Unraveling the Enigma of Cardiac Damage Caused by Lead: Understanding the Intricate Relationship between Oxidative Stress and Other Multifactorial Mechanisms

Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 153984 - 153984

Published: Oct. 1, 2024

Language: Английский

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Cardiovascular health in perspective: a comprehensive five-year geodatabase of hospitalizations and environmental factors in Mashhad, Iran

BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

This data note presents a comprehensive geodatabase of cardiovascular disease (CVD) hospitalizations in Mashhad, Iran, alongside key environmental factors such as air pollutants, built environment indicators, green spaces, and urban density. Using spatiotemporal dataset over 52,000 hospitalized CVD patients collected five years, the study supports approaches like advanced modeling, artificial intelligence, machine learning to predict high-risk areas guide public health interventions. includes detailed epidemiologic geospatial information on from January 1, 2016, December 31, 2020. It contains 52,176 confirmed cases demographic age, gender, admission date, ICD-10 codes, occurrence death, length hospital stay. The median age was 64 with 54.44% male. A notable 9.41% died during hospitalization. In addition hospitalization case file its shape created by joining 1301 census tracts, this quality indicators (SO2, PM2.5, CO, etc.). also incorporates socio-economic variables (population density, illiteracy, unemployment rates), infrastructure, data, providing view Mashhad.

Language: Английский

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SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Metals serve as co-factors for a host of metalloenzymes involved in mitochondrial metabolic reprogramming. Modifications metal homeostasis are linked to epigenetic mechanisms. However, the mechanisms through which affects cardiac fibrosis (CF) remain poorly understood. The content mouse heart samples was measured using inductively coupled plasma mass spectrometry. Cardiac fibroblast-specific MeCP2-deficient mice and control were treated with isoprenaline/angiotensin II induce CF. AAV9 carrying POSTN promoter-driven small hairpin RNA targeting MeCP2, YTHDF1, or SLC31A1 copper-chelating agent tetrathiomolybdate administered investigate their vital roles Histological biochemical analyses performed determine how YTHDF1/MeCP2 regulated expression reconstitution YTHDF1/MeCP2-deficient fibroblasts hearts study its effect on copper depletion fibrosis. Human tissues from atrial fibrillation patients used validate findings. Lower concentrations accompanied by down-regulation Fibroblast-specific deficiency enhances depletion, augments glycolysis, promotes fibroblast proliferation triggers inhibition due increased MeCP2-recognized methylating CpG islands promoter region restrains transcription. Conversely, MeCP2 knockdown rescued expression, resulting contradictory effects. up-regulation is associated elevated m6A mRNA levels. Mechanistically, YTHDF1 recognizes target induces translation. In human patients, reduced along levels observed. These changes enhanced A novel mechanism demonstrated increases impairs Findings provide new insights development preventive measures

Language: Английский

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Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1416 - 1416

Published: Jan. 26, 2022

The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial remains a serious global clinical issue, with ongoing need for novel approaches. Numerous experimental studies suggest that oxidative stress inflammation are deleterious to cardiovascular health, can increase heart susceptibility arrhythmias. It is quite interesting, however, various cardio-protective compounds antiarrhythmic properties potent anti-oxidative anti-inflammatory agents. These most likely target the pro-arrhythmia primary mechanisms. This review literature-based analysis presents realistic view efficacy molecular mechanisms current pharmaceuticals in use. include sodium-glucose cotransporter-2 inhibitors used diabetes treatment, statins dyslipidemia naturally protective omega-3 fatty acids. approach supports hypothesis or attenuation inflammatory abolish pro-arrhythmic factors development an arrhythmia substrate. could prove powerful tool reducing burden.

Language: Английский

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Neighborhood Environmental Burden and Cardiovascular Health in the US

JAMA Cardiology, Journal Year: 2023, Volume and Issue: 9(2), P. 153 - 153

Published: Nov. 13, 2023

Cardiovascular disease is the leading cause of death in US. However, little known about association between cumulative environmental burden and cardiovascular health across US neighborhoods.

Language: Английский

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