Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018)

Clinical Neurophysiology, Journal Year: 2020, Volume and Issue: 131(2), P. 474 - 528

Published: Jan. 1, 2020

A group of European experts reappraised the guidelines on therapeutic efficacy repetitive transcranial magnetic stimulation (rTMS) previously published in 2014 [Lefaucheur et al., Clin Neurophysiol 2014;125:2150–206]. These updated recommendations take into account all rTMS publications, including data prior to 2014, as well currently reviewed literature until end 2018. Level evidence (definite efficacy) was reached for: high-frequency (HF) primary motor cortex (M1) contralateral painful side for neuropathic pain; HF-rTMS left dorsolateral prefrontal (DLPFC) using a figure-of-8 or H1-coil depression; low-frequency (LF) contralesional M1 hand recovery post-acute stage stroke. B (probable DLPFC improving quality life pain, respectively, fibromyalgia; bilateral regions impairment depression, Parkinson's disease; ipsilesional promoting at stroke; intermittent theta burst targeted leg lower limb spasticity multiple sclerosis; right posttraumatic stress disorder; LF-rTMS inferior frontal gyrus chronic post-stroke non-fluent aphasia; and bihemispheric combining right-sided (or continuous stimulation) left-sided depression. A/B is not concerning any other condition. The current are based differences real vs. sham protocols, replicated sufficient number independent studies. This does mean that benefit produced by inevitably reaches level clinical relevance.

Language: Английский

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Recovery from stroke: current concepts and future perspectives

Neurological Research and Practice, Journal Year: 2020, Volume and Issue: 2(1)

Published: June 16, 2020

Abstract Stroke is a leading cause of acquired, permanent disability worldwide. Although the treatment acute stroke has been improved considerably, majority patients to date are left disabled with considerable impact on functional independence and quality life. As absolute number survivors likely further increase due demographic changes in our aging societies, new strategies needed order improve neurorehabilitation. The most critical driver recovery post-stroke neural reorganization. For developing novel, neurobiologically informed promote function, an understanding mechanisms enabling plasticity mandatory. This review provides comprehensive survey recent developments field using neuroimaging non-invasive brain stimulation. We discuss current concepts how reorganizes its architecture overcome stroke-induced deficits, also present evidence for maladaptive effects interfering recovery. demonstrate that combination neurostimulation techniques allows better can be modulated reorganization networks. Finally, neurotechnology-based allowing patient-tailored interventions achieve enhanced responses discussed. highlights important limitations models, finally closes possible solutions future directions.

Language: Английский

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Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation

Frontiers in Cellular Neuroscience, Journal Year: 2017, Volume and Issue: 11

Published: March 15, 2017

Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration function. A better understanding this plastic remodeling crucial develop more effective strategies for stroke rehabilitation. In review, we discuss advances in comprehension post-stroke network patients animal models. We first focus on rodent studies that have shed light mechanisms underlying neuronal perilesional area contralesional hemisphere after motor cortex infarcts. Analysis electrophysiological data has demonstrated brain-wide alterations functional connectivity both hemispheres, well beyond infarcted area. then illustrate potential use non-invasive stimulation techniques boost recovery. finally rehabilitative protocols based robotic devices as a tool promote endogenous plasticity restoration.

Language: Английский

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Brain networks and their relevance for stroke rehabilitation

Clinical Neurophysiology, Journal Year: 2019, Volume and Issue: 130(7), P. 1098 - 1124

Published: April 15, 2019

Language: Английский

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Effects of repetitive transcranial magnetic stimulation on resting-state connectivity: A systematic review

NeuroImage, Journal Year: 2020, Volume and Issue: 211, P. 116596 - 116596

Published: Jan. 31, 2020

The brain is organized into networks that reorganize dynamically in response to cognitive demands and exogenous stimuli. In recent years, repetitive transcranial magnetic stimulation (rTMS) has gained increasing use as a noninvasive means modulate cortical physiology, with effects both proximal the site distal areas are intrinsically connected target. light of these network-level neuromodulatory effects, there been rapid growth studies attempting leverage information about network connectivity improve control intervention outcomes. However, mechanisms-of-action rTMS on remain poorly understood based primarily heuristics from findings. To help bridge this gap, current paper presents systematic review 33 baseline post-rTMS measures fMRI resting-state functional (RSFC). Literature synthesis revealed variability across parameters, studied populations, analysis methodology. Despite variability, it observed active induces significant changes RSFC, but prevalent low-frequency-inhibition/high-frequency-facilitation heuristic endorsed for does not fully describe This also points towards other important considerations, including majority rTMS-induced were found outside stimulated network, suggesting tend spread networks. Future may therefore wish adopt conventions frameworks, such Yeo parcellation atlas adopted here, better characterize effect contribute efficacy rapidly developing interventions.

Language: Английский

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Effects of transcranial magnetic stimulation in modulating cortical excitability in patients with stroke: a systematic review and meta-analysis

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2022, Volume and Issue: 19(1)

Published: Feb. 22, 2022

Abstract Background Transcranial magnetic stimulation (TMS) has attracted plenty of attention as it been proved to be effective in facilitating motor recovery patients with stroke. The aim this study was systematically review the effects repetitive TMS (rTMS) and theta burst (TBS) protocols modulating cortical excitability after Methods A literature search carried out using PubMed, Medline, EMBASE, CINAHL, PEDro, identify studies that investigated four rTMS protocols—low high frequency rTMS, intermittent continuous TBS, on measures random-effects model used for all meta-analyses. Results Sixty-one were included current review. Low decreasing individuals’ resting threshold increasing motor-evoked potential non-stimulated M1 (affected M1), while opposite occurred stimulated (unaffected M1). High enhanced affected alone. Intermittent TBS also showed superior rebalancing bilateral through within unaffected M1, respectively. Due limited number found, remained inconclusive. Motor impairment significantly correlated various forms measures. Conclusions Except is evident these are Current evidence does support inhibitory enhancing M1.

Language: Английский

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The Use of Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation: A Systematic Review

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2017, Volume and Issue: 27(1), P. 1 - 31

Published: Oct. 27, 2017

Language: Английский

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Brain connectivity and neurological disorders after stroke

Current Opinion in Neurology, Journal Year: 2016, Volume and Issue: 29(6), P. 706 - 713

Published: Oct. 5, 2016

Purpose of review An important challenge in neurology is identifying the neural mechanisms underlying behavioral deficits after brain injury. Here, we recent advances understanding effects focal lesions on networks and behavior. Recent findings Neuroimaging studies indicate that human organized large-scale resting state (RSNs) defined via functional connectivity, temporal correlation spontaneous activity between different areas. Prior showed lesion induced behaviorally relevant changes connectivity beyond site damage. work indicates across domains, largely conform to two patterns: a reduction interhemispheric an increase intrahemispheric are normally anticorrelated, for example dorsal attention default networks. Abnormal can exhibit high degree specificity such given domain selectively related corresponding RSN, but some allow prediction domains. Finally, as recovery proceeds, prestroke pattern restored. Summary Investigating RSNs may shed light dysfunction stroke. Therefore, represent tool clinical diagnosis, tracking rehabilitation.

Language: Английский

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Human brain connectivity: Clinical applications for clinical neurophysiology

Clinical Neurophysiology, Journal Year: 2020, Volume and Issue: 131(7), P. 1621 - 1651

Published: April 22, 2020

Language: Английский

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Acute ischaemic stroke alters the brain’s preference for distinct dynamic connectivity states

Brain, Journal Year: 2020, Volume and Issue: 143(5), P. 1525 - 1540

Published: March 14, 2020

Abstract Acute ischaemic stroke disturbs healthy brain organization, prompting subsequent plasticity and reorganization to compensate for the loss of specialized neural tissue function. Static resting state functional MRI studies have already furthered our understanding cerebral by estimating stroke-induced changes in network connectivity aggregated over duration several minutes. In this study, we used dynamic analyses increase temporal resolution seconds explore transient configurations motor acute stroke. To end, collected data 31 patients with 17 age-matched control subjects. Stroke presented moderate severe hand deficits. By within a sliding window framework, identified three distinct motor-related networks. Motor networks were organized into regional domains, i.e. cortical, subcortical cerebellar domain. The patterns diverged from those controls depending on severity initial impairment. Moderately affected (n = 18) spent significantly more time weakly connected configuration that was characterized low levels connectivity, both locally as well between distant regions. contrast, severely 13) showed significant preference transitions spatially segregated configuration. This featured particularly high local domains anti-correlated across domains. A third represented an intermediate pattern compared preceding two, predominantly encompassed decreased interhemispheric cortical independent individual deficit severity. Alterations thus closely resembled previously reported ones originating static post-stroke. summary, not only prompted networks, but it also caused characteristic properties large-scale interactions deficit. These findings offer new vistas mechanisms underlying neurological symptoms, treatment effects patients.

Language: Английский

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