγ
activation
also
explored.
Results
revealed
key
pathways
associated
inflammation
lipid
metabolism,
such
as
MAPK3,
PPARG,
PTGS2.
extract
accelerated
recovered
loss
rats.
examinations
reduced
tissue
swelling
inflammatory
cell
infiltration
groups.
Furthermore,
decreased
M1
presence
while
increasing
M2
macrophage,
indicating
an
inflammation‐resolving
effect.
In
vitro
studies
showed
that
enhanced
M2‐related
pro‐inflammatory
cytokines,
which
is
dependent.
Conclusion
promotes
resolves
inflammation,
primarily
modulation
via
activation.
