Intracellular Porphyromonas gingivalis Promotes the Tumorigenic Behavior of Pancreatic Carcinoma Cells DOI Open Access

Gnanasekaran JebaMercy,

Adi Binder Gallimidi,

Elias S. Saba

et al.

Cancers, Journal Year: 2020, Volume and Issue: 12(8), P. 2331 - 2331

Published: Aug. 18, 2020

Porphyromonas gingivalis is a member of the dysbiotic oral microbiome associated with inflammation and periodontal disease. Intriguingly, epidemiological studies link P. to an increased risk pancreatic cancer. Given that bacteria are detected in human cancer, both mouse pancreata harbor microbiota, we explored involvement tumorigenesis using cell lines xenograft model. Live induced proliferation cancer cells; however, surprisingly, this effect was independent Toll-like receptor 2, innate immune engaged response on other cells, required for induce alveolar bone resorption. Instead, found survives inside trait can be enhanced vitro by hypoxia, central characteristic Increased tumor related degree intracellular persistence, infection cells led growth vivo. To best our knowledge, study first demonstrate direct exposure tumorigenic behavior lines. Our findings shed light potential mechanisms underlying cancer-periodontitis link.

Language: Английский

Pancreatic cancer: A review of epidemiology, trend, and risk factors DOI Creative Commons

Jian-Xiong Hu,

Chengfei Zhao,

Chen WenBiao

et al.

World Journal of Gastroenterology, Journal Year: 2021, Volume and Issue: 27(27), P. 4298 - 4321

Published: July 19, 2021

Despite rapid advances in modern medical technology and significant improvements survival rates of many cancers, pancreatic cancer is still a highly lethal gastrointestinal with low 5-year rate difficulty early detection. At present, the incidence mortality are increasing year by worldwide, no matter United States, Europe, Japan, or China. Globally, projected to increase 18.6 per 100000 2050, average annual growth 1.1%, meaning that will pose public health burden. Due special anatomical location pancreas, development usually diagnosed at late stage obvious clinical symptoms. Therefore, comprehensive understanding risk factors for great significance effective prevention cancer. In this paper, epidemiological characteristics, developmental trends, reviewed analyzed detail.

Language: Английский

Citations

390
Role of microbiota-derived short-chain fatty acids in cancer development and prevention DOI Open Access
Rasoul Mirzaei, Azam Afaghi, Sajad Babakhani

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 139, P. 111619 - 111619

Published: April 24, 2021

Following cancer, cells in a particular tissue can no longer respond to the factors involved controlling cell survival, differentiation, proliferation, and death. In recent years, it has been indicated that alterations gut microbiota components, intestinal epithelium, host immune system are associated with cancer incidence. Also, demonstrated short-chain fatty acids (SCFAs) generated by vitally crucial homeostasis as they contribute modulation of histone deacetylases (HDACs), resulting effected attachment, immigration, cytokine production, chemotaxis, programmed Therefore, manipulation SCFA levels tract structure be potentially taken into consideration for treatment/prevention. current study, we will explain most findings on detrimental or protective roles SFCA (particularly butyrate, propionate, acetate) several cancers, including bladder, colon, breast, stomach, liver, lung, pancreas, prostate cancers.

Language: Английский

Citations

294
Microbiota in pancreatic health and disease: the next frontier in microbiome research DOI
Ryan M. Thomas, Christian Jobin

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 17(1), P. 53 - 64

Published: Dec. 6, 2019

Language: Английский

Citations

258
Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome DOI Creative Commons
Ziying Zhang,

Haosheng Tang,

Peng Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Oct. 11, 2019

Abstract The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects host pathophysiology. Remarkable progress large-scale sequencing mass spectrometry has increased our understanding influence and/or its metabolites onset progression extraintestinal cancers efficacy cancer immunotherapy. Given plasticity microbial composition function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, probiotics, as well fecal transplantation, potentially permit development novel strategies for therapy improve clinical outcomes. Herein, we summarize latest evidence involvement immunity metabolism, effects immune response, modulate microbiome, discuss ongoing studies future areas research that deserve focused efforts.

Language: Английский

Citations

209
The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View DOI Creative Commons
João B. Xavier, Vincent B. Young,

Joseph D. Skufca

et al.

Trends in cancer, Journal Year: 2020, Volume and Issue: 6(3), P. 192 - 204

Published: Feb. 7, 2020

The collection of microbes that live in and on the human body - microbiome can impact cancer initiation, progression, response to therapy, including immunotherapy. mechanisms by which microbiomes cancers yield new diagnostics treatments, but much remains unknown. interactions between microbes, diet, host factors, drugs, cell-cell within itself likely involve intricate feedbacks, no single component explain all behavior system. Understanding role host-associated microbial communities systems will require a multidisciplinary approach combining ecology, immunology, cell biology, computational biology approach.

Language: Английский

Citations

201
A faecal microbiota signature with high specificity for pancreatic cancer DOI Creative Commons
Ece Kartal, Thomas Schmidt, Esther Molina‐Montes

et al.

Gut, Journal Year: 2022, Volume and Issue: 71(7), P. 1359 - 1372

Published: March 8, 2022

Recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression.To explore faecal salivary microbiota as potential diagnostic biomarkers.We applied shotgun metagenomic 16S rRNA amplicon sequencing to samples from Spanish case-control study (n=136), including 57 cases, 50 controls, 29 patients with chronic pancreatitis discovery phase, German (n=76), validation phase.Faecal classifiers performed much better than saliva-based identified PDAC an accuracy of up 0.84 area under receiver operating characteristic curve (AUROC) based on set 27 microbial species, consistent across early late disease stages. Performance further improved 0.94 AUROC when we combined our microbiome-based predictions serum levels carbohydrate antigen (CA) 19-9, only current non-invasive, Food Drug Administration approved, low specificity biomarker. Furthermore, microbiota-based classification model confined PDAC-enriched species was highly disease-specific validated against 25 publicly available populations various health conditions (n=5792). Both models had high prediction population (n=76). Several marker were detectable tumour non-tumour tissue using fluorescence situ hybridisation.Taken together, results indicate that robust specific screening detection is feasible.

Language: Английский

Citations

193
Regulation and modulation of antitumor immunity in pancreatic cancer DOI
Joshua Leinwand, George Miller

Nature Immunology, Journal Year: 2020, Volume and Issue: 21(10), P. 1152 - 1159

Published: Aug. 17, 2020

Language: Английский

Citations

168
Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer DOI Open Access

Se-Young Park,

Byeong-Oh Hwang,

Mihwa Lim

et al.

Cancers, Journal Year: 2021, Volume and Issue: 13(9), P. 2124 - 2124

Published: April 28, 2021

It is well-known that microbiota dysbiosis closely associated with numerous diseases in the human body. The oral cavity and gut are two largest microbial habitats, playing a major role microbiome-associated diseases. Even though continuous regions connected through gastrointestinal tract, microbiome profiles well-segregated due to oral-gut barrier. However, can translocate intestinal mucosa conditions of barrier dysfunction. Inversely, gut-to-oral transmission occurs as well inter- intrapersonal manners. Recently, it has been reported microbiomes interdependently regulate physiological functions pathological processes. Oral-to-gut transmissions shape and/or reshape ecosystem both eventually modulating pathogenesis disease. interaction underappreciated date. Here, we will highlight crosstalk its implications disease cancer. Better understanding axis be advantageous for precise diagnosis/prognosis effective treatment.

Language: Английский

Citations

157
New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries DOI Creative Commons
Tejeshwar Jain, Prateek Sharma,

Abhi C. Are

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 23, 2021

The past decade has witnessed groundbreaking advances in the field of microbiome research. An area where immense implications have been demonstrated is tumor biology. affects initiation and progression through direct effects on cells indirectly manipulation immune system. It can also determine response to cancer therapies predict disease survival. Modulation be harnessed potentiate efficacy immunotherapies decrease their toxicity. In this review, we comprehensively dissect recent evidence regarding interaction anti-tumor machinery outline critical questions which need addressed as further explore dynamic colloquy.

Language: Английский

Citations

132
High fat diet, gut microbiome and gastrointestinal cancer DOI
Yao Tong,

Huiru Gao,

Qiuchen Qi

et al.

Theranostics, Journal Year: 2021, Volume and Issue: 11(12), P. 5889 - 5910

Published: Jan. 1, 2021

Gastrointestinal cancer is currently one of the main causes death, with a large number cases and wide range lesioned sites. A high fat diet, as public health problem, has been shown to be correlated various digestive system diseases tumors, can accelerate occurrence due inflammation altered metabolism. The gut microbiome focus research in recent years, associated cell damage or tumor immune microenvironment changes via direct extra-intestinal effects; this may facilitate development gastrointestinal tumors. Based on showing that both diet microbes promote imbalances intestinal microbes, we propose drives tumors by changing composition microbes.

Language: Английский

Citations

131