Attitudes Toward COVID-19 Vaccines Among Pregnant and Recently Pregnant Individuals DOI Creative Commons
Joshua T.B. Williams,

Kate Kurlandsky,

Kristin Breslin

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(4), P. e245479 - e245479

Published: April 8, 2024

Importance Pregnant people and infants are at high risk of severe COVID-19 outcomes. Understanding changes in attitudes toward vaccines among pregnant recently is important for public health messaging. Objective To assess attitudinal trends regarding by (1) vaccination status (2) race, ethnicity, language samples Vaccine Safety Datalink (VSD) members from 2021 to 2023. Design, Setting, Participants This cross-sectional surveye study included or the VSD, a collaboration 13 care systems US Centers Disease Control Prevention. Unvaccinated, non-Hispanic Black, Spanish-speaking were oversampled. Wave 1 took place October February 2022, wave 2 November 2022 Data analyzed May September Exposures Self-reported electronic record (EHR)–derived preferred language. Main Outcomes Measures monovalent (wave 1) bivalent Omicron booster 2) vaccines. Sample- response-weighted analyses assessed 3 groupings interest. Results There 1227 respondents; all identified as female, mean (SD) age was 31.7 (5.6) years, 356 (29.0%) Black 555 (45.2%) Hispanic 445 (36.3%) Spanish Response rates 43.5% (652 1500 individuals sampled) 39.5% (575 1456 sampled). Respondents more likely than nonrespondents be White, non-Hispanic, vaccinated per EHR. Overall, 76.8% (95% CI, 71.5%-82.2%) reported vaccinations; respondents had highest weighted proportion with vaccination. Weighted estimates somewhat strongly agreeing that safe decreased who vaccinations (76% vs 50%; χ = 7.8; P < .001), White (72% 43%; 5.4; .02), 53%; 22.8; .002). Conclusions Relevance Decreasing confidence vaccine safety large, diverse insured population concern.

Language: Английский

Risk for Stillbirth Among Women With and Without COVID-19 at Delivery Hospitalization — United States, March 2020–September 2021 DOI Open Access
Carla L. DeSisto, Bailey Wallace, Regina M. Simeone

et al.

MMWR Morbidity and Mortality Weekly Report, Journal Year: 2021, Volume and Issue: 70(47), P. 1640 - 1645

Published: Nov. 19, 2021

Pregnant women are at increased risk for severe COVID-19-related illness, and COVID-19 is associated with an adverse pregnancy outcomes maternal neonatal complications (1-3). To date, studies assessing whether during stillbirth have yielded mixed results (2-4). Since the B.1.617.2 (Delta) variant of SARS-CoV-2 (the virus that causes COVID-19) became predominant circulating variant,* there been anecdotal reports increasing rates stillbirths in COVID-19.† CDC used Premier Healthcare Database Special Release (PHD-SR), a large hospital-based administrative database,§ to assess diagnosis documented delivery hospitalization was March 2020-September 2021 as well before period Delta predominance United States (March 2020-June July-September 2021, respectively). Among 1,249,634 deliveries were rare (8,154; 0.65%): 273 (1.26%) occurred among 21,653 hospitalization, 7,881 (0.64%) 1,227,981 without COVID-19. The adjusted higher compared (adjusted relative [aRR] = 1.90; 95% CI 1.69-2.15), including pre-Delta (aRR 1.47; 1.27-1.71) periods 4.04; 3.28-4.97). stillbirth, stronger association predominance. Implementing evidence-based prevention strategies, vaccination or pregnancy, critical reducing impact on stillbirths.

Language: Английский

Citations

278
Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy DOI Open Access
Elyse O. Kharbanda,

Jacob L. Haapala,

Malini B. DeSilva

et al.

JAMA, Journal Year: 2021, Volume and Issue: 326(16), P. 1629 - 1629

Published: Sept. 8, 2021

Ai-ris Y. Collier, MD; Katherine McMahan, MS; Jingyou Yu, PhD; Lisa H. Tostanoski, Ricardo Aguayo, BS; Jessica Ansel, NP; Abishek Chandrashekar, Shivani Patel, BA; Esther Apraku Bondzie, Daniel Sellers, Julia Barrett, Owen Sanborn, Huahua Wan, Aiquan Chang, Tochi Anioke, Joseph Nkolola, Connor Bradshaw, Catherine Jacob-Dolan, Jared Feldman, Makda Gebre, MSc; Erica N. Borducchi, Jinyan Liu, Aaron G. Schmidt, Todd Suscovich, Caitlyn Linde, Galit Alter, Michele R. Hacker, ScD; Dan Barouch, MD, PhD

Language: Английский

Citations

185
Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer DOI Creative Commons
Konner Cool, Natasha N. Gaudreault, Igor Morozov

et al.

Emerging Microbes & Infections, Journal Year: 2021, Volume and Issue: 11(1), P. 95 - 112

Published: Nov. 29, 2021

SARS-CoV-2 was first reported circulating in human populations December 2019 and has since become a global pandemic. Recent history involving SARS-like coronavirus outbreaks have demonstrated the significant role of intermediate hosts viral maintenance transmission. Evidence natural infection experimental infections wide variety animal species been demonstrated,

Language: Английский

Citations

106
Evaluation of pregnancy outcomes in mothers with COVID-19 infection: a systematic review and meta-analysis DOI Creative Commons
Masoumeh Simbar, Sima Nazarpour, Ali Sheidaei

et al.

Journal of Obstetrics and Gynaecology, Journal Year: 2023, Volume and Issue: 43(1)

Published: Jan. 18, 2023

Pregnant women are one of the endangered groups who need special attention in COVID-19 epidemic. We conducted a systematic review and summarised studies that reported adverse pregnancy outcomes pregnant with infection. A literature search was performed PubMed Scopus up to 1 September 2022, for retrieving original articles published English language assessing association between infection outcomes. Finally, this study, 1790 obtained initial search, 141 eligible including 1,843,278 were reviewed. also meta-analysis total 74 cohort case-control studies. In meta-analysis, both fixed random effect models used. Publication bias assessed by Egger's test trim fill method case significant result, adjust bias. The result showed pooled prevalence preterm delivery, maternal mortality, NICU admission neonatal death group significantly more than those without (p<.01). meta-regression using income level countries. during may cause death. Pregnancy loss SARS-CoV2 positive neonates Lower middle higher High income. Vertical transmission from mother foetus occur, but its immediate long-term effects on newborn unclear.

Language: Английский

Citations

49
Pharmacological treatment of COVID-19: an opinion paper DOI Creative Commons
Alberto García‐Lledó, Javier Gómez‐Pavón, Juan González del Castillo

et al.

Revista Española de Quimioterapia, Journal Year: 2021, Volume and Issue: 35(2), P. 115 - 130

Published: Dec. 11, 2021

The precocity and efficacy of the vaccines developed so far against COVID-19 has been most significant saving advance pandemic. development not prevented, during whole period pandemic, constant search for therapeutic medicines, both among existing drugs with different indications in new drugs. Scientific Committee Illustrious College Physicians Madrid wanted to offer an early, simplified critical approach these drugs, developments immunotherapy what learned from immune response modulators already known which have proven effective virus, order help understand current situation.

Language: Английский

Citations

62
Perinatal Complications in Individuals in California With or Without SARS-CoV-2 Infection During Pregnancy DOI Open Access
Assiamira Ferrara, Monique M. Hedderson, Yeyi Zhu

et al.

JAMA Internal Medicine, Journal Year: 2022, Volume and Issue: 182(5), P. 503 - 503

Published: March 21, 2022

Importance

Additional research from population-based studies is needed to inform the treatment of SARS-CoV-2 infection during pregnancy and provide health risk information pregnant individuals.

Objective

To assess perinatal complications associated with describe factors hospitalizations.

Design, Setting, Participants

This cohort study included 43 886 individuals longitudinal electronic record data preconception delivery who delivered at Kaiser Permanente Northern California between March 1, 2020, 16, 2021. Individuals diagnostic codes for COVID-19 that did not have a confirmatory polymerase chain reaction test were excluded.

Exposures

detected by (from 30 days before conception 7 after delivery) as time varying exposure.

Main Outcomes Measures

Severe maternal morbidity including 21 conditions (eg, acute myocardial infarction, renal failure, respiratory distress syndrome, sepsis) occurred any or delivery; preterm birth; hypertensive disorders; gestational diabetes; venous thromboembolism (VTE); stillbirth; cesarean newborn birth weight conditions. Standardized mean differences without calculated. Cox proportional hazards regression was used estimate hazard ratios (HRs) 95% CIs association hospitalization consider timing relative outcomes.

Results

In this (mean [SD] age, 30.7 [5.2] years), (1332 [3.0%]) more likely be younger, Hispanic, multiparous higher neighborhood deprivation index obesity chronic hypertension. After adjusting demographic characteristics, comorbidities, smoking status, had severe (HR, 2.45; CI, 1.91-3.13), (<37 weeks; HR, 2.08; 1.75-2.47), VTE 3.08; 1.09-8.74) than SARS-CoV-2. also increased medically indicated 2.56; 2.06-3.19); spontaneous 1.61; 1.22-2.13); early 2.52; 1.49-4.24), moderate 2.18; 1.25-3.80), late 1.95; 1.61-2.37) birth. Among infection, 76 (5.7%) hospitalization; pregestational diabetes 7.03; 2.22-22.2) Asian Pacific Islander 2.33; 1.06-5.11) Black 3.14; 1.24-7.93) race ethnicity an hospitalization.

Conclusions Relevance

study, morbidity, birth, VTE. The findings clinicians patients about in support vaccination those planning conception.

Language: Английский

Citations

59
The association between pregnancy and COVID-19: A systematic review and meta-analysis DOI Open Access
Hao Wang, Ning Li, Chenyu Sun

et al.

The American Journal of Emergency Medicine, Journal Year: 2022, Volume and Issue: 56, P. 188 - 195

Published: April 6, 2022

Language: Английский

Citations

59
Diagnosis and management of covid-19 in pregnancy DOI Open Access
Melanie Nana, Kenneth Hodson,

Nuala Lucas

et al.

BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e069739 - e069739

Published: April 26, 2022

Abstract Pregnant women with covid-19 are at greater risk of severe disease than their non-pregnant peers, and yet they frequently denied investigations or treatments because unfounded concerns about to the fetus. The basic principles diagnosing managing same as for patients, a multidisciplinary, expert team approach is essential ensure optimal care. During pregnancy, treatment corticosteroids should be modified use non-fluorinated glucocorticoids. Il-6 inhibitors monoclonal antibodies, together specific antiviral therapies, may also considered. Prophylaxis against venous thromboembolism important. Women require respiratory support oxygen, non-invasive ventilation, ventilation in prone position (either awake during invasive ventilation), intubation extracorporeal membrane oxygenation (ECMO). Pregnancy not contraindication any these supportive criteria providing them general population. Decisions regarding timing, place, mode delivery taken multidisciplinary including obstetricians, physicians, anesthetists, intensivists experienced care pregnancy. Ideally decisions take place consultation centers that have experience expertise all specialties.

Language: Английский

Citations

44
COVID-19 and Pregnancy DOI Open Access
Sonja A. Rasmussen, Denise J. Jamieson

Infectious Disease Clinics of North America, Journal Year: 2022, Volume and Issue: 36(2), P. 423 - 433

Published: Jan. 31, 2022

Language: Английский

Citations

43
Pregnancy outcomes after SARS-CoV-2 infection by trimester: A large, population-based cohort study DOI Creative Commons

Noga Fallach,

Yaakov Segal,

Jeny Agassy

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(7), P. e0270893 - e0270893

Published: July 20, 2022

Data regarding women infected with SARS-CoV-2 during early trimesters are scarce. We aimed to assess preterm birth (PTB) and small-for-gestational-age (SGA) rates in a large unselected cohort by trimester at infection overall.A retrospective study including all positive RT-PCR test non-ectopic singleton pregnancy between February 21st 2020 July 2nd 2021 (N = 2753). Each woman was matched non-infected pregnant age, last menstruation date, sector, socioeconomic status.Logistic regression conducted the risks of PTB SGA an interaction group infection. Multivariable models included underlying diseases, previous abortions null parity. Subgroup analyses were on symptomatic women.A total 2753 /2789 (98.7%) eligible that could be matched, among them, 17.4% 48.4% first third trimesters, respectively. While second infections not associated (p>0.8), particular after 34 weeks gestation had greater risk adjusted ORs 2.76 (95% CI 1.63-4.67) 7.10 2.44-20.61), further heightened (OR 4.28, 95% 1.94-9.25). comparable groups across Pregnancy loss incidence similar both (adjusted OR 1.16; 0.90-1.50).SARS-CoV-2 increased only late pregnancy, particularly women.

Language: Английский

Citations

40