Metabolic-associated fatty liver disease and pregnancy complications: new challenges and clinical perspectives DOI Creative Commons
Yang Zhang, Yifan Bu, Rui Zhao

et al.

Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

The term metabolic-associated fatty liver disease (MAFLD), with a global prevalence estimated at 38.77%, has gradually replaced the traditional concept of non-alcoholic (NAFLD). Compared to general population, incidence MAFLD is notably higher among pregnant women, posing potential risks both maternal and neonatal health. This review summarizes latest research on MAFLD, focusing its association pregnancy complications. Additionally, it provides comparative analysis previous studies NAFLD, presenting comprehensive perspective for clinical management. Findings suggest that women face risk gestational hypertension cesarean delivery compared those while diabetes mellitus remains similar between two conditions. associated an increased likelihood delivering large-for-gestational-age infants heightened preterm birth low weight. Current treatment strategies focus lifestyle modifications, such as dietary adjustments physical activity. However, there urgent need development safe effective pharmacological treatments, particularly tailored toward women. Future should delve deeper into causal relationships complications explore optimal therapeutic approaches improve outcomes mothers their infants.

Language: Английский

Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy DOI Creative Commons
Анна Старшинова, Leonid P. Churilov,

I. V. Kudryavtsev

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 5, 2025

The combination of tuberculosis and pregnancy always raises questions about therapy, the specialness management pregnancy, obstetrics, postpartum period, lactation; effect therapy on fetal development peculiarities course. Until recently, were considered a rare combination, but with growing problem HIV infection worsening screening among adults, this has become quite common. Moreover, cases congenital in newborns have begun to emerge. In review, we analyzed features immunologic immuno-neuroendocrine reactivity pregnant women that influence for prevalence TB TB/HIV coinfection. changes characteristic multifactorial antituberculosis immunity determine specificity course against background pregnancy. These contribute more severe than before structure clinical forms who became ill during first year after childbirth is characterized by greater severity, higher frequency multi-organ lesions, percentage bacterial isolates significantly developed period compared it poses particular threat, exacerbating immune response disorders affect effectiveness treatment disease progression general.

Language: Английский

Citations

0
The importance of gut microbiome in the perinatal period DOI Creative Commons

Giulia Catassi,

Sandra G. García,

Annamaria Sara Occhionero

et al.

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Language: Английский

Citations

3
Gestational Interrelationships among Gut-Metabolism-Transcriptome in Regulating Early Embryo Implantation and Placental Development in Mice DOI Open Access
Maozhang He, Shuai Lin,

Yuqi Liang

et al.

Published: Aug. 22, 2024

Decidualization of the uterine endometrium is a critical process for embryo implantation in mammals, primarily occurring on gestational day 8 pregnant mice. However, interplay between maternal gut microbiome, metabolism, and uterus at this specific time point remains poorly understood. This study employed multi-omics approach to investigate metabolic, transcriptomic changes associated with early pregnancy (gestational (E8)) Serum metabolomics revealed distinct metabolic profile E8 compared controls, differential metabolites enriched amino acid metabolism pathways. Gut microbial composition showed that mice exhibited higher alpha-diversity significant shift beta-diversity. Specifically, group displayed decrease pathogenic Proteobacteria an increase beneficial Bacteroidetes S24-7 taxa. Transcriptomics identified myriads gene control The differentially expressed genes were pathways involved Alanine, Aspartate Glutamate PI3K-Akt signaling, PPAR signaling pathway. Integrative analysis data uncovered potential mechanistic relationships among metabolites, microbiota, expression changes. Notably, Asns strong correlations metabolite L-Aspartatic acid, suggesting its role mediating crosstalk environment development during pregnancy. These findings provide valuable insights into complex metabolome, transcriptome context pregnancy, which may contribute our understanding underlying mechanisms development.

Language: Английский

Citations

0
Gestational Interrelationships among Gut–Metabolism–Transcriptome in Regulating Early Embryo Implantation and Placental Development in Mice DOI Creative Commons
Shuai Lin,

Yuqi Liang,

Jingqi Geng

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1902 - 1902

Published: Sept. 17, 2024

Decidualization of the uterine endometrium is a critical process for embryo implantation in mammals, primarily occurring on gestational day 8 pregnant mice. However, interplay between maternal gut microbiome, metabolism, and uterus at this specific time point remains poorly understood. This study employed multi-omics approach to investigate metabolic, transcriptomic changes associated with early pregnancy (gestational (E8)) Serum metabolomics revealed distinct metabolic profile E8 compared controls, differential metabolites enriched amino acid metabolism pathways. The microbial composition showed that mice exhibited higher alpha-diversity significant shift beta-diversity. Specifically, group displayed decrease pathogenic Proteobacteria an increase beneficial Bacteroidetes S24-7 taxa. Transcriptomics identified myriads genes control differentially expressed were pathways involved alanine, aspartate, glutamate PI3K-Akt signaling, PPAR signaling pathway. Integrative analysis data uncovered potential mechanistic relationships among metabolites, microbiota, gene expression changes. Notably,

Language: Английский

Citations

0
Metabolic-associated fatty liver disease and pregnancy complications: new challenges and clinical perspectives DOI Creative Commons
Yang Zhang, Yifan Bu, Rui Zhao

et al.

Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

The term metabolic-associated fatty liver disease (MAFLD), with a global prevalence estimated at 38.77%, has gradually replaced the traditional concept of non-alcoholic (NAFLD). Compared to general population, incidence MAFLD is notably higher among pregnant women, posing potential risks both maternal and neonatal health. This review summarizes latest research on MAFLD, focusing its association pregnancy complications. Additionally, it provides comparative analysis previous studies NAFLD, presenting comprehensive perspective for clinical management. Findings suggest that women face risk gestational hypertension cesarean delivery compared those while diabetes mellitus remains similar between two conditions. associated an increased likelihood delivering large-for-gestational-age infants heightened preterm birth low weight. Current treatment strategies focus lifestyle modifications, such as dietary adjustments physical activity. However, there urgent need development safe effective pharmacological treatments, particularly tailored toward women. Future should delve deeper into causal relationships complications explore optimal therapeutic approaches improve outcomes mothers their infants.

Language: Английский

Citations

0