Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 6, 2024
Lung
cancer,
particularly
non-small
cell
lung
cancer
(NSCLC),
remains
a
leading
cause
of
cancer-related
deaths,
with
conventional
treatments
offering
limited
effectiveness
in
advanced
stages,
due
to
distant
metastases
and
treatment
resistance.
Recent
advancements
immunotherapy,
specifically
immune
checkpoint
inhibitors
(ICIs),
have
shown
promise,
but
their
efficacy
as
standalone
therapies
are
often
insufficient.
This
has
led
increased
interest
combining
ICIs
radiotherapy,
known
radioimmunotherapy
(iRT),
enhance
outcomes.
review
explores
the
mechanisms
that
underlie
synergy
between
radiotherapy
immunotherapy.
Radiotherapy
can
induce
"abscopal
effect",
eliciting
systemic
responses
reduce
tumor
burdens
outside
treated
area.
It
also
increases
expression
major
histocompatibility
complex
class
I
(MHC-I)
on
cells,
improving
recognition.
Furthermore,
modify
microenvironment
by
inducing
metabolic
reprogramming
bolster
anti-tumor
immunity.
We
discuss
strategies
for
optimizing
iRT,
including
considerations
radiation
doses,
fractionation
schedules,
site
selection,
which
significantly
influence
enhancing
MHC-I
or
promoting
T-cell
infiltration.
Clinical
evidence
supports
iRT
NSCLC
other
cancers,
though
challenges
standardizing
protocols
managing
side
effects
persist.
Overall,
presents
promising
approach
Ongoing
research
into
its
refinement
may
reshape
clinical
practice,
more
effective
personalized
options
patients
cancer.
Further
studies
essential
validate
these
findings
optimize
therapeutic
protocols.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: Aug. 1, 2024
Abstract
Macrophages
are
versatile
immune
cells
with
remarkable
plasticity,
enabling
them
to
adapt
diverse
tissue
microenvironments
and
perform
various
functions.
Traditionally
categorized
into
classically
activated
(M1)
alternatively
(M2)
phenotypes,
recent
advances
have
revealed
a
spectrum
of
macrophage
activation
states
that
extend
beyond
this
dichotomy.
The
complex
interplay
signaling
pathways,
transcriptional
regulators,
epigenetic
modifications
orchestrates
polarization,
allowing
respond
stimuli
dynamically.
Here,
we
provide
comprehensive
overview
the
cascades
governing
focusing
on
roles
Toll‐like
receptors,
signal
transducer
activator
transcription
proteins,
nuclear
microRNAs.
We
also
discuss
emerging
concepts
metabolic
reprogramming
trained
immunity,
contributing
their
functional
adaptability.
Macrophage
plasticity
plays
pivotal
role
in
repair
regeneration,
macrophages
coordinating
inflammation,
angiogenesis,
matrix
remodeling
restore
homeostasis.
By
harnessing
potential
novel
therapeutic
strategies
targeting
polarization
could
be
developed
for
diseases,
including
chronic
wounds,
fibrotic
disorders,
inflammatory
conditions.
Ultimately,
deeper
understanding
molecular
mechanisms
underpinning
will
pave
way
innovative
regenerative
medicine
engineering
approaches.
Giant,
Journal Year:
2024,
Volume and Issue:
19, P. 100323 - 100323
Published: July 10, 2024
Inspired
by
the
extracellular
matrix
(ECM),
biomaterials
have
emerged
as
promising
strategies
in
biomedical
research
and
engineering
domain,
offering
unique
characteristics
for
tissue
regeneration,
drug
delivery,
therapeutic
interventions,
cellular
investigations.
The
ECM,
a
dynamic
network
structure
secreted
various
cells,
primarily
comprises
diverse
proteins
capable
of
facilitating
tissue-ECM
signaling
regulatory
functions
through
its
rich
array
bioactive
substances
multi-level
structural
properties.
Drawing
inspiration
from
intricate
biochemical
composition
natural
researchers
developed
to
encapsulate
these
features
create
biomimetic
microenvironments,
such
electrospinning,
hydrogels/hydrogel
microspheres,
decellularized
ECM(dECM),
ECM-mimicking
peptides.
Furthermore,
mimicking
ECM
components,
ECM-inspired
exhibit
varying
degrees
functionalization,
including
providing
support,
cell
adhesion,
signal
transduction,
mitigating
immune
responses,
remodeling.
In
summary,
advancements
offer
significant
promise
addressing
key
challenges
fields
engineering,
regenerative
medicine,
delivery.
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 1, 2025
Abstract
Diabetes
mellitus,
a
pervasive
chronic
metabolic
disorder,
is
often
associated
with
complications
such
as
impaired
wound
healing.
Various
factors,
most
notably
vascular
deficiency,
govern
the
repair
process
in
diabetic
patients,
significantly
impeding
healing;
therefore,
angiogenesis
and
its
role
have
emerged
important
areas
of
research.
This
review
aims
to
delve
into
mechanisms
angiogenesis,
effects
diabetes
on
association
between
repair.
will
ultimately
offer
valuable
guidance
regarding
ideal
timing
treatment
clinical
setting.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Patients
and
healthcare
systems
face
significant
social
financial
challenges
due
to
the
increasing
number
of
individuals
with
chronic
external
internal
wounds
that
fail
heal.
The
complexity
healing
process
remains
a
serious
health
concern,
despite
effectiveness
conventional
wound
dressings
in
promoting
healing.
Recent
advancements
materials
science
fabrication
techniques
have
led
development
innovative
enhance
To
further
expedite
process,
novel
approaches
such
as
nanoparticles,
3D-printed
dressings,
biomolecule-infused
emerged,
along
cell-based
methods.
Additionally,
gene
therapy
technologies
are
being
harnessed
generate
stem
cell
derivatives
more
functional,
selective,
responsive
than
their
natural
counterparts.
This
review
highlights
potential
biomaterials,
3D
bioprinting,
gene-
therapies
However,
it
also
underscores
necessity
for
research
address
existing
integrate
these
strategies
into
standard
clinical
practice.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
Skin
wound
healing
is
a
complicated
biological
process
that
mainly
occurs
in
response
to
injury,
burns,
or
diabetic
ulcers.
It
can
also
be
triggered
by
other
conditions
such
as
dermatitis
and
melanoma-induced
skin
cancer.
Delayed
non-healing
after
injury
presents
an
important
clinical
issue;
therefore,
further
explorations
into
the
occurrence
development
of
at
cellular
molecular
levels
are
necessary.
Single-cell
sequencing
(SCS)
used
sequence
analyze
genetic
messages
single
cell.
Furthermore,
SCS
accurately
detect
cell
expression
gene
sequences.
The
use
technology
has
resulted
emergence
new
concepts
pertaining
healing,
making
it
tool
for
studying
relevant
mechanisms
developing
treatment
strategies.
This
article
discusses
application
value
technology,
effects
latest
research
on
applications.
Using
determine
potential
biomarkers
repair
will
serve
accelerate
reduce
scar
formation,
optimize
drug
delivery,
facilitate
personalized
treatments.
Journal of Oral Pathology and Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
ABSTRACT
Background
Recurrent
aphthous
ulcers
significantly
impact
patients'
quality
of
life
due
to
their
painful
and
recurrent
nature,
necessitating
more
effective
treatments.
This
study
explores
the
therapeutic
potential
Boswellia
treat
by
its
anti‐inflammatory
healing
promotion
effect
in
a
rat
oral
ulcer
model.
Methods
Network
pharmacology
techniques
were
employed
elucidate
Boswellia's
active
components
targets.
Intersecting
targets
ulcer‐related
genes
screened
for
protein–protein
interaction
network
analysis
functional
enrichment.
An
model
rats
was
used
treated
with
extract.
The
process
monitored
measuring
area
body
weight
changes.
Histological
performed,
role
macrophage
polarization
investigated
through
gene
expression
protein
array
tests.
underlying
mechanism
involving
PPARγ
activation
also
explored.
Results
revealed
key
pathways
associated
inflammation
lipid
metabolism,
such
as
MAPK3,
PPARG,
PTGS2.
extract
accelerated
recovered
loss
rats.
examinations
reduced
tissue
swelling
inflammatory
cell
infiltration
groups.
Furthermore,
decreased
M1
presence
while
increasing
M2
macrophage,
indicating
an
inflammation‐resolving
effect.
In
vitro
studies
showed
that
enhanced
M2‐related
pro‐inflammatory
cytokines,
which
is
dependent.
Conclusion
promotes
resolves
inflammation,
primarily
modulation
via
activation.
