Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution DOI Creative Commons
Aleksandra Korolenko, Michael K. Skinner

Epigenetics, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 5, 2024

The epigenome and epigenetic inheritance were not included in the original modern synthesis theory or more recent extended evolutionary of evolution. In a broad range species, environment has been shown to play significant role natural selection, which recently occur through alterations inheritance. However, even with this evidence, field epigenetics left out synthesis, as well other current models. Epigenetic mechanisms can direct regulation genetic processes (e.g. gene expression) also be directly changed by environment. contrast, DNA sequence cannot altered goal review is present evidence how alter phenotypic variation numerous species. This at significantly higher frequency than change, so correlates change. addition, concept importance generational stability transgenerational incorporated into theory. For there better understanding biology, we must incorporate all aspects molecular genetics epigenetics) biological sciences adaptation).

Language: Английский

Maternal effects in the model system Daphnia: the ecological past meets the epigenetic future DOI Creative Commons
Trenton C. Agrelius, Jeffry L. Dudycha

Heredity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Maternal effects have been shown to play influential roles in many evolutionary and ecological processes. However, understanding how environmental stimuli induce within-generation responses that transverse across generations remains elusive, particularly when attempting segregate confounding from offspring genotypes. This review synthesizes literature regarding resource- predation-driven maternal the model system Daphnia , detailing generation responds seen generation(s). Our goal is demonstrate value of as a by showing general principles emerge studies on this system. By integrating results different types biotic drivers effects, we identified broadly applicable shared characteristics: 1. Many, but not all, involve size, influencing resistance starvation, infection, predation, toxins. 2. manifest more strongly offspring’s environment poor. 3. Strong are typically associated with strong across-generation responses. 4. The timing stress matters can raise or lower magnitude effect phenotype. 5. Embryonic exposure could be mistaken for effects. We outline questions prioritize future research discuss possibilities integration ecologically relevant natural populations molecular mechanisms make them possible, specifically addressing genetic variation incorporating information epigenetics. These small crustaceans unravel why non-genetic gets passed generations.

Language: Английский

Citations

2
Impact of Endocrine Disruptors upon Non-Genetic Inheritance DOI Open Access
Debbie Montjean, Anne-Sophie Neyroud, Marina Yéfimova

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3350 - 3350

Published: March 20, 2022

Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene expression without modifying the DNA sequence. It is commonly accepted that transgenerational inheritance of parentally acquired traits conveyed by epigenetic alterations also known as "epimutations". methylation, acetylation, histone modification, RNA-mediated effects and extracellular vesicle are mechanisms have been described so far be responsible for these epimutations. They may lead diverse phenotypes in progeny when they occur germ cells an affected individual. While EDC-induced health dramatically increased over past decade, limited on sperm epigenetics described. However, there has a gain interest this issue recent years. The gametes (sperm oocyte) represent targets thus route environmentally induced changes several generations. This review aims at providing overview might implicated inheritance.

Language: Английский

Citations

39
A global synthesis of peer‐reviewed research on the effects of hatchery salmonids on wild salmonids DOI Creative Commons
John McMillan,

Brian P. Morrison,

Nick Chambers

et al.

Fisheries Management and Ecology, Journal Year: 2023, Volume and Issue: 30(5), P. 446 - 463

Published: July 12, 2023

Abstract Hatcheries have long produced salmonids for fisheries and mitigation, though their widespread use is increasingly controversial because of potential impacts to wild salmonids. We conducted a global literature search peer‐reviewed publications (1970–2021) evaluating how hatchery affected salmonids, developed publicly available database, synthesized results. Two hundred six met our criteria, with 83% reporting adverse/minimally adverse effects on Adverse genetic diversity were most common, followed by productivity abundance via ecological processes. Few (3%) reported beneficial nearly all from intensive recovery programs used bolster highly depleted populations. Our review suggests hatcheries commonly in freshwater marine environments. Future research less studied effects—such as epigenetics—could improve knowledge management the full extent impacts.

Language: Английский

Citations

35
Stable Transmission of DNA Methylation Epimutations from Germlines to the Liver and Their Association with Fatty Liver Disease in Medaka DOI Creative Commons
Sourav Chakraborty, Santosh Anand, Xuegeng Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Background Environmental stressors can induce heritable traits in organisms across phyla, with distinct epigenetic alterations gametes and phenotypic outcomes several generations. However, the mechanisms underlying such intergenerational inheritance, mainly from germline to soma, are enigmatic, given that postfertilization embryos cells reprogram epigenome each generation gain their cellular identity. Here, we report stable transmission of differential DNA methylation (epimutations) associations nonalcoholic fatty liver disease (NAFLD) medaka exposed a model estrogenic chemical but ubiquitous environmental contaminant, bisphenol A (BPA). Results Ancestral BPA exposure F0 led advanced NAFLD unexposed grandchildren (F2) medaka. The F2 transcriptome histopathology revealed severe phenotype females. Whole-genome bisulfite sequencing sperm gradual shift promoter (hypomethylated) F1 (mix hypo- hypermethylated) (predominantly hypermethylated). Many differentially methylated promoters (DMPs) overlapped sperm, liver, regardless sex. In females, 1511 DMPs was found three generations, which associated protein-coding genes, miRNAs, others linked steatohepatitis (NASH). Among them, 27 canonical genes maintained consistently hypermethylated significant downregulation expression enrichment NAFLD-related pathways, fat digestion, glycerolipid metabolism, steroid biosynthesis. Conclusions present results demonstrate inter- transgenerational germline-to-germline germline-to-soma environmentally induced epimutations gametic epimutations, predicting phenotype-a clear passage

Language: Английский

Citations

1
Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees DOI Creative Commons
Connie J. Mulligan, Edward B. Quinn,

Dima Hamadmad

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 27, 2025

Maternal trauma influences infant and adult health outcomes may impact future generations through epigenetic modifications such as DNA methylation (DNAm). Research in humans on the intergenerational transmission of effects is limited. In this study, we assessed DNAm signatures war-related violence by comparing germline, prenatal, direct exposures to across three Syrian refugees. We compared families which a pregnant grandmother versus mother was exposed included control group with no exposure war. collected buccal swab samples survey data from mothers 1-2 children each 48 (n = 131 participants). Based an epigenome-wide association study (EWAS), identified differentially methylated regions (DMPs): 14 were associated germline 21 violence. Most DMPs showed same directionality change exposures, suggesting common response Additionally, age acceleration prenatal children, highlighting critical period utero development. This first report signature violence, has important implications for understanding inheritance trauma.

Language: Английский

Citations

1
The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review DOI Open Access
Marta Puzzono, Alessandro Mannucci, Simone Grannò

et al.

Cancers, Journal Year: 2021, Volume and Issue: 13(23), P. 5933 - 5933

Published: Nov. 25, 2021

The incidence of early-onset colorectal cancer, defined as cancer occurring in young adults under the age 50, is increasing globally. Knowledge etiological factors far from complete. Questionable eoCRCs’ exogenous are represented by processed meat, sugary drinks, alcohol, Western dietary pattern, overweight and obesity, physical inactivity, smoking, though with heterogeneous results. Therefore, we performed a systematic review to summarize current evidence on role diet lifestyle eoCRC risk factors. We systematically searched PubMed, Scopus, EMBASE up July 2021, for original studies evaluating diet, activity, BMI, smoking included twenty-six studies. Indeed, could represent modifiable key factors, whose recognition establish areas future interventions through public health strategies primary prevention. Additionally, discussed additional non-modifiable epigenetic regulation microbiota mediators triggered lifestyle.

Language: Английский

Citations

47
Transgenerational sperm DMRs escape DNA methylation erasure during embryonic development and epigenetic inheritance DOI Creative Commons
Millissia Ben Maamar, Yue Wang, Eric Nilsson

et al.

Current Zoology, Journal Year: 2023, Volume and Issue: 9(1)

Published: Jan. 1, 2023

Abstract Germline transmission of epigenetic information is a critical component inheritance. Previous studies have suggested that an erasure DNA methylation required to develop stem cells in the morula embryo. An exception involves imprinted genes escape this erasure. Transgenerational differential regions (DMRs) been speculated be imprinted-like and The current study was designed assess if embryos dichlorodiphenyltrichloroethane–induced transgenerational sperm DMR methylation. Observations demonstrate majority (98%) sites retain are not erased, so appearing similar sites. Interestingly, observations also low-density CpG genomic had significant increase embryo compared sperm. This contrast previously observed higher-density general during embryogenesis appears applicable high-density (e.g. islands) but neither nor deserts, which constitute vast genome’s role epigenetics more dynamic than simple

Language: Английский

Citations

18
Epigenetic biomarkers for disease susceptibility and preventative medicine DOI Creative Commons
Michael K. Skinner

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 263 - 277

Published: Jan. 3, 2024

Language: Английский

Citations

8
Canada’s Colonial Genocide of Indigenous Peoples: A Review of the Psychosocial and Neurobiological Processes Linking Trauma and Intergenerational Outcomes DOI Open Access
Kimberly Matheson,

Ann Seymour,

Jyllenna Landry

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(11), P. 6455 - 6455

Published: May 26, 2022

The policies and actions that were enacted to colonize Indigenous Peoples in Canada have been described as constituting cultural genocide. When one considers the long-term consequences from perspective of social environmental determinants health framework, impacts such on physical mental go well beyond loss. This paper addresses key historical current Canadian federal relation well-being Peoples. Far a mere lesson history, connections between colonialist present-day outcomes are evaluated terms transgenerational intergenerational transmission processes, including psychosocial, developmental, environmental, neurobiological mechanisms trauma responses. In addition, while created adverse living conditions for Peoples, resilience perseverance many aspects culture may be maintained through processes.

Language: Английский

Citations

28
Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion DOI Creative Commons
Zhen Qin, Aurélie Bouteau, Christopher Herbst

et al.

PLoS Pathogens, Journal Year: 2022, Volume and Issue: 18(9), P. e1010830 - e1010830

Published: Sept. 2, 2022

Hundreds of millions SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding the immune effects this platform. The mRNA-LNP-based is highly inflammatory, and its synthetic ionizable lipid component responsible for induction inflammation has long in vivo half-life. Since chronic can lead exhaustion non-responsiveness, sought determine pre-exposure on adaptive responses innate fitness. We found that mRNA-LNPs or LNP alone led long-term inhibition response, which could be overcome using standard adjuvants. On other hand, report after mRNA-LNPs, resistance mice heterologous infections with influenza virus increased while Candida albicans decreased. diminished correlated general decrease blood neutrophil percentages. Interestingly, pre-exposed platform pass down acquired traits their offspring, providing better protection against influenza. In summary, induces unexpected immunological changes affecting both infections. Thus, our studies highlight need more research platform’s true impact human health.

Language: Английский

Citations

27